Compulsion and impulsivity are both primary features of drug addiction. Based on decades of animal research, we have a detailed understanding of the factors (both environmental and physiological) that influence compulsive drug use, but still know relatively little about the impulsive aspects of drug addiction. This review outlines our current knowledge of the relationship between impulsivity and drug addiction, focusing on cognitive and motor impulsivity, which are particularly relevant to this disorder. Topics to be discussed include the influence of chronic drug administration on impulsivity, the mechanisms that may explain drug-induced impulsivity, and the role of individual differences in the development of impulsive drug use. In addition, the manner in which contemporary theories of drug addiction conceptualize the relationship between impulsivity and compulsion is examined. Most importantly, this review emphasizes a critical role for animal research in understanding the role of impulsivity in the development and maintenance of drug addiction.
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References
1.
AbdollahSCaitlinMCBrienJF (1993). Ethanol neurobehavioural teratogenesis in the guinea pig: Behavioural dysfunction and hippocampal morphological change.Canadian Journal of Physiology and Pharmacology71, 776–782.
2.
AbelEL (1982). In utero alcohol exposure and developmental delay of response inhibition.Alcoholism: Clinical and Experimental Research6, 376.
3.
AdrianiWGranstremOMacriSIzykenovaGDambinovaSLaviolaG (2004). Behavioral and neurochemical vulnerability during adolescence in mice: Studies with nicotine.Neuropsychopharmacology29, 869–878.
4.
AdrianiWLaviolaG (2003). Elevated levels of impulsivity and reduced place conditioning with d-amphetamine: Two behavioral features of adolescence in mice.Behavioral Neuroscience117, 695–703.
5.
AlexanderBKCoambsRBHadawayPF (1978). The effect of housing and gender on morphine self-administration in rats.Psychopharmacology58, 175–179.
6.
American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders(4th ed.). Washington, DC:Prometheus Books.
7.
AndersenSL (2002). Changes in the second messenger cyclic AMP during development may underlie motoric symptoms in attention deficit/hyperactivity disorder (ADHD).Behavioural Brain Research130, 197–201.
8.
AndersenSL (2003). Trajectories of brain development: Point of vulnerability or window of opportunity?.Neuroscience and Biobehavioral Reviews27, 3–18.
9.
AndersenSLArvanitogiannisAPliakasAMLeBlancCCarlezonWA (2005). Altered responsiveness to cocaine in rats exposed to methylphenidate during development.Nature Neuroscience5, 13–14.
10.
BabeKSSerafinWE (1996). Histamine, bradykinin, and their antagonists. In J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon, & A. G. Gilman (Eds.), The pharmacological basis of therapeutics(9th ed., pp. 581–600) New York:McGraw-Hill.
11.
BaerJSSampsonPDBarrHMConnorPDStreissguthAP (2003). A 21-year longitudinal analysis of the effects of prenatal alcohol exposure on young adult drinking.Archives of General Psychiatry60, 377–385.
12.
BaglenovaJBirruSPandiellaNMBreeseCR (2004). An assessment of the long-term developmental and behavioral teratogenicity of prenatal nicotine exposure.Behavioural Brain Research150, 159–170.
13.
BarrattESPattonJH (1983). Impulsivity: Cognitive, behavioral and psychophysiological correlates. In M. Zuckerman (Ed.), Biological basis of sensation seeking, impulsivity and anxiety(pp. 77–116)Hillsdale, NJ:Lawrence Erlbaum Associates, Inc.
14.
BatesMEBowdenSCBarryD (2002). Neurocognitive impairment associated with alcohol use disorders: Implications for treatment.Experimental and Clinical Psychopharmacology10, 193–212.
15.
BaumannMHRaleyTSPartillaJSRothmanRB (1993). Biosynthesis of dopamine and serotonin in the rat brain after repeated cocaine injections: A microdissection mapping study.Synapse14, 40–50.
16.
BeattyWWKatzungVMMorelandVJNixonSJ (1995). Neuropsychological performance of recently abstinent alcoholics and cocaine abusers.Drug and Alcohol Dependence37, 247–253.
17.
BecharaADamasioH (2002). Decision-making and addiction (Part I): Impaired activation of somatic states in substance dependent individuals when pondering decisions with negative future consequences.Neuropsychologia40, 1675–1689.
18.
BecharaADolanSDenburgNHindesAAndersonSWNathanPE (2001). Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers.Neuropsychologia39, 376–389.
19.
BecharaATranelDDamasioH (2000). Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions.Brain123, 2189–2202.
20.
BelejTMajiDSioutisSBarrosHMTNobregaJN (1996). Changes in serotonin and norepinephrine uptake sites after chronic cocaine: Pre- vs. post-withdrawal effects.Brain Research736, 287–296.
21.
BennettAJLeschKPHeilsALongJCLorenzJGShoafSE (2002). et al. Early experience and serotonin transporter gene variation interact to influence primate CNS function.Molecular Psychiatry7, 118–122.
22.
BickelWKMarschDM (2001). Toward a behavioral economic understanding of drug dependence: Delay discounting processes.Addiction96, 73–86.
23.
BirrellJMBrownVJ (2000). Medial frontal cortex mediates perceptual attentional set shifting in the rat.Journal of Neuroscience20, 114320–4324.
24.
BizotJCLe BihanCPuechAJHamonMThiebotM-H (1996). Serotonin and tolerance to delay of reward in rats.Psychopharmacology146, 400–412.
25.
BlanchardRJHebertMADulloogLKaawaloaNNishimuraOBlanchardDC (1998). Acute cocaine effects on stereotypy and defense: An ethnoexperimental approach.Neuroscience and Biobehavioral Reviews23, 179–188.
26.
BlockRIErwinWJGhoneimMM (2002). Chronic drug use and cognitive impairments.Pharmacology, Biochemistry and Behavior73, 491–504.
27.
BollaKIFunderburkFRCadetJL (2000). Differential effects of cocaine and cocaine alcohol on neurocognitive performance.Neurology54, 2285–2292.
28.
BowdenSCCrewsFTBatesMEFals-StewartWAmbroseML (2001). Neurotoxicity and neurocognitive impairments with alcohol and drug-use disorders: Potential roles in addiction and recovery.Alcoholism: Clinical and Experimental Research25, 317–321.
