The effects of the structure of di- and triblock copolymers of poly(L-lysine) – LYS with poly(ethylene glycol) – PEG as well as the length of nonionic fragment in the LYS-PEG macromolecule on the copolymer chains conformation in the adsorption layer formed on the colloidal silica (SiO2) surface were examined. Spectrophotometry and turbidimetry were applied for the determination of copolymer adsorbed amounts and stability coefficients of silica aqueous suspensions. The electrokinetic parameters such as solid surface charge density and zeta potential were also estimated. The adsorption of LYS-PEG was proved to be the highest at pH 10 whereas the lowest adsorption on the solid surface was found for the triblock copolymer with long fragments of LYS at the same pH value.
MorellM, PuiggaliJ.Hybrid block copolymers constituted by peptides and synthetic polymers: an overview of synthetic approaches, supramolecular behavior and potential applications. Polymer. 2013;5:188–224. doi: 10.3390/polym5010188
2.
YuanM, DengX.Synthesis and characterization of poly (ethylene glycol)-block-poly(amino acid) copolymer. Europ Polym J. 2001;37:1907–1912. doi: 10.1016/S0014-3057(01)00042-8
WangXQ, ZhangQ.Ph – sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water – soluble drugs. Europ J Pharmac Biopharmac. 2012;82:219–229. doi: 10.1016/j.ejpb.2012.07.014
10.
LuY, ParkK.Polymeric micelles and alternative nanosized delivery vehicles for poorly soluble drugs. Int J Pharm. 2013;453:198–214. doi: 10.1016/j.ijpharm.2012.08.042
11.
OstolskaI, WiśniewskaM, Nosal-WiercińskaA, Adsorption layer structure in the system of the ionic block polyamino acid copolymers/SiO2 particles. Colloids Surf A. 2016;488:138–144. doi: 10.1016/j.colsurfa.2015.10.025
12.
LiuG, MolasM, GrossmannGA, Biological properties of poly-l-lysine-DNA complexes generated by cooperative binding of the polycation *210. J Biol Chem. 2001;276:34379–34387. doi: 10.1074/jbc.M105250200
13.
LamJ, ClarkEC, FongEL, Evaluation of cell-laden polyelectrolyte hydrogels incorporating poly(L-Lysine) for applications in cartilage tissue engineering. Biomaterials. 2016;83:332–346. doi: 10.1016/j.biomaterials.2016.01.020
14.
OstolskaI, WiśniewskaM.Comparison of the influence of polyaspartic acid and polylysine functional groups on the mechanism of polymeric film formation at the Cr2O3-aqueous solution interface. Appl Surf Sci. 2014;311:734–739. doi: 10.1016/j.apsusc.2014.05.149
15.
TerpiłowskiK, WiśniewskaM, ZarkoV.Influence of solution pH, supporting electrolyte presence and solid content on the stability of aqueous nanosilica suspension. J Ind Eng Chem. 2015;30:71–76. doi: 10.1016/j.jiec.2015.05.003
16.
JanuszW.Electrical double layer at the metal oxide/electrolyte interface in interfacial forces and fields: theory and applications. In: DeckerM, editor. Surfactant Science. Vol. 85. New York: Marcel Dekker, Inc; 1994; chapter 4.
17.
HunterRJ.Zeta potential in colloid science. New York ( NY): Academic Press; 1981.
18.
DerosaRL, TrapassoJA.Poly(ethylene glycol) interactions with alumina and silica powders determined via DRIFT. J Mater Sci. 2002;37:1079–1082. doi: 10.1023/A:1014328716329
19.
OstolskaI, WiśniewskaM.Application of the zeta potential measurements to explanation of colloidal Cr2O3 stability mechanism in the presence of the ionic polyamino acids. Colloid Polym Sci. 2014;292:2453–2464. doi: 10.1007/s00396-014-3276-y
20.
HangJ, ShiL, FengX, Electrostatic and electrosteric stabilization of aqueous suspensions of barite nanoparticles. Powder Technol. 2009;192:166–170. doi: 10.1016/j.powtec.2008.12.010
21.
ShinY, RobertsJE, SantoreMM.The relationship between polymer/substrate charge density and charge overcompensation by adsorbed polyelectrolyte layers. J Colloid Interf Sci. 2002;247:220–230. doi: 10.1006/jcis.2001.8100
