Resolution of Selective Antibody Deficiency in a Child with a Lacunar Defect of Immune Recognition of Hemophilus influenzae

Abstract

A child who had Hemophilus influenzae type B (HiB) meningitis with a selective antibody deficiency to Hemophilus influenzae associated with decreased immunoglobulin-A (IgA) and IgG-2 levels is presented. Resolution of the immune deficiency was observed with normalization of serum immunoglobulin and IgG-2 levels at 2.5 years old, normal antibody responses to tetanus toxoid, and unconjugated pneumoccocal immunization, but persistent defect to conjugated HiB immunization until 7 years old.