A molecular epidemiological investigation (n = 62) conducted in western Hubei, Central China, revealed that HIV-1 subtype B' (Thailand variant of subtype B) predominated not only among former plasma donors (FPDs) (29/29, 100%) but also among heterosexuals (27/31, 87%), suggesting that subtype B' appears to bridge the spread from FPDs in the general population in this particular area in Central China.
Get full access to this article
View all access options for this article.
References
1.
ShaoY, ZhengX, TianCet al.HIV/AIDS: Perspective on China. AIDS Patient Care STDS, 2001; 15:431–432.
2.
Ministry of Science and Technology C: Research progress. Nationwide HIV molecular epidemiology survey and its database setting, May30, 2004. Ministry of Science and Technology: China, 2004, 2006.
3.
OuCY, TakebeY, WenigerBGet al.Independent introduction of two major HIV-1 genotypes into distinct high-risk populations in Thailand. Lancet, 1993; 341:1171–1174.
4.
SuL, GrafM, ZhangYet al.Characterization of a virtually full-length human immunodeficiency virus type 1 genome of a prevalent intersubtype (C/B′) recombinant strain in China. J Virol, 2000; 74:11367–11376.
5.
PiyasirisilpS, McCutchanFE, CarrJKet al.A recent outbreak of human immunodeficiency virus type 1 infection in southern China was initiated by two highly homogeneous, geographically separated strains, circulating recombinant form AE and a novel BC recombinant. J Virol, 2000; 74:11286–11295.
6.
ZhangY, LuL, BaLet al.Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Med, 2006; 3:e443.
7.
Hai-LongH, JianZ, Ping-PingYet al.Genetic characterization of CRF01_AE full-length human immunodeficiency virus type 1 sequences from Fujian, China. AIDS Res Hum Retroviruses, 2007; 23:569–574.
8.
GuoD, DingN, XuYet al.Near full-length genome characterization of an HIV-1 CRF01_AE strain in Jiangsu, China: Evidence of two independent introductions from Fujian. AIDS Res Hum Retroviruses, 2009; 25:619–623.
9.
WangW, JiangS, LiSet al.Identification of subtype B, multiple circulating recombinant forms and unique recombinants of HIV type 1 in an MSM cohort in China. AIDS Res Hum Retroviruses, 2008; 24:1245–1254.
10.
YangR, XiaX, KusagawaS, ZhangC, BenK, TakebeY. On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China. AIDS, 2002; 16:1401–1407.
11.
WuZ, RouK, DetelsR. Prevalence of HIV infection among former commercial plasma donors in rural eastern China. Health Policy Plan, 2001; 16:41–46.
12.
ZhangL, ChenZ, CaoYet al.Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in China. J Virol, 2004; 78:13591–13599.
13.
DengX, LiuH, ShaoY, RaynerS, YangR. The epidemic origin and molecular properties of B': A founder strain of the HIV-1 transmission in Asia. AIDS, 2008; 22:1851–1858.
14.
MastroTD, YipR. The legacy of unhygienic plasma collection in China. AIDS, 2006; 20:1451–1452.
15.
LiuP, XiangK, TangHet al.Molecular epidemiology of human immunodeficiency virus type 1 and hepatitis C virus in former blood donors in central China. AIDS Res Hum Retroviruses, 2008; 24:1–6.
16.
ThompsonJD, GibsonTJ, PlewniakF, JeanmouginF, HigginsDG. The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res, 1997; 25:4876–4882.
17.
SaitouN, NeiM. The neighbor-joining method: A new method for reconstructing phylogenetic trees. Mol Biol Evol, 1987; 4:406–425.
18.
KimuraM. A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol, 1980; 16:111–120.
LoleKS, BollingerRC, ParanjapeRSet al.Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol, 1999; 73:152–160.
21.
LiN, WangZ, SunDet al.HIV among plasma donors and other high-risk groups in Henan, China. J Acquir Immune Defic Syndr, 2010; 53,Suppl 1:S41–47.