Session 3: Risk Assessment

U.S. Environmental Protection Agency. (2003 ). Draft Final Guidelines for Carcinogen Risk Assessment. NCEA-F-0644A . Washington, DC, 125 pp.

Atsdr. Toxicological profile for 1,3-butadiene. Benzene. (1992). Agency for Toxic Substances and Disease Registery, U.S. Department of Health and Human Services, Public Health Service.

Melnick, R.L. , Huff, J. , Chou, B.J. , and Miller, R.A. (1990). Carcinogenicity of 1,3-Butadiene in C57Bl/6Xc3H F1-Mice at Low Exposure Concentrations. Cancer Research 50, 6592—9.

Owen, P.E. , Glaister, J.R. , Gaunt, I.F. , and Pullinger, D.H. (1987). Inhalation toxicity studies with 1,3-butadiene. 3. Two year toxicity/carcinogenicity study in rats. Am. Ind. Hyg. Assoc. J. 48, 407—13.

Delzell, E. , Sathiakumar, N. , Hovinga, M. , Macaluso, M. , Julian, J. , Larson, R. , Cole, P. , and Muir, D.C. (1996). A follow-up study of synthetic rubber workers . Toxicology 113, 182—9.

Divine, B.J. , and Hartman, C.M. (1996). Mortality update of butadiene production workers . Toxicology 113, 169—81.

Swenberg, J.A. , Koc, H. , Upton, P.B. , Georgieva, N. , Ranasinghe, A. , Walker, V.E. , and Henderson , R. (2001). Using DNA and hemoglobin adducts to improve the risk assessment of butadiene . Chem. Bio. Inter. 135—136, 387— 403.

Jayaraj, K. , Georgieva, N.I. , Gold, A. , Sangaiah, R. , Koc, H. , Klapper, D.G. , Ball, L.M. , Reddy, A.P. , and Swenberg, J.A. (2003). Synthesis and characterization of peptides containing a cyclic Val adduct of diepoxybutane, a possible biomarker of human exposure to butadiene. Chem Res Toxicol 16, 637—43.

Ellinger-Ziegelbauer, H. , Stuart, B. , Wahle, B. , Bomann, W. , and Hans-Jurgen , A. (2204). Toxicol Sci 77, 19—34.

Newton, R. , Thybaud, V. , Boitier, E. , Lynch, A. , Harvey, J. , Minnick, D. , Morris, S. , Sistare, F. , MacGregor, J. , Fornace, A. , Amundson, S. , Aubrecht, J. , Aardema, M. , Vanparys, P. , Van Goethem, F. , Staedtler, F. , Mueller, L. , Martus, H. , and Bolcsfoldi, G. (2003). Assessment of DNA microarrays as a tool for characterizing genotoxicity. Toxicogenomics in Risk Assessment Assessing the Utility, Challenges, and Next Steps. June 5—6, Hyatt Fair Lakes, Virginia.