Pulmonary Vascular Responses to Ma Huang Extract

Abstract

Objective:

To test the hypothesis that ma huang induces a pressor response in the pulmonary vascular bed of the cat by activating α ₁-adrenergic receptors

Design:

Prospective vehicle-controlled study.

Setting:

Research laboratory at Texas Tech University School of Medicine, Lubbock, TX.

Subjects:

Intact chest preparation; adult mongrel cats.

Interventions:

The effects of phentolamine, a nonselective α receptor blocker, and prazosin, an α ₁ selective antagonist, were investigated on pulmonary arterial responses to ma huang, phenylepherine, norepinephrine, and U-46619, a thromboxane A₂ mimic.

Measurements and main results:

Lobar arterial perfusion pressure was continuously monitored, electronically averaged, and recorded with constant flow in the isolated left lower lobe vascular bed of the cat. Phentolamine and prazosin significantly reduced vasoconstrictor pulmonary perfusion pressure increases induced by ma huang.

Conclusions:

Ma huang has significant vasopressor activity in the pulmonary vascular bed of the cat meditated predominantly by α ₁-adrenergic receptor activation.