van BeekJHGM, KirkwoodTBL, BassingthwaighteJB. Understanding the physiology of the ageing individual: Computational modelling of changes in metabolism and endurance. Interface Focus, 2016; 6:20150079.
2.
WangQ, ZhanY, PedersenNL, et al.Telomere length and all-cause mortality: A meta-analysis. Ageing Res Rev, 2018; 48:11–20.
3.
CawthonRM, SmithKR, O'BrienE, et al.Association between telomere length in blood and mortality in people aged 60 years or older. Lancet (London, England), 2003; 361:393–395.
4.
NjajouOT, HsuehW-C, BlackburnEH, et al.Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol Ser A, 2009; 64A:860–864.
5.
García-CalzónS, GeaA, RazquinC, et al.Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: The PREDIMED-NAVARRA trial. Int J Obes, 2014; 38:177–182.
6.
BoccardiV, EspositoA, RizzoMR, et al.Mediterranean diet, telomere maintenance and health status among elderly. PLoS One, 2013; 8:e62781.
7.
XuQ, ParksCG, DeRooLA, et al.Multivitamin use and telomere length in women. Am J Clin Nutr, 2009; 89:1857–1863.
8.
Kiecolt-GlaserJK, EpelES, BeluryMA, et al.Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial. Brain Behav Immun, 2013; 28:16–24.
9.
SanftT, UsiskinI, HarriganM, et al.Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: The lifestyle, exercise, and nutrition (LEAN) study. Breast Cancer Res Treat, 2018; 172:105–112.
10.
Freitas-SimoesT-M, CofánM, BlascoM, et al.Walnut consumption for two years and leukocyte telomere attrition in mediterranean elders: Results of a randomized controlled trial. Nutrients, 2018; 10:1907.
11.
LiuP, ZhaoH, LuoY. Anti-aging implications of Astragalus membranaceus (Huangqi): A well-known Chinese tonic. Aging Dis, 2017; 8:868–886.
12.
WangN, LiuJ, XieF, et al.miR-124/ATF-6, a novel lifespan extension pathway of Astragalus polysaccharide in Caenorhabditis elegans. J Cell Biochem, 2015; 116:242–251.
13.
LiX-T, ZhangY-K, KuangH-X, et al.Mitochondrial protection and anti-aging activity of astragalus polysaccharides and their potential mechanism. Int J Mol Sci, 2012; 13:1747–1761.
14.
FauceSR, JamiesonBD, ChinAC, et al.Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J Immunol, 2008; 181:7400–7406.
15.
YungL, LamW, HoM, et al.Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types. Planta Med, 2012; 78:115–121.
16.
HarleyCB, LiuW, BlascoM, et al.A natural product telomerase activator as part of a health maintenance program. Rejuvenation Res, 2011; 14:45–56.
17.
SalvadorL, SingaraveluG, HarleyCB, et al.A natural product telomerase activator lengthens telomeres in humans: A randomized, double blind, and placebo controlled study. Rejuvenation Res, 2016; 19:478–484.
18.
LiZ, LinH, GuL, et al.Herba cistanche (Rou Cong-Rong): One of the best pharmaceutical gifts of Traditional Chinese Medicine. Front Pharmacol, 2016; 7:41.
19.
ZhangHQ, LiY, SongYY. Effect of polysaccharides of Cistanche deserticola on immune cells and telomerase activity in aging mice. J Chinese Pharm Sci, 2011; 46:1081–1083.
20.
ZhangHQ, WengXJ, ChenLL, LiX. Effect of Cistanche tubulosa (Scheuk) Wight acteoside on telomerase activity and immunity of aging mice. Chinese J Pharmacol Toxicol, 2008; 22:270–273.
21.
ZhangK, MaX, HeW, et al.Extracts of Cistanche deserticola can antagonize immunosenescence and extend life span in Senescence-Accelerated Mouse Prone 8 (SAM-P8) mice. Evid Based Complement Alternat Med, 2014; 2014:601383.
22.
GuoQ, ZhouY, WangC-J, et al.An open-label, nonplacebo-controlled study on Cistanche tubulosa glycoside capsules (Memoregain®) for treating moderate Alzheimer's disease. Am J Alzheimers Dis Other Dementiasr, 2013; 28:363–370.
23.
LeeJ-H, ChoiS-H, KwonO-S, et al.Effects of ginsenosides, active ingredients of Panax ginseng, on development, growth, and life span of Caenorhabditis elegans. Biol Pharm Bull, 2007; 30:2126–2134.
