Previous studies of antagonistic treatments on delayed response performance by frontal monkeys suffer from a logical flaw in that the treatments may also improve the performance of normal monkeys. In a previous study (Gross and Weiskrantz, 1961) we have shown that meprobamate is without effect on delayed response in normal monkeys, but it does severely depress their discrimination performance. In the current study meprobamate is shown to produce a significant improvement in delayed response in each of three frontal monkeys. Nembutal is also effective. Various interpretations of the results are discussed, the view being favoured that the frontal monkey suffers from an excessive and inappropriately ordered intake of sensory information.
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References
1.
BlumJ.ChowK. L.BlumR. A. (1951). Delayed response performance of monkeys with frontal removals after excitant and sedative drugs. J. Neurophysiol., 195114, 197–202.
2.
DeanW. H.DavisG. D. (1959). Behaviour following caudate lesions in Macaca mulatta. J. Neurophysiol.22, 525–37.
3.
FinanJ. L. (1942). Delayed response with pre-delay reinforcement in monkeys after the removal of the frontal lobes. Amer. J. Psychol.55, 202–14.
4.
GlicksteinM.AroraH.SperryR. W. (1960). Delayed response performance of split brain monkeys with unilateral prefrontal ablation and optic tract section. The Physiologist3, 66.
5.
GrossC. G. (1963a). Comparison of the effects of partial and total lateral frontal lesions on test performance by monkeys. J. comp. physiol. Psychol.56, 41–7.
6.
GrossC. G. (1963b). Effect of food deprivation on performance of delayed response and delayed alternation by normal and brain operated monkeys. J. comp. physiol. Psychol.56, 48–51.
7.
GrossC. G.WeiskrantzL. (1961). The effect of two “tranquillizers” on auditory discrimination and delayed response performance of monkeys. Quart. J. exp. Psychol.13, 34–9.
8.
GrossC. G.WeiskrantzL. (1964). Some changes in behaviour produced by lateral frontal lesions in the macaque. Frontal Cortex and BehaviourAkertK.WarrenJ. M..
9.
LawickaL.KonorskiJ. (1959). Physiological mechanisms of delayed reactions: III. The effects of prefrontal ablations on delayed reaction in dogs. Acta Biol. expt.19, 221–32.
10.
MalmoR. B. (1942). Interference factors in delayed response in monkeys after removal of frontal lobes. J. Neurophysiol.5, 292–308.
11.
MilesR. C.BlomquistA. J. (1960). Frontal lesions and behavioural deficits in monkeys. J. Neurophysiol.23, 471–84.
12.
MishkinM.RosvoldH. E.PribramK. H. (1953). Effects of Nembutal in baboons with frontal lesions. J. Neurophysiol.16, 155–9.
13.
OrbachJ.FischerC. J. (1959). Bilateral resections of frontal granular cortex. Arch. Neural.1, 78–86.
14.
OxburyJ.WeiskrantzL. (1962). Effects of frontal cortex lesions on object discrimination learning by monkeys. Nature195, 310–1.
15.
PribramK. H. (1950). Some physical and pharmacological factors affecting delayed response performance of baboons following frontal lobotomy. J. Neurophysiol.13, 373–82.
16.
RiopelleA. J.PfeifferC. C. (1958). Effects of acute and chronic administration of reserpine on test performance. Arch. Neural. Psychiat.79, 352–8.
17.
RosvoldH. E.DelgadoJ. M. R. (1956). The effect on delayed-alteration test performance of stimulating or destroying electrically structures within the frontal lobes of monkeys. J. comp. physiol. Psychol.49, 365–72.
18.
RuchT. C.ShenkinH. A. (1943). The relation of area 13 on orbital surface of frontal lobes to hyperactivity and hyperphagia in monkeys. J. Neurophysiol.6, 349–60.
19.
WadeM. (1947). The effect of sedatives upon delayed response in monkeys following removal of the prefrontal lobes. J. Neurophysiol.10, 57–61.
20.
WeiskrantzL. (1957). Reserpine and behavioural non-reactivity. Psychotropic DrugsGarattiniS.GhettiV.Amsterdam.
21.
WeiskrantzL.Wilson WmA.Jr. (1956). Effect of reserpine on learning and performance. Science123, 116–8.
22.
WeiskrantzL.MihailovicL.GrossC. G. (1962). Effects of stimulation of front cortex and hippocampus on behaviour in the monkey. Brain85, 489–504.
