Magnesium (Mg) and its biocompatible alloys are used as biodegradable materials for temporary implant applications. However, the fast electrochemical reactions in the physiological environment can lead to premature implant failure and damage the surrounding tissues. Here, we report on nanoparticle-modified biopolymer composite coatings processed using alternating current electrophoretic deposition (AC-EPD) to control the corrosion process of Mg–Al alloys. Chitosan–gelatin coatings incorporating bioactive glass particles as reinforcement were supplemented with ZnO and CeO2 nanoparticles and the corrosion resistance was evaluated. CeO2 nanoparticle-modified coatings obtained using AC signals superimposed with a direct current field appeared compact and homogeneous. ZnO nanoparticle-modified coatings had a low surface coverage with significant defects. As a result, CeO2-supplemented coatings processed for as little as 4 min effectively reduced the corrosion current density (icorr) of Mg–Al in Ringer's solution, whereas ZnO-supplemented coatings did not. CeO2 nanoparticle-modified biopolymer coatings hold potential for fine-tuning the degradation of Mg implants.
AlbrektssonT, BrånemarkPI, HanssonHA, Osseointegrated titanium implants: requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52:155–170.
2.
DingW.Opportunities and challenges for the biodegradable magnesium alloys as next-generation biomaterials. Regen Biomater. 2016;3(2):79–86.
3.
CharyevaO, DakischewO, SommerU, Biocompatibility of magnesium implants in primary human reaming debris-derived cells stem cells in vitro. J Orthop Trauma. 2016;17(1):63–73.
4.
BurmesterA, Willumeit-RömerR, FeyerabendF.Behavior of bone cells in contact with magnesium implant material. J Biomed Mater Res Part B Appl Biomater. 2017;105(1):165–179.
5.
WangP, HuSS, ShenJQ, Microstructure and mechanical behaviour of cold metal transfer welded Mg/Al dissimilar joint using wire AZ31 as filler metal. Sci Technol Weld Join. 2017;22(4):353–361.
6.
ShengK, LuLW, XiangY, Microstructure and mechanical properties of AZ31 Mg alloy fabricated by pre-compression and frustum shearing extrusion. Acta Metall Sin-Eng. 2019;32(2):235–244.
7.
DziubińskaA, GontarzA, HorzelskaK, The microstructure and mechanical properties of AZ31 magnesium alloy aircraft brackets produced by a new forging technology. Procedia Manuf. 2015;2:337–341.
8.
ZengR, DietzelW, WitteF, Progress and challenge for magnesium alloys as biomaterials. Adv Eng Mater. 2008;10:B3–B14.
9.
KumarK, GillRS, BatraU.Challenges and opportunities for biodegradable magnesium alloy implants. Mater Technol. 2018;33(2):153–172.
10.
LiuF, JiY, SunZ, Enhancing corrosion resistance of Al-Cu/AZ31 composites synthesized by a laser cladding and FSP hybrid method. Mater Manuf Process. 2019;34(13):1458–1466.
11.
SongG, SongSZ.A possible biodegradable magnesium implant material. Adv Eng Mater. 2007;9:298–302.
12.
BrarHS, PlattMO, SarntinoranontM, Magnesium as a biodegradable and bioabsorbable material for medical implants. JOM. 2009;61:31–34.
13.
HarandiSE, RamanRS.Appropriate mechanochemical conditions for corrosion-fatigue testing of magnesium alloys for temporary bioimplant applications. JOM. 2015;67:1137–1142.
14.
SanthanakrishnanS, HoY, DahotreN.Laser coating of hydroxyapatite on Mg for enhanced physiological corrosion resistance and biodegradability. Mater Technol. 2012;27:273–277.
15.
SoleymaniF, EmadiR, SadeghzadeS, Applying baghdadite/PCL/chitosan nanocomposite coating on AZ91 magnesium alloy to improve corrosion behavior, bioactivity, and biodegradability. Coatings. 2019;9(12):789.
16.
BatoolSA, WadoodA, HussainSW, A brief insight to the electrophoretic deposition of PEEK-, chitosan-, gelatin-, and zein-based composite coatings for biomedical applications: recent developments and challenges. Surfaces. 2021;4(3):205–239.
17.
AkramM, ArshadN, AktanMK, Alternating current electrophoretic deposition of chitosan–gelatin–bioactive glass on Mg–Si–Sr alloy for corrosion protection. ACS Appl Bio Mater. 2020;3(10):7052–7060.
18.
Ur RehmanMA, BastanFE, NawazQ, Electrophoretic deposition of lawsone loaded bioactive glass (BG)/chitosan composite on polyetheretherketone (PEEK)/BG layers as antibacterial and bioactive coating. J Biomed Mater Res A. 2018;106:3111–3122.
19.
QiH, HeiseS, ZhouJ, Electrophoretic deposition of bioadaptive drug delivery coatings on magnesium alloy for bone repair. ACS Appl Mater Interfaces. 2019;11:8625–8634.
20.
JiangT, ZhangZ, ZhouY, Surface functionalization of titanium with chitosan/gelatin via electrophoretic deposition: characterization and cell behavior. Biomacromolecules. 2010;11:1254–1260.
21.
DiezM, KangMH, KimSM, Hydroxyapatite (HA)/poly-L-lactic acid (PLLA) dual coating on magnesium alloy under deformation for biomedical applications. J Mater Sci Mater Med. 2016;27:34.
22.
SeussS, BoccacciniAR.Electrophoretic deposition of biological macromolecules, drugs, and cells. Biomacromolecules. 2013;14:3355–3369.
23.