24.
ZhaoC, ChenX, ZhuY, et al.Roles of telomere and telomerase in the process of ginseno-side Rg1 protection against tert-butyl hydroperoxide-induced senescence in WI-38 cells. Chinese Pharmacol Bull, 2005; 21:61–66.
25.
ZhouY, JiangR, YangB, et al.Changes of telomere and telomerase in effect of ginsenoside Rg1 to delay hematopoietic stem cell senescence. Zhongguo Zhong Yao Za Zhi, 2011; 36:3172–3175.
26.
ChaoW-W, LinB-F. Bioactivities of major constituents isolated from Angelica sinensis (Danggui). Chin Med, 2011; 6:29.
27.
ZhangX-P, LiuJ, XuC-Y, et al.Effect of Angelica sinensis polysaccharide on expression of telomere, telomerase and P53 in mice aging hematopoietic stem cells. Zhongguo Zhong Yao Za Zhi, 2013; 38:2354–2358.
28.
AubreyBJ, KellyGL, JanicA, et al.How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?. Cell Death Differ, 2018; 25:104–113.
29.
XiaG, HanX, QiJ, et al.The effects of astragalus polysaccharide on zebrafish cell apoptosis and senescence. Am J Mol Biol, 2012; 02:103–109.
30.
SreenivasuluK, VijayalakshmiM, SambasivaraoKR. Regulation studies of telomerase gene in cancer cells by lentinan. Avicenna J Med Biotechnol, 2010; 2:181–185.
31.
YuenJWM, GohelMDI, AuDW-T. Telomerase-associated apoptotic events by mushroom Ganoderma lucidum on premalignant human urothelial cells. Nutr Cancer, 2007; 60:109–119.
32.
GonulO, AydinHH, KalmisE, et al.Effects of Ganoderma lucidum (higher basidiomycetes) extracts on the miRNA profile and telomerase activity of the MCF-7 breast cancer cell line. Int J Med Mushrooms, 2015; 17:231–239.
33.
LiH, MaF, HuM, et al.Polysaccharides from medicinal herbs as potential therapeutics for aging and age-related neurodegeneration. Rejuvenation Res, 2014; 17:201–204.
34.
LaplanteM, SabatiniDM. mTOR signaling at a glance. J Cell Sci, 2009; 122:3589–3594.
35.
GuillénC, BenitoM. mTORC1 overactivation as a key aging factor in the progression to type 2 diabetes mellitus. Front Endocrinol (Lausanne), 2018; 9:621.
36.
WeichhartT. mTOR as regulator of lifespan, aging, and cellular senescence: A mini-review. Gerontology, 2018; 64:127–134.
37.
ZhuangW, YueL, DangX, et al.Rosenroot (rhodiola): Potential applications in aging-related diseases. Aging Dis, 2019; 10:134–146.
38.
WangX, DuX, ZhouY, et al.Time-dependent effects of late-onset dietary intake of salidroside on lifespan and age-related biomarkers of the annual fish Nothobranchius guentheri. Oncotarget, 2018; 9:14882–14894.
39.
ArabitJGJ, ElhajR, SchrinerSE, et al.Rhodiola rosea improves lifespan, locomotion, and neurodegeneration in a Drosophila melanogaster model of Huntington's disease. Biomed Res Int, 2018; 2018:1–8.
40.
ZhengX-T, WuZ-H, WeiY, et al.Induction of autophagy by salidroside through the AMPK-mTOR pathway protects vascular endothelial cells from oxidative stress-induced apoptosis. Mol Cell Biochem, 2017; 425:125–138.
41.
ChenY-N, LiuH, ZhaoH-B, et al.Salidroside via ERK1/2 and PI3K/AKT/mTOR signal pathway induces mouse bone marrow mesenchymal stem cells differentiation into neural cells. Yao Xue Xue Bao, 2013; 48:1247–1252.
42.
ZhongX, LinR, LiZ, et al.Effects of Salidroside on cobalt chloride-induced hypoxia damage and mTOR signaling repression in PC12 cells. Biol Pharm Bull, 2014; 37:1199–1206.
43.
LiY, PhamV, BuiM, et al.Rhodiola rosea L.: An herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Curr Pharmacol Reports, 2017; 3:384–395.
44.
