Reactive oxygen species (ROS) and reactive nitrogen species (RNS) can act as both intra- and intercellular messengers and be produced exogenously and endogenously. Enhanced production of ROS and RNS causes oxidative stress (OS) leading to damage in lipids, proteins, glucides, DNA, and RNA. Treatment strategies to reduce OS levels may reduce their side-effects. The traditional healing method of acupuncture has been widely used to treat many medical disorders.
Objective:
This article is an overview of the therapeutic effects of acupuncture on OS-induced major gene regulation and epigenetic modification.
Methods:
Databases searched included PubMed, ScienceDirect, and Google Scholar (publications in English and other languages with English abstracts) from 1966 to June 2015. Publications that were irrelevant, duplications, or that contained duplicated data were excluded.
Results:
Changes were reviewed in the expression levels and in the epigenetic status of genes reported in 55 published works in which acupuncture was used to treat OS-related conditions.
Conclusions:
Accumulating evidence demonstrates the reducing effects of acupuncture therapy on stress-induced biomarkers. These effects are mediated, at least partially, by modulating the expression and epigenetic status of specific genes. However, antioxidative effects, specifically epigenetic modifications caused by acupuncture, should be clarified more by further studies.
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