Se presenta en este artículo una introducción al campo de estudio de las relaciones entre factores psicosociales y neoplasia, enmarcándolo dentro de la medicina conductual y desde un enfoque interdisciplinar. A continuación se discute el papel que pueden desempeñar las variables psicosociales (estrés) en la vulnerabilidad del ser humano a la enfermedad en general a través de su acción sobre el sistema inmune. En el apartado III se realiza una revisión crítica en la investigación en la que se ha intentado delimitar la influencia de factores psicosociales en la aparición y pronóstico del cáncer, en animales (cáncer experimental) y en el ser humano. Se discute por último el papel de los mediadores biológicos propuestos como más importantes hasta el momento en la literatura del área (sistemas neuroendocrino e inmune). De esta revisión se desprende que los resultados de la investigación, aunque su- gerentes no son definitivos, ni tampoco están claros los mecanismos biológicos a través de los cuales se puede producir la influencia. Después de analizar algunas de las deficiencias metodológicas más importantes de los trabajos realizados, creemos que en enfoque más adecuado para poner a prueba la hipótesis de que los factores psicosociales afectan al desarrollo del cáncer debería ser longitudinal, utilizando grandes muestras y estudiando variables psicosociales y biomédicas conjuntamente.
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