Bare and functionalised haematite nanoparticles (NPs) are synthesised through the co-precipitation method and characterised using XRD, SEM, TEM, EDX, FTIR, and VSM. XRD confirmed the rhombohedral-based hexagonal structure of Fe2O3, while, TEM and SEM showed the formation of lamellar-shaped NPs with the grain size varied from 22 to 80 nm. VSM presented soft ferromagnetic behaviour. From in vivo evaluations, changes in serum levels are analysed at different days of study after administration of bare and coated NPs through the intraperitoneal route of administration in albino rats. Toxicity parameters revealed a transient increase at day 1 but a gradual decrease thereafter. For biodegradation studies, NPs exposure in lysosomal-like medium showed insignificant changes in the absorbance spectrum for a short interval of time, however, dynamical degradation effects were observed on Day 8. Apoferritin studies disclose the growth of absorbance near 260 nm, which reveals progressive and partially filled proteins with iron ions.
CurcioA, MarottaR, RiedingerA, Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs). Chem Commun. 2012;48(18):2400–2402.
2.
HachaniR, BirchallMA, LowdellMW, Assessing cell-nanoparticle interactions by high content imaging of biocompatible iron oxide nanoparticles as potential contrast agents for magnetic resonance imaging. Sci Rep. 2017;7(1):1–14.
3.
CortajarenaAL, OrtegaD, OcampoSM, Engineering iron oxide nanoparticles for clinical settings. Nanobiomedicine (Rij). 2014;1(Godište 2014):1–2.
4.
BarrowM, TaylorA, MurrayP, Design considerations for the synthesis of polymer coated iron oxide nanoparticles for stem cell labelling and tracking using MRI. Chem Soc Rev. 2015;44(19):6733–6748.
5.
VangijzegemT, StanickiD, LaurentS.Magnetic iron oxide nanoparticles for drug delivery: applications and characteristics. Expert Opin Drug Deliv. 2019;16(1):69–78.
6.
AbenojarEC, WickramasingheS, Bas-ConcepcionJ, Structural effects on the magnetic hyperthermia properties of iron oxide nanoparticles. Prog Nat Sci: Mater Int. 2016;26(5):440–448.
7.
LinR, LiY, MacDonaldT, Improving sensitivity and specificity of capturing and detecting targeted cancer cells with anti-biofouling polymer coated magnetic iron oxide nanoparticles. Colloids Surf B. 2017;150:261–270.
8.
SoenenSJ, HimmelreichU, NuyttenN, Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling. Biomater. 2011;32(1):195–205.
9.
BarrowM, TaylorA, Fuentes-CaparrósAM, SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?Biomater Sci. 2018;6(1):101–106.
10.
XieJ, LiuG, EdenHS, Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy. Acc Chem Res. 2011;44(10):883–892.
11.
GaoJ, GuH, XuB.Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. Acc Chem Res. 2009;42(8):1097–1107.
LiuG, GaoJ, AiH, Applications and potential toxicity of magnetic iron oxide nanoparticles. Small. 2013;9(9-10):1533–1545.
14.
NosratiH, SalehiabarM, ManjiliHK, Preparation of magnetic albumin nanoparticles via a simple and one-pot desolvation and co-precipitation method for medical and pharmaceutical applications. Int J Biol Macromol. 2018;108:909–915.
15.
ErdoganS, ZerenEH, EmreM, Pulmonary effects of deltamethrin inhalation: an experimental study in rats. Ecotoxicol Environ Saf. 2006;63(2):318–323.
16.
DarbandiM, StrombergF, LandersJ, Nanoscale size effect on surface spin canting in iron oxide nanoparticles synthesized by the microemulsion method. J Phys D: Appl Phys. 2012;45(19):1–11.
17.
DavarF, HadadzadehH, AlaediniTS.Single-phase hematite nanoparticles: Non-alkoxide sol–gel based preparation, modification and characterization. Ceram Int. 2016;42(16):19336–19342.
18.
MargabandhuM, SendhilnathanS, MaragathavalliS, Synthesis characterization and antibacterial activity of iron oxide nanoparticles. Glob. J. Bio Sci. Biotechnol. 2015;4:335–341.
19.
BhavaniP, RajababuC, ArifM, Synthesis of high saturation magnetic iron oxide nanomaterials via low temperature hydrothermal method. J Magn Magn Mater. 2017;426:459–466.
20.
KurniawanG, KhumaeniA.Synthesis of iron oxide nanoparticle using pulsed laser ablation method at low laser energy). AIP conference proceedings. 2018: AIP Publishing LLC.
21.
HachaniR, LowdellM, BirchallM, Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents. Nanoscale. 2016;8(6):3278–3287.
22.
Kolosnjaj-TabiJ, LartigueL, JavedY, Biotransformations of magnetic nanoparticles in the body. Nano Today. 2016;11(3):280–284.
23.
LartigueL, AlloyeauD, Kolosnjaj-TabiJ, Biodegradation of iron oxide nanocubes: high-resolution in situ monitoring. Acs Nano. 2013;7(5):3939–3952.
24.