29.
BoyleAEGillKSmithBRAmitZ (1991). Differential effects of an early housing manipulation on cocaine-induced activity and self-administration in laboratory rats.Pharmacology, Biochemistry and Behavior39, 269–274.
30.
BozarthMAMurrayAWiseRA (1989). Influence of housing conditions on the acquisition of intravenous heroin and cocaine self-administration in rats.Pharmacology, Biochemistry and Behavior33, 903–907.
31.
BozarthMAWiseRA (1985). Toxicity associated with long-term intravenous heroin and cocaine self-administration in the rat.Journal of the American Medical Association254, 81–83.
32.
BrodskyBSOquendoMEllisSPHaasGLMaloneKMMannJJ (2001). The relationship of childhood abuse to impulsivity and suicidal behavior in adults with major depression.American Journal of Psychiatry158, 1871–1877.
33.
BrooksSPHennebryGMcAlpinGPNormanGLittleHJ (2002). Nimodipine prevents the effects of ethanol in tests of memory.Neuropsychopharmacology42, 577–585.
34.
BrunnerDHenR (1997). Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice.Annals of New York Academy of Sciences836, 81–105.
35.
BukaSLShenessaEDNiauraR (2003). Elevated risk of tobacco dependence among offspring of mothers who smoked during pregnancy: A 30-year prospective study.American Journal of Psychiatry160, 1978–1984.
36.
BurchettSABannonMJ (1997). Serotonin, dopamine, and norepinephrine transporter to mRNAs: Heterogeneity of distribution and response to “binge” cocaine administration.Molecular Brain Research49, 95–102.
37.
CardinalRNPennicottDRSugathapaiaCLRobbinsTWEverittBJ (2001). Impulsive choice induced in rats by lesions of the nucleus accumbens core.Science292, 2499–2501.
38.
CardinalRNRobbinsTWEverittBJ (2000). The effects of d-amphetamine, chlordiazepoxide, α-flupenthixol and behavioural manipulations on choice of signalled and unsignalled delayed reinforcement in rats.Psychopharmacology152, 362–375.
39.
CarlezonWANestlerEJ (2002). Elevated levels of GluR1 in the midbrain: A trigger for sensitization to drugs of abuse?.Trends in Neuroscience25, 610–615.
40.
ChambersRAPotenzaMN (2003). Neurodevelopment, impulsivity, and adolescent gambling.Journal of Gambling Studies19, 53–84.
41.
ChenKKandelDB (2002). Relationship between extent of cocaine use and dependence among adolescents and adults in the United States.Drug and Alcohol Dependence68, 65–85.
42.
ChenWJMaierSEWestJR (1997). Prenatal alcohol treatment attenuates postnatal cocaine-induced elevation of dopamine concentration in nucleus accumbens: A preliminary study.Neurotoxicology and Teratology19, 39–46.
43.
ChoongKShenR (2004). Prenatal ethanol exposure alters the postnatal development of the spontaneous electrical activity of dopamine neurons in the ventral tegmental area.Neuroscience126, 1083–1091.
44.
ChowTW (2000). Personality in frontal lobe disorders.Current Psychiatry Reports12, 446–451.
45.
ChudasamaYBusseyTJMuirJL (2001). Effects of selective thalamic and prelimbic cortex lesions on two types of visual discrimination and reversal learning.European Journal of Neuroscience14, 1009–1020.
46.
ChudasamaYMuirJL (2001). Visual attention in the rat: A role for the prelimbic cortex and thalamic nuclei?.Behavioral Neuroscience115, 417–428.
47.
ChuganiHRPhelpsMEMazziottaJC (1987). Positron emission tomography study of human brain functional development.Annals of Neurology322, 487–497.
48.
CloningerCRSvarkicDMPrzybeckTR (1993). A psychobiological model of temperament and character.Archives of General Psychiatry50, 975–990.
49.
CohenJDServan-SchreiberD (1992). Context, cortex, and dopamine: A connectionist approach to behavior and biology in schizophrenia.Psychological Review99, 45–77.
50.
ColeBJRobbinsTW (1987). Dissociable effects of lesions to the dorsal or ventral noreadrenergic bundle on the acquisition, performance, and extinction of aversive conditioning.Behavioral Neuroscience101, 476–488.
51.
CollinsSLIzenwasserS (2002). Cocaine differentially alters behavior and neurochemistry in periadolescent versus adult rats.Developmental Brain Research138, 27–34.
52.
CollinsSLIzenwasserS (2004). Chronic nicotine differentially alters cocaine-induced locomotor activity in adolescent vs. adult male and female rats.Neuropharmacology46, 349–362.
53.
CrabbeJCPhillipsTJBuckKJCunninghamCLBelknapJK (1999). Identifying genes for alcohol and drug sensitivity: Recent progress and future directions.Trends in Neuroscience22, 173–179.
54.
CreeseIIversenSD (1974). The role of forebrain dopamine systems in amphetamine induced stereotyped behaviour in the rat.Psychopharmacology239, 345–357.
DalleyJWTheobaldDEEagleDMPassettiFRobbinsTW (2002a). Deficits in impulse control associated with tonically-elevated serotonergic function in rat prefrontal cortex.Neuropsychopharmacology26, 716–728.
57.
DalleyJWTheobaldDEPereiraEALiPMRobbinsTW (2002b). Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity.Psychopharmacology164, 329–340.
58.
DeatherageG (1972). Effects of housing density on alcohol intake in the rat.Physiology and Behavior9, 55–57.
59.
DeleonKRGrimesJMConorDFMelloniRH (2002). Adolescent cocaine exposure and offensive aggression: Involvement of serotonin neural signaling and innervation in male Syrian hamsters.Behavioural Brain Research113, 211–220.
60.
DevenportDLMerrimanVJ (1983). Ethanol and behavioral variability in the radial-arm maze.Psychopharmacology79, 21–24.
61.
de WitHCreanJRichardsJB (2000). Effects of d-amphetamine and ethanol on a measure of behavioral inhibition in humans.Behavioral Neuroscience114, 830–837.
62.
de WitHEnggasserJLRichardsJB (2002). Acute administration of d-amphetamine decreases impulsivity in healthy volunteers.Neuropsychopharmacology27, 813–825.
