Abstract
Many chronic diseases may have their seeds early in life. Observations from the Dutch famine have taught us that the intrauterine environment is an important determinant of adult health. Birth weight has been related to cardiovascular disease (CVD), hypertension, diabetes, and cancer. Critical phases for adult obesity development include time periods between conception and adolescence. A life course approach to chronic disease prevention includes the study of maternal diet during pregnancy, intrauterine exposures, postnatal growth, and the adolescent period.
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