Nutrition and Nutritional Supplements in the Management of Dyslipidemia—Part 2

Houston M . The role of nutrition and nutritional supplements in the treatment of dyslipidemia. Clin Lipidol, 2014; 9:333–354.

Estruch R , Ros E , Salas-Salvadó J , et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med, 2013; 368:1279–1290.

Ried K , Toben C , Fakler P . Effect of garlic on serum lipids: An updated meta-analysis. Nutr Rev, 2013; 71:282–299.

Houston MC . Juice powder concentrate and systemic blood pressure, progression of coronary artery calcium and antioxidant status in hypertensive subjects: A pilot study. Evid Based Complementary Alternat Med, 2007; 4:455–462.

Alexander DD , Miller PE , Van Elswyk ME , et al. A meta-analysis of randomized controlled trials and prospective cohort studies of eicosapentaenoic and docosahexaenoic long-chain omega-3 fatty acids and coronary heart disease risk. Mayo Clin Proc, 2017; 92:15–29.

Rissanen T , Voutilainen S , NyyssonenK, et al. Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary events: The Kuopio ischaemic heart disease risk factor study. Circulation, 2000; 102:2677–2679.

Davis W , Rockway S , Kwasny M . Effect of a combined therapeutic approach of intensive lipid management, omega 3 fatty acid supplementation, and increased serum 25(OH) D on coronary calcium scores in asymptomatic adults. Am J Ther, 2009; 16:326–332.

Yokoyama M , Origasa H , Matsuzaki M , et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis. Lancet, 2007; 369:1090–1098.

Ryan AS , Keske MA , Hoffman JP , Nelson EB . Clinical overview of algal-docosahexaenoic acid: Effects on triglyceride levels and other cardiovascular risk factors. Am J Ther, 2009; 16:183–192.

Kelley DS , Siegal D , Vemuri M , et al. Docosahexaenoic acid supplementation decreases remnant-like particle cholesterol and increases the (n-3) index in hypertriglyceridemic men. J Nutr, 2008; 138:30–35.

Maki KC , Dicklin MR , Davidson MH , et al. Baseline lipoprotein lipids and low-density lipoprotein cholesterol response to prescription omega-3 acid ethyl ester added to simvastatin therapy. Am J Cardiol, 2010; 105:1409–1412.

Micallef MA , Garg ML . The lipid-lowering effects of phytosterols and (n-3) polyunsaturated fatty acids are synergistic and complementary in hyperlipidemic men and women. J Nutr, 2008; 138:1085–1090.

Mori TA , Burke V , Puddey IB , et al. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose and insulin in mildly hyperlipidemic men. Am J Clin Nutr, 2000; 71:1085–1094.

Aung T , Halsey J , Kromhout D , et al. Associations of Omega-3 fatty acid supplement use with cardiovascular disease risks: Meta-analysis of 10 trials involving 77,917 individuals. JAMA Cardiol, 2018; 3:225–234.

Abdelhamid AS , Brown TJ , Brainard JS , et al. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev, 2018; 7:CD003177.

Prasad K . Flaxseed and cardiovascular health. J Cardiovasc Pharmacol, 2009; 54:369–377.

Bioedon LT , Balkai S , Chittams J , et al. Flaxseed and cardiovascular risk factors: Results from a double-blind, randomized controlled clinical trial. J Am Coll Nutr, 2008; 27:65–74.

Mandasescu S , Mocanu V , Dascalita AM , et al. Flaxseed supplementation in hyperlipidemic patients. Rev Med Chir Soc Med Nat Iasi, 2005; 109:502–506.

Llorente-Cortés V , Estruch R , Mena MP , et al. Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk. Atherosclerosis, 2010; 208:442–450.

Razquin C , Martinez JA , Martinez-Gonzalez MA , et al. A Mediterranean diet rich in virgin olive oil may reverse the effects of the -174G/C IL6 gene variant on 3-year body weight change. Mol Nutr Food Res, 2010; 54:S75–S82.

Bester D , Esterhuyse AJ , Truter EJ , van Rooven J . Cardiovascular effects of edible oils: A comparison between four popular edible oils. Nutr Res Rev, 2010; 23:334–348.

