Drug Repurposing Patent Applications April–June 2023

Lam YC , Bowman AB , Jafar-Nejad P , et al. ATAXIN-1 interacts with the repressor capicua in its native complex to cause SCA1 neuropathology. Cell, 2006; 127(7):1335–1347; doi: 10.1016/j.cell.2006.11.038.

Chen J-M , Chen S-K , Jin P-P , et al. Identification of the ataxin-1 interaction network and its impact on spinocerebellar ataxia type 1. Hum Genomics, 2022; 16(1):29; doi: 10.1186/s40246-022-00404-0.

Zhang S , Williamson NA , Duvick L , et al. The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways. Nat Commun, 2020; 11(1):3343; doi: 10.1038/s41467-020-17145-0.

Perkins E , Suminaite D , Jackson M . Cerebellar ataxias: β-III spectrin's interactions suggest common pathogenic pathways. J Physiol, 2016; 594(16):4661–4676; doi: 10.1113/JP271195.

Hirota T , King BH . Autism spectrum disorder: A review. JAMA, 2023; 329(2):157–168; doi: 10.1001/jama.2022.23661.

Burnstock G . An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration. Neuropharmacology, 2016; 104:4–17; doi: 10.1016/j.neuropharm.2015.05.031.

Chen X , Wang Q , Yang J , et al. Diagnostic and therapeutic value of P2Y12R in epilepsy. Front Pharmacol, 2023; 14:1179028.

Hu X , Sang Y , Yang M , et al. Prevalence of chronic kidney disease-associated pruritus among adult dialysis patients: A meta-analysis of cross-sectional studies. Medicine, 2018; 97(21):e10633; doi: 10.1097/MD.0000000000010633.

Garcovich S , Maurelli M , Gisondi P , et al. Pruritus as a distinctive feature of type 2 inflammation. Vaccines, 2021; 9(3):303; doi: 10.3390/vaccines9030303.

Río JPD , Molina S , Hidalgo-Lanussa O , et al. Tibolone as hormonal therapy and neuroprotective agent. Trends Endocrinol Metab, 2020; 31(10):742–759; doi: 10.1016/j.tem.2020.04.007.

Dhillon RJ , Hasni S . Pathogenesis and management of sarcopenia. Clin Geriatr Med, 2017; 33(1):17–26; doi: 10.1016/j.cger.2016.08.002.

Cipriani A , Furukawa TA , Salanti G , et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. Lancet, 2018; 391(10128):1357–1366; doi: 10.1016/S0140-6736(17)32802-7.

Versiani M , Cassano G , Perugi G , et al. Reboxetine, a selective norepinephrine reuptake inhibitor, is an effective and well-tolerated treatment for panic disorder. J Clin Psychiatry, 2002; 63(1):16981.

Ghanizadeh A . A systematic review of reboxetine for treating patients with attention deficit hyperactivity disorder. Nord J Psychiatry, 2015; 69(4):241–248; doi: 10.3109/08039488.2014.972975.

Mahdy MAA . Skeletal muscle fibrosis: An overview. Cell Tissue Res, 2019; 375(3):575–588; doi: 10.1007/s00441-018-2955-2.

Molina T , Fabre P , Dumont NA . Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases. Open Biol, 2021; 11(12):210110; doi: 10.1098/rsob.210110.

Clozel M , Salloukh H . Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. Ann Med, 2005; 37(1):2–12; doi: 10.1080/07853890410018925.

Jenner P , Katzenschlager R . Apomorphine—pharmacological properties and clinical trials in Parkinson's disease. Parkinsonism Relat Disord, 2016; 33(Suppl. 1):S13–S21; doi: 10.1016/j.parkreldis.2016.12.003.

Guillén V , Rueda J-R , Lopez-Argumedo M , et al. Apomorphine for the treatment of erectile dysfunction: Systematic review and meta-analysis. Arch Sex Behav, 2020; 49(8):2963–2979; doi: 10.1007/s10508-020-01817-5.

Auffret M , Drapier S , Vérin M . New tricks for an old dog: A repurposing approach of apomorphine. Eur J Pharmacol, 2019; 843:66–79; doi: 10.1016/j.ejphar.2018.10.052.

Zhan C , Huang M , Yang X , et al. MLKL: Functions beyond serving as the executioner of necroptosis. Theranostics, 2021; 11(10):4759–4769; doi: 10.7150/thno.54072.

Makimoto G , Ohashi K , Maeda Y , et al. Anaplastic lymphoma kinase fusion: A review of therapeutic drugs and treatment strategies. Acta Med Okayama, 2020; 74(5):371–379.

Reshetnyak AV , Rossi P , Myasnikov AG , et al. Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature, 2021; 600(7887):153–157; doi: 10.1038/s41586-021-04140-8.

Agosti F , Altier C . pHluorin-tagged TRPV1 shines light on capsaicin tachyphylaxis. Channels (Austin), 2019; 13(1):308–310; doi: 10.1080/19336950.2019.1638695.

Defaye M , Iftinca MC , Gadotti VM , et al. The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain. J Clin Invest, 2022; 132(12):e154317; doi: 10.1172/JCI154317.

Shi Y , Abe C , Holloway BB , et al. Nalcn is a “leak” sodium channel that regulates excitability of brainstem chemosensory neurons and breathing. J Neurosci, 2016; 36(31):8174–8187; doi: 10.1523/JNEUROSCI.1096-16.2016.

Bouasse M , Impheng H , Servant Z , et al. Functional expression of CLIFAHDD and IHPRF pathogenic variants of the NALCN channel in neuronal cells reveals both gain- and loss-of-function properties. Sci Rep, 2019; 9(1):11791; doi: 10.1038/s41598-019-48071-x.