63.
Di CianoPBlahaCDPhillipsAG (1996). Changes in dopamine oxidation currents in the nucleus accumbens during unlimited-access self-administration of d-amphetamine in rats.Behavioural Pharmacology7, 714–729.
64.
DobbingsJSandsJ (1979). Comparative aspects of the brain growth spurt.Early Human Development3, 79–83.
65.
DotyPde WitH (1995). Effect of setting on the reinforcing and subjective effects of ethanol in social drinkers.Psychopharmacology118, 19–27.
66.
DriscollDCStreissguthAPRileyEP (1990). Prenatal alcohol exposure: Comparability of effects in humans and experimental animals.Neurotoxicology and Teratology12, 231–237.
67.
DworkinSICoCSmithJE (1995). Rat brain neurotransmitter turnover rates altered during withdrawal from chronic cocaine administration.Brain Research682, 116–126.
68.
EvendenJL (1998). The pharmacology of impulsive behaviour in rats: IV. The effects of selective serotonergic agents on a paced fixed consecutive number schedule.Psychopharmacology140, 319–330.
69.
EvendenJL (1999). Impulsivity: A discussion of clinical and experimental findings.Journal of Psychopharmacology13, 180–192.
70.
EvendenJLRyanCN (1996). The pharmacology of impulsive behaviour in rats: The effects of drugs on response choice with varying delays of reinforcement.Psychopharmacology128, 161–170.
71.
EvendenJLRyanCN (1999). The pharmacology of impulsive behaviour in rats: VI. The effects of ethanol and selective serotonergic drugs on response choice with varying delays of reinforcement.Psychopharmacology146, 413–421.
72.
EverittBJDickinsonARobbinsTW (2001). The neuropsychological bases of addictive behaviour.Brain Research Reviews36, 129–138.
73.
EverittBJParkinsonJAOlmsteadMCArroyoMRobledoPRobbinsTW (1999). Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems.Annals of New York Academy of Sciences877, 412–438.
74.
EverittBJRobbinsTW (2000). Second-order schedules of drug reinforcement in rats and monkeys: Measurement of reinforcing efficacy and drug-seeking behavior.Psychopharmacology153, 17–30.
75.
EverittBJWolfME (2002). Psychomotor stimulant addiction: A neural systems perspective.Journal of Neuroscience22, 3312–3320.
76.
FeinGDi SclafaniVMeyerhoffDJ (2002). Prefrontal cortical volume reduction associated with frontal cortex function deficit in 6-week abstinent crack-cocaine dependent men.Drug and Alcohol Dependence68, 87–93.
77.
FeolaTWde WitHRichardsJB (2000). Effects of d-amphetamine and alcohol on a measure of behavioral inhibition in rats.Behavioral Neuroscience114, 838–848.
78.
FillmoreMTRushCR (2002). Impaired inhibitory control of behavior in chronic cocaine users.Drug and Alcohol Dependence66, 265–273.
79.
FillmoreMTVan SelstM (2002). Constraints on information processing under alcohol in the context of response execution and response suppression.Experimental and Clinical Psychopharmacology10, 417–424.
80.
FinnPRJustusANMazasCASteinmetzJE (1999). Working memory, executive processes and the effects of alcohol on go/no-go learning: Testing a model of behavioural regulation and impulsivity.Psychopharmacology146, 465–472.
81.
FlecksteinAEHaugheyHMMetzgerRRKokoshkaJMRiddleELHansonJE (1999). et al. Differential effects of psychostimulants and related agents on dopaminergic and serotonergic transporter function.European Journal of Pharmacology382, 45–49.
82.
FletcherPJ (1993). A comparison of the effects of dorsal or median raphe injections of 8-OH-DPAT in three operant tasks measuring response inhibition.Behavioural Brain Research54, 187–197.
83.
FranklinTRActonPDMaldjianJAGrayJDCroftJRDackisCA (2002). et al. Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients.Biological Psychiatry51, 134–142.
84.
Garcia-MorenoLMConejoNMCapillaACarci-SanchezOSenderekKAriasJL (2002). Chronic ethanl intake and object recognition in young and adult rats.Progress in Neuro-Psychopharmacology and Biological Psychiatry26, 831–837.
85.
GawinFHEllinwoodEH (1988). Cocaine and other stimulants: Actions, abuse, and treatment.New England Journal of Medicine318, 1173–1181.
86.
GendleMHStrawdermanMSMactutusCFBoozeRMLevistskyDAStruppBJ (2003). Impaired sustained attention and altered reactivity to errors in an animal model of prenatal cocaine exposure.Developmental Brain Research147, 85–96.
87.
GerbingDWAhadiSAPattonJH (1987). Toward a conceptualization of impulsivity: Components across the behavioral and self-report domains.Multivariate Behavioral Research22, 357–379.
88.
GlattSJTrksakGHCohenOSSimeoneBPJacksonD (2004). Prenatal cocaine exposure decreases nigrostriatal dopamine release in vitro: Effects of age and sex.Synapse53, 74–89.
89.
GoldsteinRZVolkowND (2002). Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex.American Journal of Psychiatry159, 1642–1652.
90.
GrantSContoreggiCLondonED (2000). Drug abusers show impaired performance in a laboratory test of decision-making.Neuropsychologia38, 1180–1187.
91.
HallFS (1998). Social deprivation of neonatal, adolescent and adult rats has distinct neurochemical and behavioral consequences.Critical Reviews in Neurobiology12, 129–162.
92.
HallFSHuangSFongGWPertALinnoilaM (1998a). Effects of isolation-rearing on locomotion, anxiety and responses to ethanol in Fawn Hooded and Wistar rats.Psychopharmacology139, 203–209.
93.
HallFSHuangSFongGWPertALinnoilaM (1998b). Effects of isolation-rearing on voluntary consumption of ethanol, sucrose and saccharin solutions in Fawn Hooded and Wistar rats.Psychopharmacology139, 210–216.
94.
HarrisonAAEverittBJRobbinsTW (1997). Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: Interactions with dopaminergic mechanisms.Psychopharmacology133, 329–342.
95.
HarrisonPAFulkersonJABeebeTJ (1997). Multiple substance use among adolescent physical and sexual abuse victims.Child Abuse and Neglect21, 529–539.
