Controlled prescription drug (CPD) abuse is an increasing threat to patient safety and health care providers (HCPs) are not adequately prepared nor do they routinely employ proper screening techniques. Using standardized patients (SPs) as an instructional strategy, the trained physicians on proper prescribing practices and SBIRT (Screening, Brief Intervention, and Referral to Treatment) in a continuing medical education (CME) course. The authors compared two physician cohorts receiving standard CME course (control) versus CME plus SP practice. They measured knowledge and attitudes in all participants and skills and perceived competence in the SP group only. Knowledge and attitudes improved significantly for both groups. Screening behaviors for CPD use also improved. Participants overestimated their performance but increased their use of SBIRT with practice. The SP comfort levels with physician's competence improved after 2 practice sessions. Standardized patients can be an effective teaching tool in CME courses. Impact on knowledge or attitudes did not increase significantly over controls.