Role of Dendritic Cells in Graft-Versus-Host Disease

Abstract

A major barrier to successful allogeneic hematopoietic stem cell transplantation is graft-versus-host disease (GVHD). Until recently, the role of antigen presentation in the development of this disorder was unknown. The experimental finding that recipient antigen-presenting cells (APCs) were required for the development of CD8⁺ T cell-dependent GVHD has led to a fundamental reappraisal of our ideas concerning the pathogenesis of this disease. Following transplantation, the origin (donor or recipient), number, lineage, and function of APCs within the recipient are altered significantly. Studies that test the influence of each of these factors upon graft-versus-host responses, including graft-versus-tumor responses, are beginning to emerge and suggest that APCs, such as dendritic cells, constitute a potential target for therapeutic manipulation.