Session 9: Cancer Therapy

Okamura, H. , Tsutsui, H. , Kashiwamura, S. , Yoshimoto, T. , and Nakanishi, K. (1998). Interleukin-18: a novel cytokine that augments both innate and acquired immunity. Adv Immunol 70, 281—312.

Jonak, Z.L. , Trulli, S. , Maier, C. , McCabe, F. , Kirkpatrick, R. , Johanson, K. , Ho, Y.S. , Chen, Y.J. , Herzyk, D. , Lotze, M.T. , and Johnson, R.K. (2002.) High-dose rInterleukin-18 induces an effective Th1 immune response to murine MOPC-315 plasmacytoma. Journal of Immunotherapy 25(Suppl 1), S20—7.

Nakanishi, K. , Yoshimoto, Y. , Tsutsui, H. , and Okamura, H. (2001). Interleukin-18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol. 19, 423—74.

Akira, S. (2000). The role of IL-18 in innate immunity. Current Opinion in Immunol. 12, 59—63.

Kreitman, R.J. , Wilson, W.H. , Bergeron, K. , Raggio, M. , Stetler-Stevenson , M. , FitzGerald, D.J. , and Pastan, I. (2001). Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant Hairy cell leukemia. N Engl J Med 345, 241—7.

Salvatore, G. , Beers, R. , Margulies, I. , Kreitman, R.J. , and Pastan, I. (2002). Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phase display. Clin Cancer Res 8, 995—1002.

Chowdhury, P.S. , and Pastan, I. (1999). Improving antibody affinity by mimicking somatic hypermutation in vitro. Nature Biotech . 17, 568—72.

Kreitman, R.J. , Margulies, I. , Stetler-Stevenson , M. , Wang, Q.C. , FitzGerald, D.J.P. , and Pastan, I. (2000). Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 toward fresh malignant cells from patients with B-cell leukemias. Clin Cancer Res 6, 1476—87.

Pastan, I. (2003). Immunotoxins containing Pseudomonas exotoxin A: a short history. Symposium in Writing, Reisfeld, R. A. (Ed.): Cancer Immunol Immunother 52, 338—41.