BraemA, De BruckerK, DelattinN, Alternating current electrophoretic deposition for the immobilization of antimicrobial agents on titanium implant surfaces. ACS Appl Mater Interfaces. 2017;9(10):8533–8546.
24.
MartăuGA, MihaiM, VodnarDC.The use of chitosan, alginate, and pectin in the biomedical and food sector – biocompatibility, bioadhesiveness, and biodegradability. Polymers (Basel). 2019;11(11):1837.
25.
EnescuD, OlteanuCE.Functionalized chitosan and its use in pharmaceutical, biomedical, and biotechnological research. Chem Eng Commun. 2008;195(10):1269–1291.
26.
SellSE, WolfePS, GargK, The use of natural polymers in tissue engineering: a focus on electrospun extracellular matrix analogues. Polymers (Basel). 2010;2(4):522–553.
27.
ChionoV, PulieriE, VozziG, Genipin-crosslinked chitosan/gelatin blends for biomedical applications. J Mater Sci Med. 2008;19(2):889–898.
28.
BenbettaïebN, KurekM, BornazS, Barrier, structural and mechanical properties of bovine gelatin–chitosan blend films related to biopolymer interactions. J Sci Food Agr. 2014;94(12):2409–2419.
29.
NathanaelAJ, OhTH.Biopolymer coatings for biomedical applications. Polymers (Basel). 2020;12(12):3061.
30.
HajialiF, TajbakhshS, ShojaeiA.Fabrication and properties of polycaprolactone composites containing calcium phosphate-based ceramics and bioactive glasses in bone tissue engineering: a review. Polym Rev. 2018;58(1):164–207.
31.
MajiK.Biomaterials for bone tissue engineering: recent advances and challenges. In: LiB, WebsterT, editors. Orthopedic Biomaterials.Springer, Cham; 2018.
32.
Bakhsheshi-RadHR, HamzahE, IsmailAF, In vitro corrosion behavior, bioactivity, and antibacterial performance of the silver-doped zinc oxide coating on magnesium alloy. Mater Corros. 2017;68(11):1228–1236.
33.
CaladoLM, TarybaMG, CarmezimMJ, Self-healing ceria-modified coating for corrosion protection of AZ31 magnesium alloy. Corros Sci. 2018;142:12–21.
34.
MatterMT, FurerLA, StarsichFH, Engineering the bioactivity of flame-made ceria and ceria/bioglass hybrid nanoparticles. ACS Appl Mater Interfaces. 2018;11(3):2830–2839.
35.
BraemA, MattheysT, NeirinckB, Bioactive glass–ceramic coated titanium implants prepared by electrophoretic deposition. Mater Sci Eng C. 2012;32(8):2267–2273.
36.
DrnovšekN, NovakS, DraginU, Bioactive glass enhances bone ingrowth into the porous titanium coating on orthopaedic implants. Inter Orthop. 2012;36(8):1739–1745.
37.
SuoL, JiangN, WangY, The enhancement of osseointegration using a graphene oxide/chitosan/hydroxyapatite composite coating on titanium fabricated by electrophoretic deposition. J Biomed Mater Res Part B Appl Biomater. 2019;107(3):635–645.
38.
Al-Shuja'aO, ObeidA, El-ShekeilY, New strategy for chemically attachment of imine group on multi-walled carbon nanotubes surfaces: synthesis, characterization and study of dc electrical conductivity. J Mater Sci Chem Eng. 2017;5(2):11–21.
39.
SongJ, CuiX, JinG, Self-healing conversion coating with gelatin–chitosan microcapsules containing inhibitor on AZ91D alloy. Surf Eng. 2018;34(1):79–84.
40.
GritschL, LovellC, GoldmannWH, Fabrication and characterization of copper (II)-chitosan complexes as antibiotic-free antibacterial biomaterial. Carbohydr Polym. 2018;179:370–378.
41.
Persaud-SharmaD, McGoronA.Biodegradable magnesium alloys: a review of material development and applications. J Biomim Biomater Tissue Eng. 2011;12:25–39.
42.
HahnBD, ParkDS, ChoiJJ, Aerosol deposition of hydroxyapatite–chitosan composite coatings on biodegradable magnesium alloy. Surf Coat Tech. 2011;205(8–9):3112–3118.
43.
WangaC, JiangB, LiuM, Corrosion characterization of micro-arc oxidization composite electrophoretic coating on AZ31B magnesium alloy. J Alloys Compd. 2015;621:53–61.
44.
JiaZ, XiongP, ShiY, Inhibitor encapsulated, self-healable and cytocompatible chitosan multilayer coating on biodegradable Mg alloy: a pH-responsive design. J Mater Chem B. 2016;4(14):2498–2511.
45.
FajardieF, ManoliJM, Djega-MariadassouG, Ceria lattice oxygen ion substitution by Cl− during the reduction of Rh(Cl)/CeO2 catalysts. formation and stability of CeOCl. J Chem Soc Faraday Trans. 1998;94(24):3727–3735.
46.
MullinsDR, AlbrechtPM, ChenTL, Water dissociation on CeO2(100) and CeO2(111) thin films. J Phys Chem C. 2012;116:19419–19428.
47.
Fernández-TorreD, KośmiderK, CarrascoJ, Insight into the adsorption of water on the clean CeO2(111) surface with van der Waals and hybrid density functionals. J Phys Chem C. 2012;116:13584–13593.
48.
AramakiK.A self-healing protective film prepared on zinc by treatment in a Ce(NO3)3 solution and modification with Ce(NO3)3. Corros Sci. 2005;47(5):1285–1298.