96.
HarrisonPAFulkersonBABeebeTJ (2003). DSM-IV substance use disorder criteria for adolescents: A critical examination based on a statewide school survey.American Journal of Psychiatry155, 486–492.
97.
HarveyJA (2004). Cocaine effects on the developing brain: Current status.Neuroscience and Biobehavioral Reviews27, 751–764.
98.
HaywardMLMartinAEBreinJFDringenbergHCOlmsteadMCReynoldsJN (2004). Chronic prenatal ethanol exposure impairs conditioned responding and enhances GABA release in the hippocampus of the adult guinea pig.Journal of Pharmacology and Experimental Therapeutics308, 644–650.
99.
HeinzAMannKWeinbergerDRGoldmanD (2001). Serotonergic dysfunction, negative mood states, and response to alcohol.Alcoholism: Clinical and Experimental Research25, 487–495.
100.
HellemansKGCNobregaJNOlmsteadMC (2005). Early environmental experience alters baseline and ethanol-induced cognitive impulsivity: Relationship to forebrain 5-HT1A receptor binding.Behavioural Brain Research159, 207–220.
101.
HellemansKGCShahamYOlmsteadMC (2002). Dissociable effects of acute and chronic opiate abstinence on drug-seeking and drug-taking.Canadian Journal of Experimental Psychology56, 241–252.
102.
Hellstrom-LindahlENobergA (2002). Smoking during pregnancy: A way to transfer the addiction to the next generation?.Respiration69, 289–293.
103.
HigleyJDLinnoilaM (1997). A nonhuman primate model of excessive alcohol intake. Personality and neurobiological parallels of type I- and type II-like alcoholism.Recent Developments in Alcohol13, 191–219.
104.
HillSYPowellBJ (1976). Cocaine and morphine self-administration: Effects of differential rearing.Pharmacology, Biochemistry and Behavior5, 701–704.
105.
HoakenPNAssaadJMPhilRO (1998). Cognitive functioning and the inhibition of alcohol-induced aggression.Journal of Studies on Alcohol59, 599–607.
106.
HobbsWRRallTWVerdoornTA (1996). Hypnotics and sedatives: Ethanol. In J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon, & A. Goodman Gilman (Eds.), Goodman and Gilman's the pharmacological basis of therapeutics(9th ed., pp. 361–398) New York:McGraw-Hill.
107.
HombergJvan den AkkerMRaasoHWardehGBinnekadeRSchoffelmeerANM (2002). et al. Enhanced motivation to self-administer cocaine is predicted by self-grooming behaviour and relates to dopamine release in the rat medial prefrontal cortex and amygdala.European Journal of Neuroscience15, 1542–1550.
108.
HommerDWAndreasenPRioDWilliamsWRuttimannYMomenanR (1997). et al. Effects of m-chlorophenylpiperazine on regional brain glucose utilization: A positron emission tomographic comparison of alcoholic and control subjects.Journal of Neuroscience17, 2796–2806.
109.
HowesSRDalleyJWMorrisonCHRobbinsTWEverittBJ (2000). Leftward shift in the acquisition of cocaine self-administration in isolation-reared rats: Relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal FOS expression.Psychopharmacology151, 55–63.
110.
HutchesonDMEverittBJRobbinsTWDickinsonA (2001). The role of withdrawal in heroin addiction: Enhances reward or promotes avoidance?.Nature Neuroscience4, 943–947.
111.
HymanSEMalenkaRC (2001). Addiction and the brain: The neurobiology of compulsion and its persistence.Nature Reviews2, 695–703.
112.
IqbalUDringenbergHCBrienJFReynoldsJN (2004). Chronic prenatal ethanol exposure alters hippocampal GABA(A) receptors and impairs spatial learning in the guinea pig.Behavioural Brain Research150, 117–125.
113.
JacobsEHSmitABDe VriesTSchoffelmeerANM (2003). Neuroadapative effects of active versus passive drug administration in addiction research.Trends in Pharmacological Sciences24, 566–573.
114.
JacobsenLKStaleyJKMalisonRTZoghbiSSKostenTRInnisRB (2000). Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients.American Journal of Psychiatry157, 1134–1140.
115.
JentschJDOlaussonPDe La GarzaRTaylorJR (2002). Impairments of reversal learning and response perseveration after repeated, intermittent cocaine administrations to monkeys.Neuropsychopharmacology26, 183–190.
116.
JentschJDTaylorJR (1999). Impulsivity resulting from frontostriatal dysfunction in drug abuse: Implications for the control of behavior by reward-related stimuli.Psychopharmacology146, 373–390.
117.
JentschJDTaylorJR (2003). Sex-related differences in spatial divided attention and motor impulsivity in rats.Behavioral Neuroscience117, 76–83.
118.
JohnsonRGFiorellaDRabinRA (1993). Effects of chronic cocaine administration on the serotonergic system in the rat brain.Pharmacology, Biochemistry and Behavior46, 289–293.
119.
KalivasPWSorgBAHooksMS (1993). The pharmacology and neural circuitry of sensitization to psychostimulants.Behavioural Pharmacology4, 315–334.
120.
KandelDBYamaguchiKChenK (1992). Stages of progression in drug involvement from adolescence to adulthood: Further evidence for the gateway theory.Journal of Studies on Alcohol53, 447–457.
121.
KaneVGFuYMattaSGSharpBM (2004). Gestational nicotine exposure attenuates nicotine-stimulated dopamine release in the nucleus accumbens shell of adolescent Lewis rats.Journal of Pharmacology and Experimental Therapeutics308, 521–528.
122.
KazmaierKButcherRESenterRJStutzRM (1973). Rearing conditions and ethanol consumption by rats.Quarterly Journal of Studies on Alcohol34, 520–524.
123.
KellerRWLeFevreRRaucciJCarlsonJN (1996). Enhanced cocaine self-administration in adult rats prenatally exposed to cocaine.Neuroscience Letters205, 153–156.
124.
KelleyAEBerridgeKC (2002). The neuroscience of natural rewards: Relevance to addictive drugs.Journal of Neuroscience22, 3306–3311.
125.