Vafeiadou K , Weech M , Altowaijri H , et al. Replacement of saturated with unsaturated fats had no impact on vascular function but beneficial effects on lipid biomarkers, E-selectin, and blood pressure: Results from the randomized, controlled Dietary Intervention and VAScular function (DIVAS) study. Am J Clin Nutr, 2015; 102:40–48.

Bogani P , Gali C , Villa M , Visioli F . Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosis, 2007; 190:181–186.

Reid K . Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: An updated meta-analysis and review. J Nutr, 2016; 146:389S–396S.

Samavat H , Newman AR , Wang R , et al. Effects of green tea catechin extract on serum lipids in postmenopausal women: A randomized, placebo-controlled clinical trial. Am J Clin Nutr, 2016; 104:1671–1682.

Tinahones FJ , Rubio MA , Garrido-Sanchez L , et al. Green tea reduces LDL oxidizability and improves vascular function. J Am Coll Nutr, 2008; 27:209–213.

Brown AL , Lane J , Holyoak C , et al. Health effects of green tea catechins in overweight and obese men: A randomized controlled cross-over trial. Br J Nut, 2011; 7:1–10.

Zheng XX , Xu YL , Li SH , et al. Green tea intake lowers fasting serum total and LDL cholesterol in adults: A meta-analysis of 14 randomized controlled trials. Am J Clin Nutr, 2011; 94:601–610.

Cesar TB , Aptekman NP , Araujo MP , et al. Orange juice decreases low-density lipoprotein cholesterol in hypercholesterolemic subjects and improves lipid transfer to high-density lipoprotein in normal and hypercholesterolemic subjects. Nutr Res, 2010; 30:689–694.

Mirmiran P , Fazeli MR , Asghari G , et al. Effect of pomegranate seed oil on hyperlipidaemic subjects: A double-blind placebo-controlled clinical trial. Br J Nutr, 2010; 104:402–406.

Fuhrman B , Volkova N , Aviram M . Pomegranate juice polyphenols increase recombinant paroxonase-1 binding to high density lipoprotein: Studies in vitro and in diabetic patients. Nutrition, 2010; 26:359–366.

Avairam M , Rosenblat M , Gaitine D , et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr, 2004; 23:423–433.

Mattiello T , Trifiro E , Jotti GS , Pulcinelli FM . Effects of pomegranate juice and extract polypyenols on platelet function. J Med Food, 2009; 12:334–339.

Aviram M , Dornfeld L , Rosenblat M , et al. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: Studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr, 2000; 71:1062–1076.

Davidson MH , Maki KC , Dicklin MR , et al. Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease. Am J Cardiol, 2009; 104:936–942.

Devarajan S , Singh R , Chatterjee B , et al. A blend of sesame oil and rice bran oil lowers blood pressure and improves the lipid profile in mild-to-moderate hypertensive patients. J Clin Lipidol, 2016; 10:339–349.

Namiki M . Nutraceutical functions of sesame: A review. Crit Rev food Sci Nutr, 2007; 47:651–673.

Sacks FM , Lichtenstein A , Van Horn L , et al. Soy protein, isoflavones, and cardiovascular health: An American Heart Association Science Advisory for professionals from the Nutrition Committee. Circulation, 2006; 113:1034–1044.

Harland JI , Haffner TA . Systemic review, meta-analysis and regression of randomized controlled trials reporting an association between an intake of circa 25 g soya protein per day and blood cholesterol. Atherosclerosis, 2008; 200:13–27.

Toth PP , Patti AM , Nikolic D , et al. Bergamot reduces plasma lipids, atherogenic small dense LDL, and subclinical atherosclerosis in subjects with moderate hypercholesterolemia: A 6 months prospective study. Front Pharmacol, 2016; 6:299.

Mollace V , Sacco I , Janda E , et al. Hypolipidemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies. Fitotherapia, 2011; 82:309–316.

Soni KB , Kuttan R . Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol, 1992; 36:273–275.

Ulbricht C , Basch E , Szapary P , et al. Guggul for hyperlipidemia: A review by the Natural Standard Research Collaboration. Complement Ther Med, 2005; 13:279–290.

