EDITORS-IN-CHIEF
Jason X.-J. Yuan, MD, PhD, Tucson, USA
Nicholas W. Morrell, MD, Cambridge, UK
DEPUTY EDITORS
Stephen L. Archer, MD, Kingston, Canada
Kurt R. Stenmark, MD, Denver, USA
SENIOR ASSOCIATE EDITOR
Ghazwan Butrous, MD, Canterbury, UK
EDITORIAL ASSOCIATE
Mary E. Reynolds, MA, Tucson, USA
SCIENTIFIC ADVISORY BOARD
Robert F. Grover, MD, PhD, Denver, USA
Joseph Loscalzo, MD, Boston, USA
E. Kenneth Weir, MD, Minneapolis, USA
John B. West, MD, PhD, DSc, San Diego, USA
Magdi H. Yacoub, MD, DSc, FRS, London, UK
ASSOCIATE EDITORS
Paul A. Corris, MD, Newcastle, UK
Candice D. Fike, MD, Salt Lake City, USA
Joe G. N. Garcia, MD, Tucson, USA
Hossein A. Ghofrani, MD, Giessen, Germany
Mark T. Gladwin, MD, Pittsburgh, USA
Sheila G. Haworth, MD, London, UK
Antonio A. Lopes, MD, PhD, São Paulo, Brazil
Evangelos Michelakis, MD, Edmonton, Canada
Qadar Pasha, PhD, Delhi, India
Marlene Rabinovitch, MD, Stanford, USA
Stuart Rich, MD, Chicago, USA
Werner Seeger, MD, Giessen, Germany
Patricia A. Thistlethwaite, MD, PhD, San Diego, USA
Chen Wang, MD, PhD, Beijing, China
Martin R. Wilkins, MD, London, UK
Pulmonary Circulation (ISSN 2045-8932) is published quarterly (March, June, September, and December) by the University of Chicago Press, 1427 East 60th Street, Chicago, Illinois 60637, USA, on behalf of the Pulmonary Vascular Research Institute (PVRI; http://www.pvri.info/).
Pulmonary Circulation is a free and open-access online journal. The print edition is available to members of PVRI and to institutions and libraries. Visit the journal's website at www.journals.uchicago.edu/PC for information about access and options to purchase the e-book edition and print copies. To have the journal listed in your institution's catalog, request that your librarian or other representative contact the University of Chicago Press at subscriptions@press.uchicago.edu
Pulmonary Circulation is abstracted and indexed in PubMed, EBSCOHOST, and JSTOR.
Contact. Contributors may contact the editorial associate, Mary E. Reynolds by e-mail at maryreynolds@email.arizona.edu by telephone at +01.520.626.8350 (fax +01.520.626.7400), or by postal mail at Pulmonary Circulation, c/o Mary E. Reynolds, University of Arizona, PO Box 245215, 1656 East Mabel Street, Tucson, AZ 85724-5215, USA. Manuscripts must be submitted online. Please read the instructions on the journal website, http://www.journals.uchicago.edu/PC. For help with access and technical support, please e-mail help@press.uchicago.edu.
Advertising. Electronic advertisements are accepted: contact eHealthcare Solutions at www.e-healthcaresolutions.com; tel. 609.882.8887 ext. 1; fax 425.671.7796. Ad space is also available in the e-book edition: contact j-advertising@press.uchicago.edu.
Periodicals postage paid at Chicago, Illinois, and at additional mailing offices.
Postmaster: Send address changes to Pulmonary Circulation, University of Chicago Press, Journals Division, PO Box 37005, Chicago, IL 60637, USA.
Permissions. Articles may be copied or otherwise reused without permission only to the extent permitted by Sections 107 and 108 of the U.S. Copyright Law. Permission to copy articles for personal, internal, classroom, or library use may be obtained from the Copyright Clearance Center (www.copyright.com). For all other uses, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale, please contact Permissions Coordinator, Journals Division, University of Chicago Press, 1427 East 60th Street, Chicago, IL 60637, USA; fax: +01.773.834.3489; e-mail: journalpermissions@press.uchicago.edu. Articles in the public domain may be used without permission, but it is customary to contact the author.
COVER PHOTO: Representative computed lung 18F fluorodeoxyglucose (18FDG) positron emission tomography (PET) images from an idiopathic pulmonary arterial hypertension patient. The images were originally acquired with a Siemens TruePoint Biography 64 PET scanner and further processed in nip2. The 18FDG uptake was calculated by a Patlak plot for each voxel (2 mm2), typically 200,000 for a human subject. The 12 consecutive images were generated by selecting voxels with high value (top 25%) in the lung and are represented as heat maps, with colored areas indicating the density of high-valued voxels. The background is taken from the corresponding computed tomography image. Image processed by Lan Zhao and John Cupitt of Experimental Medicine, Imperial College London.