KilbeyMMEllinwoodEH (1977). Chronic administration of stimulant drugs: Response modification. In E. H. Ellinwood (Ed.), Advances in behavioural biology(pp. 409–429)New York:Plenum Press.
126.
KirbyKNPetryNMBickelWK (1999). Heroin addicts have higher discount rates for delayed rewards than non-drug using controls.Journal of the Experimental Analysis of Behavior128, 78–87.
127.
KishSJ (2002). How strong is the evidence that brain serotonin neurons are damaged in human users of Ecstasy?.Pharmacology, Biochemistry and Behavior71, 845–855.
128.
KlevenMSWoolvertonWLSeidenL (1988). Lack of long-term monoamine depletions following repeated or continuous exposure to cocaine.Brain Research Bulletin21, 233–237.
129.
KlitzmanRLPopeHGJr.HudsonJI (2000). MDMA (“Ecstasy”) abuse and high-risk sexual behaviors among 169 gay and bisexual men.American Journal of Psychiatry157, 1162–1164.
130.
KodituwakkuPWMayPAClericuuzioCLWeersD (2001). Emotion-related learning in individuals prenatally exposed to alcohol: An investigation of the relation between set shifting, extinction of responses, and behaviour.Neuropsychologia39, 699–708.
131.
KoobGFLe MoalM (2001). Drug addiction, dysregulation of reward, and allostasis.Neuropsychopharmacology24, 97–129.
132.
KuczenskiRSegalDS (1997). An escalating dose/multiple high-dose binge pattern of amphetamine administration results in differential changes in the extracellular dopamine response profiles in caudate-putamen and nucleus accumbens.Journal of Neuroscience17, 4441–4447.
133.
LauMAPihlROPetersonJB (1995). Provocation, acute alcohol intoxication, cognitive performance and aggression.Journal of Abnormal Psychology104, 150–155.
134.
LaviolaGMacriSMorley-FletcherSAdrianiW (2003). Risk-taking behavior in adolescent mice: Psychobiological determinants and early epigenetic influence.Neuroscience and Biobehavioral Reviews27, 19–31.
135.
LaviolaGWoodRDKuhnCFrancisRSpearLP (1995). Cocaine sensitization in periadolescent and adult rats.Journal of Pharmacology and Experimental Therapeutics275, 345–357.
136.
LeschKPMerschdorfU (2000). Impulsivity, aggression, and serotonin: A molecular psychobiological perspective.Behavioural Sciences and the Law18, 581–604.
137.
LeshnerAI (2000). Vulnerability to addiction: New research opportunities.American Journal of Medical Genetics96, 590–591.
138.
LindholmSRosinADahlinIGeorgievaJFrankJ (2001). Ethanol administration potentiates cocaine-induced dopamine levels in the rat nucleus accumbens.Brain Research915, 176–184.
139.
LittleKYMcLaughlinDPZhangLLivermoreCSDalackGWMcFintonPR (1998). et al. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels.American Journal of Psychiatry155, 207–213.
140.
LittleKYPatelUNClarkTBButtsJD (1996). Alterations of brain dopamine and serotonin levels in cocaine users: A preliminary report.American Journal of Psychiatry153, 1216–1218.
141.
LondonEDErnstMGrantSBonsonKWeinsteinA (2000). Orbitofrontal cortex and human drug abuse: Functional imaging.Cerebral Cortex10, 334–342.
142.
LovingerDM (1999). 5-HT-sub-3 receptors and the neural actions of alcohol: An increasingly exciting topic.Neurochemistry International35, 125–130.
143.
MacDonaldTKFongGTZannaMPMartineauAM (2000). Alcohol myopia and condom use: Can alcohol intoxication be associated with more prudent behavior?.Journal of Personality and Social Psychology78, 605–619.
144.
MacDonaldTKZannaMPFongGT (1996). Why comon sense goes out the window: Effects of alcohol on intentions to use condoms.Personality and Social Psychology Bulletin22, 763–775.
145.
MaddenGJPetryNMBadgerGJBickelWK (1997). Impulsive and self-control choices in opioid-dependent patients and non-drug-using control participants: Drug and monetary rewards.Experimental and Clinical Psychopharmacology5, 256–262.
146.
MaisonneuveIMKreekMJ (1994). Acute tolerance to the dopamine release induced by a binge pattern of cocaine administration in male rats: An in-vivo microdialysis study.Journal of Pharmacology and Experimental Therapeutics268, 916–921.
147.
MarinelliMPiazzaPV (2002). Interaction between glucocorticoid hormones, stress and psychostimulant drugs.European Journal of Neuroscience16, 387–394.
148.
MarkouA (1998). Neurobiological similarities in depression and drug dependence: A self-medication hypothesis.Neuropsychopharmacology18, 135–174.
149.
MarkouAWeissFGoldLHCaineSBSchulteisGKoobGF (1993). Animal models of drug craving.Psychopharmacology112, 163–182.
150.
MartenssonL (1984). The pregnant rabbit, guinea pig, sheep and rhesus monkey as models in reproductive physiology.European Journal of Obstetrics and Gynecological Reproductive Biology18, 169–182.
151.
MattsonSNRileyEP (1998). A review of the neurobehavioral deficits in children with Fetal Alcohol Syndrome or prenatal exposure to alcohol.Alcoholism: Clinical and Experimental Research22, 279–294.
152.
MattsonSNSchoenfeldAMRileyEP (2001). Teratogenic effects of alcohol on brain and behavior.Alcohol Research and Health25, 185–191.
153.
McCannUDRidenourAShahamYRicaurteGA (1997). Serotonin neurotoxicity after (+)-3,4-methlyenedioxymethamphetamine (MDMA: “Ecstasy”): A controlled study in humans.Neuropsychopharmacology10, 129–138.
154.
McClureGMcMillanD (1997). Effects of drugs on response duration differentiation: VI. Differential effects of differential reinforcement of low rates of responding schedules.Journal of Pharmacology and Experimental Therapeutics281, 1368–1380.
155.
MelegaWPQuintanaJRaleighMJStoutDBYuDCLinKP (1996). et al. 6-[18]fluoro-[sal]1-DOPA-PET studies show partial reversibility of long-term effects of chronic amphetamine in monkeys.Synapse22, 63–69.
156.
