A 6-Base Pair Insertion in the Protease Gene of HIV Type 1 Detected in a Protease Inhibitor-Naive Patient Is Not Associated with Indinavir Treatment Failure

Abstract

Insertions in the protease gene of HIV-1 were rarely found and are not associated with reduced effectiveness of protease inhibitors although they are thought to be selected by protease inhibitor therapy. This is the first report of a 6-basepair insertion in the protease gene prior to protease inhibitor therapy.