Woertler K . Tumors and tumor-like lesions of peripheral nerves. Semin Musculoskelet Radiol, 2010; 14(5):547–558; doi: 10.1055/s-0030-1268073.

Solares I , Viñal D , Morales-Conejo M , et al. Novel molecular targeted therapies for patients with neurofibromatosis type 1 with inoperable plexiform neurofibromas: A comprehensive review. ESMO Open, 2021; 6(4):100223; doi: 10.1016/j.esmoop.2021.100223.

Mitrović A , Kos J . Nitroxoline: Repurposing its antimicrobial to antitumor application. Acta Biochim Pol, 2019; 66(4):521–531; doi: 10.1838/8/abp.2019_2904.

Balakumar P , Nyo YH , Renushia R , et al. Classical and pleiotropic actions of dipyridamole: Not enough light to illuminate the dark tunnel?. Pharmacol Res, 2014; 87:144–150; doi: 10.1016/j.phrs.2014.05.008.

Asoh K , Saburi Y , Sato S , et al. Potentiation of some anticancer agents by dipyridamole against drug-sensitive and drug-resistant cancer cell lines. Jpn J Cancer Res, 1989; 80(5):475–481; doi: 10.1111/j.1349-7006.1989.tb02339.x.

Thomé MP , Pereira LC , Onzi GR , et al. Dipyridamole impairs autophagic flux and exerts antiproliferative activity on prostate cancer cells. Exp Cell Res, 2019; 382(1):111456; doi: 10.1016/j.yexcr.2019.06.001.

Goda AE , Erikson RL , Sakai T , et al. Preclinical evaluation of bortezomib/dipyridamole novel combination as a potential therapeutic modality for hematologic malignancies. Mol Oncol, 2015; 9(1):309–322; doi: 10.1016/j.molonc.2014.08.010.

Parker AM , Sricharoenchai T , Raparla S , et al. Posttraumatic stress disorder in critical illness survivors: A metaanalysis. Crit Care Med, 2015; 43(5):1121; doi: 10.1097/CCM.0000000000000882.

Dunlop BW , Wong A . The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions. Prog Neuropsychopharmacol Biol Psychiatry, 2019; 89:361–379; doi: 10.1016/j.pnpbp.2018.10.010.

Kulldorff M , Dashevsky I , Avery TR , et al. Drug safety data mining with a tree-based scan statistic. Pharmacoepidemiol Drug Saf, 2013; 22(5):517–523; doi: 10.1002/pds.3423.

Chen S , Harris M . NS5A domain I antagonises PKR to facilitate the assembly of infectious hepatitis C virus particles. PLoS Pathog, 2023; 19(2):e1010812; doi: 10.1371/journal.ppat.1010812.

Hwang K-D , Bak MS , Kim SJ , et al. Restoring synaptic plasticity and memory in mouse models of Alzheimer's disease by PKR inhibition. Mol Brain, 2017; 10(1):57; doi: 10.1186/s13041-017-0338-3.

Smith NB , Doran JM , Sippel LM , et al. Fear extinction and memory reconsolidation as critical components in behavioral treatment for posttraumatic stress disorder and potential augmentation of these processes. Neurosci Lett, 2017; 649:170–175; doi: 10.1016/j.neulet.2017.01.006.

Tam OH , Ostrow LW , Gale Hammell M . Diseases of the nERVous system: Retrotransposon activity in neurodegenerative disease. Mob DNA, 2019; 10(1):32; doi: 10.1186/s13100-019-0176-1.

Dai L , Huang Q , Boeke JD . Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochem, 2011; 12(1):18; doi: 10.1186/1471-2091-12-18.

Li M , Zhao J , Tang Q , et al. Lamivudine improves cognitive decline in SAMP8 mice: Integrating in vivo pharmacological evaluation and network pharmacology. J Cell Mol Med, 2021; 25(17):8490–8503; doi: 10.1111/jcmm.16811.

Martinez de Lagran M , Elizalde-Torrent A , Paredes R , et al. Lamivudine, a reverse transcriptase inhibitor, rescues cognitive deficits in a mouse model of down syndrome. J Cell Mol Med, 2022; 26(15):4210–4215; doi: 10.1111/jcmm.17411.

Bianco AC , da Conceição RR . The deiodinase trio and thyroid hormone signaling. In: Thyroid Hormone Nuclear Receptor: Methods and Protocols. Methods in Molecular Biology, vol 1801. ( Plateroti M , Samarut J . eds.) Humana Press: New York, NY, USA; 2018; pp. 67–83; doi: 10.1007/978-1-4939-7902-8_8.

Sabatino L , Vassalle C , Seppia CD , et al. Deiodinases and the three types of thyroid hormone deiodination reactions. Endocrinol Metab, 2021; 36(5):952–964; doi: 10.3803/EnM.2021.1198.

Zhang Y . I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 2008; 9(1):40; doi: 10.1186/1471-2105-9-40.

Anderton RS , Meloni BP , Mastaglia FL , et al. Spinal muscular atrophy and the antiapoptotic role of survival of motor neuron (SMN) protein. Mol Neurobiol, 2013; 47(2):821–832; doi: 10.1007/s12035-013-8399-5.

Tisdale S , Pellizzoni L . Disease mechanisms and therapeutic approaches in spinal muscular atrophy. J Neurosci, 2015; 35(23):8691–8700; doi: 10.1523/JNEUROSCI.0417-15.2015.

Markati T , Fisher G , Ramdas S , et al. Risdiplam: An investigational survival motor neuron 2 (SMN2) splicing modifier for spinal muscular atrophy (SMA). Expert Opin Investig Drugs, 2022; 31(5):451–461; doi: 10.1080/13543784.2022.2056836.