MillerL (1992). Impulsivity, risk-taking, and the ability to synthesize fragmented information after frontal lobectomy.Neuropsychologia30, 69–79.
157.
MitchellSH (1999). Measures of impulsivity in cigarette smokers and non-smokers.Psychopharmacology146, 455–464.
158.
MoellerFGDoughertyDMBarrattESOderindeVMathiasCWHarperRA (2002). et al. Increased impulsivity in cocaine dependent subjects independent of antisocial personality disorder and aggression.Drug and Alcohol Dependence68, 105–111.
159.
MorganMJ (1998). Recreational use of Ecstasy (MDMA) is associated with elevated impulsivity.Neuropsychopharmacology19, 252–264.
160.
MorganMJ (2000). Ecstasy (MDMA): A review of its possible persistent psychological effects.Psychopharmacology152, 230–248.
161.
MorralARMcCaffreyDFPaddockSM (2002). Reassessing the marijuana gateway effect.Addiction97, 1493–1504.
162.
NadalRArmarioAJanakPH (2002). Positive relationship between activity in a novel environment and operant ethanol self-administration in rats.Psychopharmacology162, 333–338.
163.
NansonJLHiscockM (1990). Attention deficits in children exposed to alcohol prenatally.Alcoholism: Clinical and Experimental Research14, 656–661.
164.
NeddensJLestingJDawirsRRTeuchert-NoodtG (2002). An early methampethamine challenge suppresses the maturation of dopamine fibres in the nucleus accumbens of gerbils: On the significance of rearing condition.Journal of Neural Transmission109, 141–155.
O'BoyleMBarrattES (1993). Impulsivity and DSM-III-R personality disorders.Personality and Individual Differences14, 609–611.
167.
OlmsteadMCHellemansKGCPaineTA (in press). Alcohol induced impulsivity in rats: An effect of cue salience?.Psychopharmacology.
168.
OlmsteadMCLafondMVEverittBJDickinsonA (2001). Cocaine-seeking by rats is a goal directed action.Behavioral Neuroscience115, 394–402.
169.
OlmsteadMCParkinsonJAMilesFEverittBJDickinsonA (2000). Cocaine-seeking by rats: Regulation, reinforcement and activation.Psychopharmacology152, 123–131.
170.
OrnsteinTJIddonJLBaldacchinoASahakianBJLondonMEverittBJ (2000). et al. Profiles of cognitive dysfunction in chronic amphetamine and heroin abusers.Neuropsychopharmacology23, 113–126.
171.
OrtnerCNMacDonaldTKOlmsteadMC (2003). Alcohol intoxication reduces impulsivity in a delay discounting paradigm.Alcohol and Alcoholism38, 151–156.
172.
PaineTADringenbergHCOlmsteadMC (2003). Effects of chronic cocaine on impulsivity: Relation to cortical serotonin mechanisms.Behavioural Brain Research147, 135–147.
173.
PaineTAMcElvieBDringenbergHCOlmsteadMC (2004). Chronic cocaine impairs reversal learning in the attentional set-shifting paradigm.Society for Neuroscience Abstracts.
174.
PaineTAOlmsteadMC (2003). Impaired response inhibition and conditional discrimination following acute cocaine administration.Psychopharmacology175, 443–450.
175.
PausT (2005). Mapping brain maturation and cognitive development during adolescence.Trends in Cognitive Sciences9, 60–68.
176.
PausTZijdenbosAWorsleyKCollinsDLBlumenthalJGieddJN (1999). et al. Structural maturation of neural pathways in children and adolescents: An in vivo study.Science283, 1908–1911.
177.
PetryNM (2001). Substance abuse, pathological gambling, and impulsiveness.Drug and Alcohol Dependence63, 29–38.
178.
PhillipsGDHowesSRWhitelawRBRobbinsTWEverittBJ (1994a). Isolation rearing impairs the reinforcing efficacy of intravenous cocaine or intra-accumbens d-amphetamine: Impaired response to intra-accumbens D1 and D2/D3 dopamine receptor antagonists.Psychopharmacology115, 419–429.
179.
PhillipsGDHowesSRWhitelawRBWilkinsonLSRobbinsTWEverittBJ (1994b). Isolation rearing enhances the locomotor response to cocaine and a novel environment, but impairs the intravenous self-administration of cocaine.Psychopharmacology115, 407–418.
180.
PiazzaPVLe MoalM (1996). Pathophysiological basis of vulnerability to drug abuse: Role of an interaction between stress, glucocorticoids, and dopaminergic neurons.Annual Review of Pharmacology and Toxicology36, 359–378.
181.
PitmanPK (1989). Animal models of compulsive behavior.Biological Psychiatry26, 189–198.
182.
PoulosCXParkerJLLeAD (1996). Dexfenfluramine and 8-OH-DPAT modulate impulsivity in a delay-of-reward paradigm: Implications for a correspondence with alcohol consumption.Behavioural Pharmacology7, 395–399.
183.
PoulosCXParkerJLLeDA (1998). Increased impulsivity after injected alcohol predicts later alcohol consumption in rats: Evidence for “loss-of-control drinking” and marked individual differences.Behavioral Neuroscience112, 1247–1257.
184.
RamseyNFNiesinkRJVan ReeJM (1993). Prenatal exposure to morphine enhances cocaine and heroin self-administration in drug-naive rats.Drug and Alcohol Dependence33, 41–51.
185.
RandrupAScheel-KrugerJ (1966). Diethyldithiocarbamate and amphetamine stereotype behaviour.Journal of Pharmacy and Pharmacology18, 752.
RenemanLBooijJSchmandBvan den BrinkWGunningB (2000). Memory disturbances in “Ecstasy” users are correlated with an altered brain serotonin neurotransmission.Psychopharmacology148, 322–324.
188.
RenemanLMajoieCBLMSchmandBvan den BrinkWden HeetenGJ (2001). Prefrontal N-acetylaspartate is strongly associated with memory performance in (abstinent) ecstasy users: Preliminary report.Biological Psychiatry50, 550–554.
189.
RichardsJBSabolKEde WitH (1999a). Effects of methamphetamine on the adjusting amount procedure, a model of impulsive behavior in rats.Psychopharmacology146, 432–439.
190.
