To analyze HIV-1 genotypes in Lithuania and the transmission of drug-resistant viruses, HIV-1 sequences were obtained from 138 individuals, who were diagnosed as HIV-1 infected in 1990–2008 and represented all major risk groups. Subtype A strains, dominating in the former Soviet Union (90% of cases), were found in 60% of individuals, followed by subtype B (22%) and CRF03_AB (12%) strains. The remaining 7% of the strains included variants belonging to subtype C, CRF01_AE, CRF02_AG, more complex recombinant forms, and strains that could not be reliably genotyped. Analysis of virus genotypes per risk group revealed the circulation of distinct HIV-1 strains in different risk groups: subtype A viruses were present in 82% of injecting drug users (IDUs), but less than a half of heterosexually infected individuals and cases with unknown transmission route, and none of men having sex with men (MSM). We observed no mutations causing drug resistance among 27 newly diagnosed HIV-1 cases.
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References
1.
NabatovAA, KravchenkoON, LyulchukMG, ShcherbinskayaAM, LukashovVV. Simultaneous introduction of HIV type 1 subtype A and B viruses into injecting drug users in southern Ukraine at the beginning of the epidemic in the former Soviet Union. AIDS Res Hum Retroviruses, 2002; 18,12:891–895.
2.
NabatovAA, MasharskyAE, VerevochkinSVet al.The rate of epidemiological and virological changes during the transition from nascent to concentrated HIV epidemic stage in the former Soviet Union countries. AIDS Res Hum Retroviruses, 2007; 23,2:183–192.
3.
SaadMD, AlievQ, BotrosBAet al.Genetic forms of HIV Type 1 in the former Soviet Union dominate the epidemic in Azerbaijan. AIDS Res Hum Retroviruses, 2006; 22,8:796–800.
4.
LazouskayaNV, EreminVF, AdemaKWet al.The HIV type 1 epidemic in Belarus: Predominance of Eastern European subtype A strains and circulation of subtype B viruses. AIDS Res Hum Retroviruses, 2005; 21,9:830–833.
5.
LukashovVV, KaramovEV, EreminVF, TitovLP, GoudsmitJ. Extreme founder effect in an HIV type 1 subtype A epidemic among drug users in Svetlogorsk, Belarus. AIDS Res Hum Retroviruses, 1998; 14,12:1299–1303.
6.
ZarandiaM, TsertsvadzeT, CarrJKet al.HIV-1 genetic diversity and genotypic drug susceptibility in the Republic of Georgia. AIDS Res Hum Retroviruses, 2006; 22,5:470–476.
7.
EyzaguirreLM, ErasilovaIB, NadaiYet al.Genetic characterization of HIV-1 strains circulating in Kazakhstan. J Acquir Immune Defic Syndr, 2007; 46,1:19–23.
8.
BobkovAF, KazennovaEV, SukhanovaALet al.An HIV type 1 subtype A outbreak among injecting drug users in Kazakhstan. AIDS Res Hum Retroviruses, 2004; 20,10:1134–1136.
9.
BalodeD, FerdatsA, DievbernaIet al.Rapid epidemic spread of HIV type 1 subtype A1 among intravenous drug users in Latvia and slower spread of subtype B among other risk groups. AIDS Res Hum Retroviruses, 2004; 20,2:245–249.
10.
FerdatsA, KonichevaV, DievbernaI, LiljaE, AlbertJ. An HIV type 1 subtype A outbreak among injecting drug users in Latvia. AIDS Res Hum Retroviruses, 1999; 15,16:1487–1490.
11.
PandreaI, DescampsD, CollinGet al.HIV type 1 genetic diversity and genotypic drug susceptibility in the Republic of Moldova. AIDS Res Hum Retroviruses, 2001; 17,13:1297–1304.
12.
RumyantsevaOA, OlkhovskiyIA, MalyshevaMAet al.Epidemiological networks and drug resistance of HIV type 1 in Krasnoyarsk region, Russia. AIDS Res Hum Retroviruses, 2009; 25,9:931–936.
13.
BeyrerC, PatelZ, StachowiakJAet al.Characterization of the emerging HIV type 1 and HCV epidemics among injecting drug users in Dushanbe, Tajikistan. AIDS Res Hum Retroviruses, 2009; 25,9:853–860.
14.
NovitskyVA, MontanoMA, EssexM. Molecular epidemiology of an HIV-1 subtype A subcluster among injection drug users in the Southern Ukraine. AIDS Res Hum Retroviruses, 1998; 14,12:1079–1085.
15.
SaadMD, ShcherbinskayaAM, NadaiYet al.Molecular epidemiology of HIV Type 1 in Ukraine: Birthplace of an epidemic. AIDS Res Hum Retroviruses, 2006; 22,8:709–714.
16.
KurbanovF, KondoM, TanakaYet al.Human immunodeficiency virus in Uzbekistan: Epidemiological and genetic analyses. AIDS Res Hum Retroviruses, 2003; 19,9:731–738.
17.
CarrJK, NadaiY, EyzaguirreLet al.Outbreak of a West African recombinant of HIV-1 in Tashkent, Uzbekistan. J Acquir Immune Defic Syndr, 2005; 39,5:570–575.
18.
AdojaanM, KivisildT, MannikAet al.Predominance of a rare type of HIV-1 in Estonia. J Acquir Immune Defic Syndr, 2005; 39,5:598–605.
19.
ZetterbergV, UstinaV, LiitsolaKet al.Two viral strains and a possible novel recombinant are responsible for the explosive injecting drug use-associated HIV type 1 epidemic in Estonia. AIDS Res Hum Retroviruses, 2004; 20,11:1148–1156.
20.
LiitsolaK, HolmK, BobkovAet al.An AB recombinant and its parental HIV type 1 strains in the area of the former Soviet Union: Low requirements for sequence identity in recombination. AIDS Res Hum Retroviruses, 2000; 16,11:1047–1053.
21.
LukashovVV, HuismansR, RakhmanovaAGet al.Circulation of subtype A and gagA/envB recombinant HIV type 1 strains among injecting drug users in St. Petersburg, Russia, correlates with geographical origin of infections. AIDS Res Hum Retroviruses, 1999; 15,17:1577–1583.
22.
CaplinskasS. Epidemiology of HIV/AIDS in Lithuania in 1988–2001: Review of present situation and prognosis of HIV transmission trends. Medicina (Kaunas), 2004; 40,2:161–168.
23.
LukashovVV, CornelissenMTE, GoudsmitJet al.Simultaneous introduction of distinct HIV-1 subtypes into different risk groups in Russia, Byelorussia and Lithuania. AIDS, 1995; 9,5:435–439.
24.
LukashovVV, KuikenCL, VlahovD, CoutinhoRA, GoudsmitJ. Evidence for HIV type 1 strains of U.S. intravenous drug users as founders of AIDS epidemic among intravenous drug users in Northern Europe. AIDS Res Hum Retroviruses, 1996; 12,12:1179–1183.
25.
Op de CoulEL, PrinsM, CornelissenMet al.Using phylogenetic analysis to trace HIV-1 migration among western European injecting drug users seroconverting from 1984 to 1997. AIDS, 2001; 15,2:257–266.