ZhangS, ZhangL, ZhangH, et al.Hongjingtian injection attenuates myocardial oxidative damage via promoting autophagy and inhibiting apoptosis. Oxid Med Cell Longev, 2017; 2017:6965739.
45.
ShenL-R, ParnellLD, OrdovasJM, et al.Curcumin and aging. Biofactors, 2013; 39:133–140.
46.
GuoS, LongM, LiX, et al.Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway. Mol Med Rep, 2016; 13:2187–2193.
47.
ZhangG, CaoJ, YangE, et al.Curcumin improves age-related and surgically induced osteoarthritis by promoting autophagy in mice. Biosci Rep, 2018; 38:BSR20171691.
48.
BeeversCS, ChenL, LiuL, et al.Curcumin disrupts the mammalian target of rapamycin-raptor complex. Cancer Res, 2009; 69:1000–1008.
49.
OshiroN, YoshinoK, HidayatS, et al.Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells, 2004; 9:359–366.
50.
KanaiM, YoshimuraK, AsadaM, et al.A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemother Pharmacol, 2011; 68:157–164.
51.
EpelbaumR, SchafferM, VizelB, et al.Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer, 2010; 62:1137–1141.
52.
Bayet-robertM, KwiatkowskiF, LeheurteurM, et al.Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther, 2010; 9:8–14.
53.
SamadianF, DaliliN, Poor-Reza GholiF, et al.Evaluation of curcumin's effect on inflammation in hemodialysis patients. Clin Nutr ESPEN, 2017; 22:19–23.
54.
PastorelliD, FabricioASC, GiovanisP, et al.Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial. Pharmacol Res, 2018; 132:72–79.
55.
AdibianM, HodaeiH, NikpayamO, et al.The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Phyther Res, 2019; 33:1374–1383.
56.
MaulinaT, DianaH, CahyantoA, et al.The efficacy of curcumin in managing acute inflammation pain on the post-surgical removal of impacted third molars patients: A randomised controlled trial. J Oral Rehabil, 2018; 45:677–683.
57.
WeiskirchenS, WeiskirchenR. Resveratrol: How much wine do you have to drink to stay healthy?. Adv Nutr, 2016; 7:706–718.
58.
TangZ-M, ZhaiX-X, DingJ-C. Expression of mTOR/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol intervention. Mol Med Rep, 2017; 15:2546.
59.
HongS, ZhaoB, LombardDB, et al.Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation. J Biol Chem, 2014; 289:13132–13141.
60.
GhoshHS, McBurneyM, RobbinsPD. SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One, 2010; 5:e9199.
61.
LiuM, WilkSA, WangA, et al.Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. J Biol Chem, 2010; 285:36387–36394.
62.
CatenaV, FanciulliM. Deptor: Not only a mTOR inhibitor. J Exp Clin Cancer Res, 2017; 36:12.
63.
SongJ, HuangY, ZhengW, et al.Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway. Front Med, 2018; 12:697–706.
64.
MariñoG, Niso-SantanoM, BaehreckeEH, et al.Self-consumption: The interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol, 2014; 15:81–94.
65.
RubinszteinDC, MariñoG, KroemerG. Autophagy and aging. Cell, 2011; 146:682–695.
66.
ZhuX, ChuH, JiangS, et al.Sirt1 ameliorates systemic sclerosis by targeting the mTOR pathway. J Dermatol Sci, 2017; 87:149–158.
67.
DohKC, KimB-M, KimKW, et al.Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression. BMC Complement Altern Med, 2019; 19:54.
68.
BhullarKS, HubbardBP. Lifespan and healthspan extension by resveratrol. Biochim Biophys Acta, 2015; 1852:1209–1218.
69.
TakaradaT, NakamichiN, NakazatoR, et al.Possible activation by the green tea amino acid theanine of mammalian target of rapamycin signaling in undifferentiated neural progenitor cells in vitro. Biochem Biophys Reports, 2016; 5:89–95.
70.
BrownMK, NaidooN. The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol, 2012; 3:263.
71.
HolczerM, BeszeB, ZámbóV, et al.Epigallocatechin-3-gallate (EGCG) promotes autophagy-dependent survival via influencing the balance of mTOR-AMPK pathways upon endoplasmic reticulum stress. Oxid Med Cell Longev, 2018; 2018:1–15.
72.
LiuH, YangJ, LiL, et al.The natural occurring compounds targeting endoplasmic reticulum stress. Evid Based Complement Altern Med, 2016; 2016:1–13.