RichardsJBZhangLMitchellSde WitH (1999b). Delay or probability discounting in a model of impulsive behavior: Effect of alcohol.Journal of the Experimental Analysis of Behavior71, 121–143.
191.
RichardsonDPByrnesMLBrienJFReynoldsJNDringenbergHC (2002). Impaired acquisition in the water maze and hippocampal long-term potentiation after chronic prenatal ethanol exposure in the guinea pig.European Journal of Neuroscience16, 1593–1598.
192.
RidleyRBakerHWeightM (1980). Amphetamine disrupts successive but not simultaneous visual discriminations in the monkey.Psychopharmacology67, 241–244.
193.
RileyEPLochryEAShapiroNR (1979). Lack of response inhibition in rats prenatally exposed to alcohol.Psychopharmacology41, 652–659.
194.
RileyEPShapiroNRLochryEABroidaAP (1980). Mixed-ratio performance and subsequent extinction in rats prenatally exposed to ethanol.Physiological Psychology8, 27–50.
195.
RobbinsTWJonesGHWilkinsonLS (1996). Behavioural and neurochemical effects of early social deprivation in the rat.Journal of Psychopharmacology10, 39–47.
196.
RobertsDCSLohEABakerGBVickersG (1994). Lesions of central serotonin systems affect responding on a progressive ratio schedule reinforced by either intravenous cocaine or by food.Pharmacology, Biochemistry and Behavior49, 177–182.
197.
RobinsonTEBerridgeKC (1993). The neural basis of drug craving: An incentive-sensitization theory of addiction.Brain Research Reviews18, 247–291.
198.
RobinsonTEBerridgeKC (2003). Addiction.Annual Review of Psychology54, 53.
199.
RobinsonTEGornyGMittonEKolbB (2001). Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex.Synapse39, 257–266.
200.
RobinsonTEKolbB (1999). Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine.European Journal of Neuroscience11, 1598–1604.
201.
RochaBAMeadANKosofskyBE (2002). Increased vulnerability to self-administer cocaine in mice prentally exposed to cocaine.Psychopharmacology163, 221–229.
202.
RockmanGEHallAMMarkertLEGlavinGB (1988). Influence of rearing conditions on voluntary ethanol intake and response to stress in rats.Behavioral and Neural Biology49, 184–191.
203.
RogersRDEverittBJBaldacchinoAJohnsonAJSwainsonRLondonM (1999). et al. Dissociable deficits in decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: Evidence for monoaminergic mechanisms.Neuropsychopharmacology20, 322–339.
204.
RossettiYCarboniEStancampianoRSoriPPepeuGFaddaF (2002). Bidirectional modulation of spatial working memory by ethanol.Alcoholism: Clinical and Experimental Research26, 181–185.
205.
RudnickGWallSC (1992). The molecular mechanism of “ecstasy” [3,4 methylenediosymethamphetamine (MDMA)]: Serotonin transporters are targets for MDMA-induced serotonin release.Proceedings of the National Academy of Sciences (USA)89, 1817–1821.
206.
RuotsalainenSMiettinenRMacDonaldEKoivistoESirvioJ (2000). Blockade of muscarinic, rather than nicotinic, receptors impairs attention, but does not interact with serotonin depletion.Psychopharmacology148, 111–123.
207.
RyanLJLinderJCMartoneMEGrovesPM (1990). Histological and ultrastructural evidence that d-amphetamine causes degeneration in neostriatum and frontal cortex of rats.Brain Research518, 67–77.
208.
SabolKERichardsJLaytonKSeidenL (1995). Amphetamine analogs have differential effects on DRL 36-s schedule performance.Psychopharmacology121, 57–65.
209.
SahakianBJRobbinsTWMorganMJIversenSD (1975). The effects of psychomotor stimulants on stereotypy and the locomotor activity in socially deprived and control rats.Brain Research84, 195–205.
210.
SalvatoreMFHudspethOArnoldLEWilsonPEStanfordJAMactutusCF (2004). et al. Prenatal cocaine exposure alters potassium-evoked dopamine release dynamics in rat striatum.Neuroscience123, 481–490.
211.
SchenkSGormanKAmitZ (1990). Age-dependent effects of isolation housing on the self-administration of ethanol in laboratory rats.Alcohol7, 321–326.
212.
SchenkSLacelleGFormanKAmitZ (1987). Cocaine self-administration in rats influenced by environmental conditions: Implications for the etiology of drug abuse.Neuroscience Letters81, 227–231.
213.
SchenkSRobinsonBAmitZ (1988). Housing conditions fail to affect the intravenous self-administration of amphetamine.Pharmacology, Biochemistry and Behavior31, 59–62.
214.
SchrijverNCAWurbelH (2001). Early social deprivation disrupts attentional, but not affective, shifts in rats.Behavioral Neuroscience115, 437–442.
215.
SchwartzASMarchokPL (1974). Depression of morphine-seeking behaviour by dopamine inhibition.Nature248, 257–258.
SegalDSKuczenskiR (1997a). Behavioral alterations induced by an escalating dose-binge pattern of cocaine administration.Behavioural Brain Research88, 251–260.
218.
SegalDSKuczenskiR (1997b). Repeated binge exposures to amphetamine and methamphetamine: Behavioral and neurochemical characterization.Journal of Pharmacology and Experimental Therapeutics282, 561–573.
219.
SegalDSKuczenskiR (1999). Escalating dose-binge stimulant exposure: Relationship between emergent behavioral profile and differential caudate-putamen and nucleus accumbens dopamine responses.Psychopharmacology142, 182–192.
220.
ShahamYErbSStewartJ (2000). Stress-induced relapse to heroin and cocaine seeking in rats: A review.Brain Research Reviews1.
221.
ShenRYHanniganJHKapatosG (1999). Prenatal ethanol exposure reduces the activity of adult midbrain dopamine neurons.Alcoholism: Clinical and Experimental Research23, 1801–1807.
222.
SingerLTMinnesSShortEArendtRFarkasKLewisG (2004). et al. Cognitive outcomes of preschool children with prenatal cocaine exposure.Journal of the American Medical Association291, 2448–2456.
223.
SmithAMFriedPAHoganMJCameronI (2004). Effects of prenatal marijuana on response inhibition: An fMRI study of young adults.Neurotoxicology and Teratology26, 533–542.
