Objective: To describe the case of a person with schizophrenia and agenesis of the corpus callosum.
Conclusion: A 24-year-old Caucasian woman with schizophrenia was incidentally found to have complete agenesis of the corpus callosum. A comprehensive neuropsychiatric assessment allowed management to be specifically tailored to the patient's unique clinical profile.
AicardiJLefebvreJLerique-KoechlinA. A new syndrome: spasminflexion, callosalagenesis, ocular abnormalities. Electroencephalography Clinical Neurophysiology1965; 19: 609–610.
2.
AndermannFAndermannEJoubertMKarpatiGCarpenterSMelansonD. Familial agenesis of corpus callosum with anterior horn cell disease: a syndrome of mental retardation, areflexia, and parparesis. Transactions of the American Neurological Association1972; 97: 242–244.
3.
DanksD MCampbellP EStevensB JMayneVCartwrightE. Menkes’ kinky-hair syndrome: an inherited defect in copper absorption with widespread effects. Paediatrics1972; 50: 188.
4.
SchinzelASchmidW. Hallux duplication, postaxial polydactyly, absence of corpus callosum severe mental retardation and additional anomalies in two unrelated patients. A new syndrome. American Journal of Medical Genetics1980; 6: 241–249.
5.
ShapiroW RWilliamsG HPlumF. Spontaneous recurrent hypothermia accompanying agenesis of corpus callosum. Brain1969; 92: 423–436.
6.
TemtamyS AMeguidN A. Hypogenitalism in acrocallosal syndrome. American Journal of Medical Genetics1989; 32: 301–305.
7.
LassondeMJeevesM A. Callosal Agenesis: A Natural Split Brain?, LassondeMJeevesM A. Plenum Press, New York1994.
8.
DavidA SWacharasindhuALishmanW A. Severe psychiatric disturbance and abnormalities of the corpus callosum: review and case series. Journal of Neurological and Neurosurgical Psychiatry1993; 56: 85–93.
9.
LewisS WReveleyM ADavidA SRonM A. Agenesis of the corpus callosum & schizophrenia: a case report. Psychological Medicine1988; 18: 341–347.
10.
SwayzeV WAndreasenN CEhrhardtJ CYuhW TAlligerR JCohenG A. Developmental abnormalities of the corpus callosum in schizophrenia. Archives of Neurology1990; 47: 805–808.
11.
VelekMWhiteL EWilliamsJ PStaffordR LMarcoL A. Psychosis in a case of corpus callosum agenesis. Alabama Medicine: Journal of the Medical Association of the State of Alabama1988; 58: 27–29.
12.
CrowT. Schizophrenia as a transcallosal misconnection syndrome. Schizophrenia Research1998; 30: 111–114.
13.
DavidA. Schizophrenia and the corpus callosum: developmental, structural and functional relationships. Behavioural Brain Research1994; 64: 203–211.
14.
FilleyC. The Behavioural Neurology of White Matter. Oxford University Press, New York2001.
15.
SwayzeVAndreasenNErhardtJ. Developmental abnormalities of the corpus callosum in schizophrenia. Archives of Neurology1990; 47: 805–808.
16.
ScottT FPriceT RGeorgeM SBrillmanJRothfusW. Midline cerebral malformations and schizophrenia (Review). Journal of Neuropsychiatry and Clinical Neurosciences1993; 5: 287–293.
17.
GuptaSPopliA. Psychosis in Apert's syndrome with partial agenesis of the corpus callosum. Journal of Psychiatry and Neuroscience1995; 20: 307–309.
18.
KraynackNHostofferDRobinN. Agenesis of the corpus callosum association with DiGeorge-velocardiofacial syndrome: a case report and review of the literature. Journal of Child Neurology1999; 14: 754–756.
19.
JeretJ SSerurDWisniewskiK. Agenesis of the corpus callosum and limbic malformations in Apert's Syndrome. Archives of Neurology1989; 46: 10.
20.
JeretJ SSerurDWisniewskiKLubinR A. Clinicopathological findings associated with agenesis of the corpus callosum. Brain and Development1986; 9: 255–264.
21.
EdelstynN MOyebodeFRiddochM JSoppittRMoselhyHGeorgeM. A neuropsychological perspective on three schizophrenia patients with midline structural defects. British Journal of Psychiatry1997; 170: 416–421.
22.
JonesG HMillerJ J. Functional tests of the corpus callosum in schizophrenia. British Journal of Psychiatry1981; 139: 553–557.
23.
DavisKStewartDFriedmanJ. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Archives of General Psychiatry2003; 60: 443–456.
24.
JeretJ SSerurDWisniewskiK. Frequency of agenesis of the corpus callosum in the developmentally disabled population as determined by computerised tomography. Paediatric Neuroscience1986; 12: 101–103.
25.
BurnsJJobDBastinM. Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study. British Journal of Psychiatry2003; 182: 439–443.
26.
NasrallahHAndreasenNCoffmanJ. A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia. Biological Psychiatry1986; 21: 274–282.
27.
RosenthalRBigelowL B. Quantitative brain measurements in chronic schizophrenia. Biological Psychiatry1972; 121: 259–264.
28.
BogertBLeschALangeHZechMTutschJ. Hypotrophy of the corpus callosum in schizophrenia. Neuroscience Letters1990; 34: 534.
29.
JacobsenLGieddJRajapakseJ. Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia. Psychiatry Research1997; 68: 77–86.
30.
WoodruffPPearlsonGGeerM. A computerized magnetic resonance imaging study of corpus callosum morphology in schizophrenia. Psychological Medicine1993; 23: 45–56.
31.
RossiAStrattaPGallucciM. Quantification of corpus callosum and ventricles in schizophrenia with nuclear magnetic resonance imaging: a pilot study. American Journal of Psychiatry1989; 149: 99–101.
32.
DegreefGLantosGBogertsBAshtariMLeibermanJ. Abnormalities of the spetum pellucidum on MR scans in first-episode schizophrenic patients. American Journal of Neuroradiology1992; 13: 835–840.
33.
RossiAStrattaPD'AlbenziL. Quantification of corpus callosum & ventricles in schizophrenia with nuclear magnetic resonance Imaging: a pilot study. American Journal of Psychiatry1989; 146: 99–101.
34.
PearlsonG. Neurobiology of Schizophrenia. Annals of Neurology2000; 48: 556–566.