MosaiabT, JeongCJ, ShinGJ, Recyclable and stable silver deposited magnetic nanoparticles with poly (vinyl pyrrolidone)-catechol coated iron oxide for antimicrobial activity. Mater Sci Eng: C. 2013;33(7):3786–3794.
25.
SinghRP, RamaraoP.Cellular uptake, intracellular trafficking and cytotoxicity of silver nanoparticles. Toxicol Lett. 2012;213(2):249–259.
26.
ChoW-S, DuffinR, HowieSE, Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn 2+ dissolution inside lysosomes. Part Fibre Toxicol. 2011;8(1):1–16.
27.
LiuN, MuY, ChenY, Degradation of aqueous synthesized CdTe/ZnS quantum dots in mice: differential blood kinetics and biodistribution of cadmium and tellurium. Part Fibre Toxicol. 2013;10(1):1–9.
28.
VolatronJ, Kolosnjaj-TabiJ, JavedY, Physiological remediation of cobalt ferrite nanoparticles by ferritin. Sci Rep. 2017;7(1):1–10.
29.
LevyM, LucianiN, AlloyeauD, Long term in vivo biotransformation of iron oxide nanoparticles. Biomater. 2011;32(16):3988–3999.
30.
AkhtarK, JavedY, JamilY, Functionalized cobalt ferrite cubes: toxicity, interactions and mineralization into ferritin proteins. Appl Nanosci. 2020;10(9):3659–3674.
31.
VolatronJ, CarnF, Kolosnjaj-TabiJ, Ferritin protein regulates the degradation of iron oxide nanoparticles. Small. 2017;13(2):1–13.
32.
HoskinsC, WangL, ChengWP, Dilemmas in the reliable estimation of the in-vitro cell viability in magnetic nanoparticle engineering: which tests and what protocols?Nanoscale Res Lett. 2012;7(1):1–12.
33.
LiL, MakK, LeungC, Effect of synthesis conditions on the properties of citric-acid coated iron oxide nanoparticles. Microelectron Eng. 2013;110:329–334.
34.
EzzaierH, MarinsJ, ClaudetC, Kinetics of aggregation and magnetic separation of multicore iron oxide nanoparticles: effect of the grafted layer thickness. Nanomaterials. 2018;8(8):1–29.
35.
AdegokeHI, AmooAdekolaF, FatokiOS, Adsorption of Cr (VI) on synthetic hematite (α-Fe 2 O 3) nanoparticles of different morphologies. Korean J Chem Eng. 2014;31(1):142–154.
36.
TadicM, TrpkovD, KopanjaL, Hydrothermal synthesis of hematite (α-Fe2O3) nanoparticle forms: synthesis conditions, structure, particle shape analysis, cytotoxicity and magnetic properties. J Alloys Compd. 2019;792:599–609.
37.
HillA, JiaoF, BruceP, Neutron diffraction study of mesoporous and bulk hematite, α-Fe2O3. Chem Mater. 2008;20(15):4891–4899.
38.
WahabA, ImranM, IkramM, Dye degradation property of cobalt and manganese doped iron oxide nanoparticles. Appl Nanosci. 2019;9(8):1823–1832.
39.
NadeemM, AhmadM, AkhtarMS, Magnetic properties of polyvinyl alcohol and doxorubicine loaded iron oxide nanoparticles for anticancer drug delivery applications. PloS One. 2016;11(6):1–12.
40.
Miguel-SanchoN, Bomatí-MiguelO, ColomG, Development of stable, water-dispersible, and biofunctionalizable superparamagnetic iron oxide nanoparticles. Chem Mater. 2011;23(11):2795–2802.
41.
ZhangB, TuZ, ZhaoF, Superparamagnetic iron oxide nanoparticles prepared by using an improved polyol method. Appl Surf Sci. 2013;266:375–379.
42.
AkhtarK, JavedY, MuhammadF, Biotransformation and toxicity evaluation of functionalized manganese doped iron oxide nanoparticles. J Biomed Mater Res Part B: Appl Biomater. 2021.
43.
RezaeiZS.Effect of Titanium Dioxide Nanoparticles on the Amount of Blood Cells and Liver Enzymes in Wistar. Rats. SSU Journals. 2011;19(5):618–626.
44.
AhamedM, AlSalhiMS, SiddiquiM.Silver nanoparticle applications and human health. Clin Chim Acta. 2010;411(23–24):1841–1848.
45.
GuoM, XuX, YanX, In vivo biodistribution and synergistic toxicity of silica nanoparticles and cadmium chloride in mice. J Hazard Mater. 2013;260:780–788.
46.
ArbabAS, WilsonLB, AshariP, A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging. NMR Biomed. 2005;18(6):383–389.
47.
LianJ, DuanX, MaJ, Hematite (α-Fe2O3) with various morphologies: ionic liquid-assisted synthesis, formation mechanism, and properties. ACS Nano. 2009;3(11):3749–3761.
48.
SorescuM, BrandR, Mihaila-TarabasanuD, The crucial role of particle morphology in the magnetic properties of haematite. J Appl Phys. 1999;85(8):5546–5548.