224.
SmithRF (2003). Animal models of periadolescent substance abuse.Neurotoxicology and Teratology25, 291–301.
225.
SokolowskiJDSalamoneJD (1994). Effects of dopamine depletions in the medial prefrontal cortex on DRL performance and motor activity in the rat.Brain Research642, 20–28.
226.
SowellERThompsonPMTessnerKDTogaAW (2001). Mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: Inverse relationships during postadolescent brain maturation.Journal of Neuroscience21, 8819–8829.
227.
SpearLPBrakeSC (1983). Periadolescence: Age-dependent behavior and psychopharmacological responsivity in rats.Developmental Pyschobiology16, 83–109.
228.
StapletonJMMorganMJPhillipsRLWongDFYungBCKShayaEK (1995). et al. Cerebral glucose utilization in polysubstance abuse.Neuropsychopharmacology13, 22–31.
StewartJBadianiA (1993). Tolerance and sensitization to the behavioral effects of drugs.Behavioural Pharmacology4, 289–312.
231.
StreissguthAPMartinDCBarrHMMacGregor-SandmanB (1984). Intrauterine alcohol and nicotine exposure: Attention and reaction time in 4-year-old children.Developmental Psychology20, 533–541.
232.
SzechtmanHEckertMJTseWSBoersmaJTBonuraCAMcClellandJZ (2001). et al. Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive–Compulsive Disorder (OCD): Form and control.Biomedical Central: Neuroscience2, 1471–2202.
233.
SzechtmanHWoodyE (2003). Obsessive–Compulsive Disorder as a disturbance of security motivation.Psychological ReviewX, 1–28.
234.
TaylorJRJentschJD (2001). Repeated intermittent administration of psychomotor stimulant drugs alters the acquisition of Pavlovian approach behavior in rats: Differential effects of cocaine, d-amphetamine and 3,4- methylenedioxymethamphetamine (“Ecstasy”).Biological Psychiatry50, 137–143.
235.
TiffanyST (1990). A cognitive model of drug urges and drug-use behavior: Role of automatic and nonautomatic processes.Psychological Review97, 147–168.
236.
TornatzkyWMiczekKA (1999). Repeated limited access to IV cocaine self-administration: Conditioned autonomic rhythmicity illustrating “predictive homeostasis”.Psychopharmacology145, 144–152.
237.
TornatzkyWMiczekKA (2000). Cocaine self-administration “binges”: transition from behavioral and automatic regulation toward homeostatic dysregulation in rats.Psychopharmacology148, 289–298.
238.
UnterwaldEMHoARubenfieldJMKreekMJ (1994). Time course of the development of behavioral sensitization and dopamine receptor up-regulation during binge cocaine administration.Journal of Pharmacology and Experimental Therapeutics270, 1387–1397.
239.
VanderschurenLJMJEverittBJ (2004). Drug seeking becomes compulsive after prolonged cocaine self-administration.Science305, 1017–1019.
240.
VolkowNDFowlerJS (2000). Addiction, a disease of compulsion and drive: Involvement of the orbitofrontal cortex.Cerebral Cortex10, 318–325.
241.
von KnorringLvon KnorringASmiganLLindbergUEdholmM (1987). Personality traits in subtypes of alcoholics.Journal of Studies on Alcohol48, 523–527.
242.
VuchinichRESimpsonCA (1998). Hyperbolic temporal discounting in social drinkers and problem drinkers.Experimental and Clinical Psychopharmacology6, 292–305.
243.
WadeTRde WitHRichardsJB (2000). Effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats.Psychopharmacology150, 90–101.
244.
WeissenbornRRobbinsTWEverittBJ (1997). Effects of medial prefrontal or anterior cingulate cortex lesions on responding for cocaine under fixed-ratio and second-order schedules of reinforcement in rats.Psychopharmacology134, 242–257.
245.
WengerGWrightD (1990). Behavioral effects of cocaine and its interactions with D-amphetamine and morphine in rats.Pharmacology, Biochemistry and Behavior35, 595–600.
246.
WhiteAMGhiaAJLevinEDSwartzwelderHS (2000). Binge pattern ethanol exposure in adolescent and adult rats: Differential impact on subsequent responsiveness to ethanol.Alcoholism: Clinical and Experimental Research24, 1251–1256.
247.
WhiteNM (1996). Addictive drugs as reinforcers: Multiple partial actions on memory systems.Addiction91, 921–949.
248.
WilcottRC (1982). Frontal lesions and the rate of operant behavior.Physiological Psychology10, 371–375.
249.
WilliamsBRPonesseJSSchacharRJLoganGDTannockR (1999). Development of inhibitory control across the life span.Developmental Psychology35, 205–213.
250.
WilmouthCESpearLP (2004). Adolescent and adult rats' aversion to flavors previously paired with nicotine.Annals New York Academy of Sciences1021, 462–464.
251.
WilsonJMNobregaJNCorrigallWACoenKMShannakKKishSJ (1994). Amygdala dopamine levels are markedly elevated after self- but not passive-administration of cocaine.Brain Research668, 39–45.
252.
WiseRA (1988). The neurobiology of craving: Implications for the understanding and treatment of addiction.Journal of Abnormal Psychology97, 118–132.
253.
WiseRA (1996). Neurobiology of addiction.Current Opinion in Neurobiology6, 243–251.
254.
WiseRA (1999). Cognitive factors in addiction and nucleus accumbens function: Some hints from rodent models.Psychobiology27, 300–310.
255.
WiseRA (2000). Addiction becomes a brain disease.Neuron26, 27–33.
256.
WiseRABozarthMA (1987). A psychomotor stimulant theory of addiction.Psychological Review94, 469–492.
257.
WoolvertonWLKandelDBSchusterCR (1978). Effects of repeated administration of cocaine on schedule-controlled behavior of rats.Pharmacology, Biochemistry and Behavior9, 327–337.
258.
YinHHKnowltonBJBalleineBW (2004). Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning.European Journal of Neuroscience19, 181–189.
259.
ZhangYSchlussmanSDHoAKreekMJ (2001). Effect of acute binge cocaine on levels of extracellular dopamine in the caudate putamen and nucleus accumbens in male C57BL/6J and 129/J mice.Brain Research923, 172–177.