Nohr LA , Rasmussen LB , Straand J . Resin from the Mukul Myrrh tree, guggul, can it be used for treating hypercholesterolemia: A randomized, controlled study. Complement Ther Med, 2009; 17:16–22.

McEneny J , Wade L , Young IS , et al. Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals. J Nutr Biochem, 2013; 24:163–168.

Palozza P , Simone R , Gatalano A , et al. Lycopene regulation of cholesterol synthesis and efflux in human macrophages. J Nutr Biochem, 2011; 22:971–978.

Ruparelia N , Digby JE , Choudhury RP . Effects of niacin on atherosclerosis and vascular function. Curr Opin Cardiol, 2011; 26:66–70.

Al-Mohissen MA , Pun SC , Frohlich JJ . Niacin: From mechanisms of action to therapeutic uses. Mini Rev Med Chem, 2010; 10:204–217.

Garg A , Sharma A , Krishnamoorthy P , et al. Role of niacin in current clinical practice: A systematic review. Am J Med, 2017; 130:173–187.

Lavigne PM , Karas RH . The current state of niacin in cardiovascular disease prevention: A systematic review and meta-regression. J Am Coll Cardiol, 2013; 61:440–446.

Khera AV , Qamar A , Reilly MP , et al. Effects of niacin, statin, and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 levels in patients with dyslipidemia. Am J Cardiol, 2015; 115:178–182.

Houston M , Pizzorno J . “Niacin doesn't work and is harmful!” proclaim the headlines. Yet another highly publicized questionable study to discredit integrative medicine. Integr Med (Encinitas), 2014; 13:8–11.

AIM HIGH Investigators. The role of niacin in raising high density lipoprotein cholesterol to reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low density lipoprotein cholesterol: Baseline characteristics of study participants. The Atherothrombosis Intervention in Metabolic syndrome with low HDL/high triglycerides: Impact on Global Health outcomes (AIM-HIGH) trial. Am Heart J, 2011; 161:538–543.

Plourde M , Vohl MC , Vandal M , et al. Plasma n-3 fatty acid supplement is modulated by apoE epsilon 4 but not by the common PPAR-alpha L162 polymorphism in men. Br J Nutr, 2009; 102:1121–1124.

McRae MP . Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutr Res, 2005; 25:319–333.

Kelly G . Pantethine: A review of its biochemistry and therapeutic applications. Altern Med Rev, 1997; 2:365–377.

Rumberger JA , Napolitano J , Azumano I , et al. A derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: A triple-blinded placebo and diet-controlled investigation. Nutr Res, 2011; 31:608–615.

Evans M , Rumberger JA , Azumano I , et al. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: A triple-blinded placebo and diet-controlled investigation. Vasc Health Risk Manag, 2014; 10:89–100.

Pantethine monograph. Altern Med Rev, 2010; 15:279–282.

Plat J , Baumgartner S , Mensink RP . Mechanisms underlying the health benefits of plant sterol and stanol ester consumption. J AOAC Int, 2015; 98:697–700.

Demonty I , Ras RT , van der Knaap HC , et al. Continuous dose response relationship of the LDL cholesterol lowering effect of phytosterol intake. J Nutr, 2009; 139:271–284.

Sabeva NS , McPhaul CM , Li X . Phytosterols differentially influence ABC transporter expression, cholesterol efflux and inflammatory cytokine secretion in macrophage foam cells. J Nutr Biochem, 2011; 22:777–783.

Kim JY , Kim SM , Kim SJ , et al. Consumption of policosanol enhances HDL functionality via CETP inhibition and reduces blood pressure and visceral fat in young and middle-aged subjects. Int J Mol Med, 2017; 39:889–899.

Berthold HK , Unverdorben S , Degenhardt R , et al. Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: A randomized controlled trial. JAMA, 2006; 295:2262–2269.

Greyling A , De Witt C , Oosthuizen W , Jerling JC . Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr, 2006; 95:968–975.

Solomenchuk TM , Vosukh V , Bedzay A , et al. [Efficiency of concomitant use of policosanol and rosuvastatin in patients with stable coronary artery disease and moderate hepatic dysfunction.]. Lik Sprava, 2015; 29–37.

