Restricted accessResearch articleFirst published online 2011-02
Short Communication: Quantitative Proteomic Plasma Profiling Reveals Activation of Host Defense to Oxidative Stress in Chronic SIV and Methamphetamine Comorbidity
The double epidemic of substance abuse and HIV infection is a multifaceted problem To investigate mechanistic clues to the effects of substance abuse on infected individuals we preformed quantitative proteomic profiling of plasma in a methamphetamine treated nonhuman primate model for AIDS. A nontargeted quantitative approach identified extracellular superoxide dismutase to be significantly upregulated by SIV and methamphetamine treatment, and targeted studies revealed an increase in expression in the antixoidant glutathione S-transferase, thus pointing to a compensatory response to increased oxidative stress in methamphetamine-treated animals.
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References
1.
DegenhardtL, MathersB, GuarinieriMet al.Methamphetamine use and associated HIV: Implications for global policy and public health. Int J Drug Policy, 2010; 21,5:347–358.
2.
CadetJL, KrasnovaIN. Interactions of HIV and methamphetamine: Cellular and molecular mechanisms of toxicity potentiation. Neurotox Res, 2007; 12,3:181–204.
3.
TheodoreS, StolbergS, CassWA, MaragosWF. Human immunodeficiency virus-1 protein tat and methamphetamine interactions. Ann NY Acad Sci, 2006; 1074:178–190.
4.
ShawLM, KoreckaM, ClarkCM, LeeVM, TrojanowskiJQ. Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics. Nat Rev Drug Discov, 2007; 6,4:295–303.
5.
BurdoTH, MarcondesMC, LaniganCM, PenedoMC, FoxHS. Susceptibility of Chinese rhesus monkeys to SIV infection. AIDS, 2005; 19,15:1704–1706.
6.
WatryD, LaneTE, StrebM, FoxHS. Transfer of neuropathogenic simian immunodeficiency virus with naturally infected microglia. Am J Pathol, 1995; 146,4:914–923.
7.
MaddenLJ, FlynnCT, ZandonattiMAet al.Modeling human methamphetamine exposure in nonhuman primates: Chronic dosing in the rhesus macaque leads to behavioral and physiological abnormalities. Neuropsychopharmacology, 2005; 30,2:350–359.
8.
ThompsonPM, HayashiKM, SimonSLet al.Structural abnormalities in the brains of human subjects who use methamphetamine. J Neurosci, 2004; 24,26:6028–6036.
9.
MarcondesMC, FlynnC, WatryDD, ZandonattiM, FoxHS. Methamphetamine increases brain viral load and activates NK cells in SIV-infected monkeys. Am J Pathol, 2010; 177:355–361.
10.
PendyalaG, TraugerSA, SiuzdakG, FoxHS. Quantitative plasma proteomic profiling identifies the vitamin E binding protein afamin as a potential pathogenic factor in SIV induced CNS disease. J Proteome Res, 2010; 9,1:352–358.
11.
Perez-CasanovaA, HusainK, NoelRJJr., Rivera-AmillV, KumarA. Interaction of SIV/SHIV infection and morphine on plasma oxidant/antioxidant balance in macaque. Mol Cell Biochem, 2008; 308,1–2:169–175.
12.
Perez-CasanovaA, NoelRJJr., Rivera-AmillV, HusainK, KumarA. Morphine-mediated deterioration of oxidative stress leads to rapid disease progression in SIV/SHIV-infected macaques. AIDS Res Hum Retroviruses, 2007; 23,8:1004–1007.
13.
GluckMR, MoyLY, JayatillekeE, HoganKA, ManzinoL, SonsallaPK. Parallel increases in lipid and protein oxidative markers in several mouse brain regions after methamphetamine treatment. J Neurochem, 2001; 79,1:152–160.
JayanthiS, LadenheimB, CadetJL. Methamphetamine-induced changes in antioxidant enzymes and lipid peroxidation in copper/zinc-superoxide dismutase transgenic mice. Ann NY Acad Sci, 1998; 844:92–102.
16.
AliSF, MartinJL, BlackMD, ItzhakY. Neuroprotective role of melatonin in methamphetamine- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity. Ann NY Acad Sci, 1999; 890:119.
17.
De VitoMJ, WagnerGC. Methamphetamine-induced neuronal damage: A possible role for free radicals. Neuropharmacology, 1989; 28,10:1145–1150.
18.
FukamiG, HashimotoK, KoikeK, OkamuraN, ShimizuE, IyoM. Effect of antioxidant N-acetyl-L-cysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine. Brain Res, 2004; 1016,1:90–95.
19.
ImamSZ, AliSF. Selenium, an antioxidant, attenuates methamphetamine-induced dopaminergic toxicity and peroxynitrite generation. Brain Res, 2000; 855,1:186–191.
20.
CadetJL, AliS, EpsteinC. Involvement of oxygen-based radicals in methamphetamine-induced neurotoxicity: Evidence from the use of CuZnSOD transgenic mice. Ann NY Acad Sci, 1994; 738:388–391.
21.
HirataH, LadenheimB, CarlsonE, EpsteinC, CadetJL. Autoradiographic evidence for methamphetamine-induced striatal dopaminergic loss in mouse brain: Attenuation in CuZn-superoxide dismutase transgenic mice. Brain Res, 1996; 714,1-2:95–103.
22.
LiW, Malpica-LlanosTM, GundryRet al.Nitrosative stress with HIV dementia causes decreased L-prostaglandin D synthase activity. Neurology, 2008; 70,19 Pt 2:1753–1762.
MatsushitaM, ThielS, JenseniusJC, TeraiI, FujitaT. Proteolytic activities of two types of mannose-binding lectin-associated serine protease. J Immunol, 2000; 165,5:2637–2642.
25.
ThielS, Vorup-JensenT, StoverCMet al.A second serine protease associated with mannan-binding lectin that activates complement. Nature, 1997; 386,6624:506–510.
26.
NelsonRAJr., JensenJ, GigliI, TamuraN. Methods for the separation, purification and measurement of nine components of hemolytic complement in guinea-pig serum. Immunochemistry, 1966; 3,2:111–135.
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