Complex Splicing of Simian Immunodeficiency Virus (mac 251-32H) rev Gene Transcript from Infected Macaques

Abstract

Sequences of the simian immunodeficiency virus (SIV) rev mRNA transcripts were characterized from peripheral blood lymphocytes (PBLs) of two macaques experimentally infected with SIVmac251 (32H reisolate). This analysis has demonstrated that the complex splicing patterns observed for the rev mRNA transcripts originally identified in vitro is not an artifact of tissue culture, but is also found in vivo.