Qureshi AA , Sami SA , Salser WA , Khan FA . Synergistic effect of tocotrienol-rich fraction (TRF 25) of rice bran and lovastatin on lipid parameters in hypercholesterolemic humans. J Nutr Biochem, 2001; 12:318–329.

Prasad K . Tocotrienols and cardiovascular health. Curr Pharm Des, 2011; 17:2147–2154.

Cicero AFG . [Red yeast rice, monacolin K, and pleiotropic effects.]. Recenti Prog Med, 2018; 109:154e–157e.

Xiong X , Wang P , Li X , et al. The effects of red yeast rice dietary supplement on blood pressure, lipid profile, and C-reactive protein in hypertension: A systematic review. Crit Rev Food Sci Nutr, 2017; 57:1831–1851.

McRae MP . Vitamin C supplementation lowers serum low-density cholesterol and triglycerides: A meta-analysis of 13 randomized controlled trials. J Chiropr Med, 2008; 7:48–58.

McRae MP . The efficacy of vitamin C supplementation on reducing total serum cholesterol in human subjects: A review of 51 experimental trials. J Chiropr Med, 2006; 5:2–12.

Sahebkar A , Watts GF . Mode of action of berberine on lipid metabolism: A new-old phytochemical with clinical applications?. Curr Opin Lipidol, 2017; 28:282–283.

Kong W , Wei J , Abidi P , et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med, 2004; 10:1344–1351.

Dong H , Zhao Y , Zhao L , Lu F . The effects of berberine on blood lipids: A systemic review and meta-analysis of randomized controlled trials. Planta Med, 2013; 79:437–446.

McCarty MF , O'Keefe JH , DiNicolantonio JJ . Red yeast rice plus berberine: Practical strategy for promoting vascular and metabolic health. Altern Ther Health Med, 2015; 21:40–45.

Houston M , Sparks W . Effect of combination pantethine, plant sterols, green tea extract, delta-tocotrienol and phytolens on lipid profiles in patients with hyperlipidemia. JANA, 2010; 13:15–20.

Houston M , Rountree R , Lamb J , et al. A placebo-controlled trial of a proprietary lipid-lowering nutraceutical supplement in the management of dyslipidemia. J Biol Regul Homeost Agents, 2016; 30:1115–1123.

Studer M , Briel M , Leimenstoll B , et al. Effect of different anti-lipidemic agents and diets on mortality: A systemic review. Arch Int Med, 2005; 165:725–730.

Nijjar PS , Burke FM , Bioesch A , Rader DJ . Role of dietary supplements in lowering low-density lipoprotein cholesterol: A review. J Clin Lipidol, 2010; 4:248–258.

Cicero AFG , Colletti A , Bajraktari G , et al. Lipid lowering nutraceuticals in clinical practice: Position paper from an International Lipid Expert Panel. Arch Med Sci, 2017; 13:965–1005.

Mannarino MR , Ministrini S , Pirro M . Nutraceuticals for the treatment of hypercholesterolemia. Eur J Intern Med, 2014; 25:592–599.

Feng X , Zhang Y , Xu R , et al. Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages. Atherosclerosis, 2010; 208:396–405.

Wiesner P , Choi SH , Almazan F , et al. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: Possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res, 2010; 107:56–65.

Han R . Plasma lipoproteins are important components of the immune system. Microbiol Immunol, 2010; 54:246–253.

Park K , Seo E . Toenail mercury and dyslipidemia: Interaction with selenium. J Trace Elem Med Biol, 2017; 39:43–49.

Zhou Z , Lu YH , Pi HF , et al. Cadmium exposure is associated with the prevalence of dyslipidemia. Cell Physiol Biochem, 2016; 40:633–643.

Oladipo OO , Ayo JO , Ambali SF , et al. Dyslipdemia induced by chronic low dose co-exposure to lead, cadmium and manganese in rats: The role of oxidative stress. Environ Toxicol Pharmacol, 2017; 53:199–205.

Kim K . Blood cadmium concentration and lipid profile in Korean adults. Environ Res, 2012; 112:225–229.

Jones ML , Martoni CJ , Prakash S . Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: A randomized controlled trial. Eur J Clin Nutr, 2012; 66:1234–1241.