Abstract
Purpose, Material and Methods, and Results: The dialyzability of the high-molecular X-ray contrast medium iodixanol was examined in an in vitro hemo-dialysis model using two different hollow fiber membranes: one high-flux (polysulfone) membrane and one intermediate-flux (cellulose triacetate) membrane. Blood flow was 200 ml/min and membrane area 1.3 m2. The dialyzer clearance of iodixanol dissolved in a mixture of leukocyte-filtered SAG-M blood and compatible citrate plasma was 134.2±3.6 ml/min for the polysulfone membrane and 113.0±3.6 ml/min for the cellulose triacetate membrane.
Conclusion: Iodixanol is readily dialyzed through commercial high-flux membranes.
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