Diagnostic Value of the Determination of an Interferon-induced Enzyme Activity: Decreased 2′,5′-oligoadenylate Dependent Binding Protein Activity in Aids Patient Lymphocytes

Abstract

The 2, 5′-oligoadenylate dependent binding protein activity was measured in peripheral blood lymphocyte extracts of AIDS and pre-AIDS and compared to healthy heterosexual controls. The binding activity in lymphocytes from AIDS (mean, 0.71 fmole/10⁶ cells) and pre-AIDS (mean, 0.66 fmole/10⁶ cells) was approximately 65% lower than that found in controls (mean, 2.41 fmole/10⁶ cells) suggesting that this enzymatic activity may be a useful biochemical marker for the diagnosis of AIDS