Serum Troponins as Biomarkers of Drug-Induced Cardiac Toxicity

Adamcova, M. , V. Gersl , R. Hrdina , M. Melka , Y. Mazurove , J. Vavrova , V. Palicka , and Z. Kokstein (1999a). “Cardiac Troponin T as a Marker of Myocardial Damage Caused by Antineoplastic Drugs in Rabbits.” J Cancer Res Clin Oncol 125: 268—74.

Adamcova, M. , Z. Kokstein , V. Palicka , J. Vavrova , M. Kostal , M. Podholova , and P. Kalons (1999b). “Cardiac Troponin T in Pregnant Women Having Intravenous Tocolytic Therapy.” Arch Gynecol Obstet 262: 121—6.

Adams, J. III, D. Abendschein , and A. Jaffe (1990). “Biochemical Markers of Myocardial Injury. Is MB Creatine Kinase the Choice for the 1990's?” Circulation 88: 750—63.

Ammann P. , T. Fehr , E.I. Minder , C. Gunter , and O. Bertel (2001). “Elevation of Troponin I in Sepsis and Septic Shock.” Intensive Care Med 27: 965—9.

Amos, L. (1985). “Structure of Muscle Filaments Studied by Electron Microscopy.” Ann Rev Biophys Biophys Chem 14: 291—313.

Anderson, P.A.W. , N.N. Malouf , A.E. Oakeley , E.D. Pagani , and P.D. Allen (1991). “Troponin Isoform Expression in Humans: A Comparison Among Normal and Failing Adult Heart, Fetal Heart and Adult and Fetal Skeletal Muscle.” Circ Res 69: 1226—33.

Antman, E.M. and E. Braunwald (2001). Acute myocardial infarction. Heart Disease. E. Braunwald, D. P. Zipes, and P. Libby. WB Saunders, Philadelphia.

Apple, F.S. (1999a). “Creatine Kinase Isoforms and Myoglobin: Early Detection of Myocardial Infarction and Reperfusion.” Coron Artery Dis 10: 75—9.

Apple, F.S. (1999b). “Tissue Specificity of Cardiac Troponin I, Cardiac Troponin T and Creatine Kinase-MB.” Clin Chim Acta 284: 151—9.

Berson, G. , J.L. Samuel , and B. Swynghedauw (1978). “A Comparative Study of the cTnI Factor from Mammalians.” Pflugers Arch 374: 277—83.

Bertinchant, J.P. , A. Polge , B. Ledermann , L. Genet , P. Fabbro-Peray , F. Raczka , J. Brunet , S. Poirey , O. Wittenberg , I. Pernel , and J. Nigond (1999b). “Relation of Minor Cardiac Troponin I Elevation to Late Cardiac Events after Uncomplicated Elective Successful Percutaneous Transluminal Coronary Angioplasty for Angina Pectoris.” Am J Cardiol 84: 51—7.

Bertinchant, J.P. , A. Polge , E. Robert , N. Sabbah , P. Fabbro-Peray , S. Poirey , M. Laprade , B. Pau, J. M. Juan, J. P. Bali, J. E., de la Coussaye, and M. Dauzat ( 1999c). “Time-Course of Cardiac Troponin I Release from Isolated Perfused Rat Hearts During Hypoxia/Reoxygenation and Ischemia/Reperfusion .” Clin Chim Acta 283: 43—56.

Bertinchant, J.P. , E. Robert , A. Polge , C. Marty-Double , P. Fabbro-Peray , S. Poirey , G. Aya , J.M. Juan , B. Lederman , J.E. de la Coussaye , and M. Dauzat , (2000). “Comparison of the Diagnostic Value of Cardiac Troponin I and T Determinations for Detecting Early Myocardial Damage and the Relationship with Histological Findings after Isoprenaline-induced Cardiac Injury in rats. Clin Chim Acta 298: 13—28.

Bertinchant, J.P. , E. Robert , A. Polge , J.E. de la Coussaye , C. Pignodel , G. Aya , P. Fabbro-Peray , S. Poirey , B. Ledermann , J.J. Eledjam , and M. Dauzat (1999a). “Release Kinetics of Cardiac Troponin I and Cardiac Troponin T in Effluents from Isolated Perfused Rabbit Hearts after Graded Experimental Myocardial Contusion.” J Trauma 47: 474—80.

Bertsch, T. , H. Bleuel , J. Aufenanger , and W. Rebel (1997). “Comparison of Cardiac Troponin T and Cardiac Troponin I Concentrations in Peripheral Blood During Orciprenaline Induced Tachycardia in Rats.” Exp Toxicol Pathol 49: 467—8.

Bleier, J. , K.P. Vorderwinkler , J. Falkensammer , P. Mair , O. Dapunt , B. Puschendorf , and J. Mair (1998). “Different Intracellular Compartmentations of Cardiac Troponins and Myosin Heavy Chains: A Causal Connection to their Different Early Release after Myocardial Damage.” Clin Chem 44: 1912—8.

Bleuel, H. , U. Deschl , T. Bertsch , G. Bolz , and W. Rebel (1995). “Diagnostic Efficiency of Troponin T Measurements in Rats with Experimental Myocardial Cell Damage.” Exp Tox Pathol 47: 121—7.

Bodor, G.S. (1994). “Cardiac Troponin I. A Highly Specific Biochemical Marker or Myocardial Infarction.” J Clin Immunoassay 17: 40—4.

Bodor, G.S. , D. Porterfield , E.M. Voss , S. Smith , and F.S. Apple (1995). “Cardiac Troponin I is Not Expressed in Fetal and Healthy or Diseased Adult Human Skeletal Muscle. Clin Chem 41: 1710—1715.

Bodor, G.S. , D. Porterfield , E.M. Voss , S. Smith , and F.S. Apple (1997). “Cardiac troponin T composition in normal and regenerating human skeletal muscle. Clin Chem 43: 476—84.

Bohner, J. , K.W. vonPape , W. Hannes , and T. Stegmann (1996). “False-Negative Immunoassay Results for Cardiac Troponin I Probably due to Circulating Troponin I Autoantibodies.” Clin Chem 42: 2046.

Bonvenuto, G.M. , L. La Vecchia , P. Morandi , P. Ruffini , and G. Mezzena (2000). “Assessment of Cardiotoxicity of High Dose Cyclophosphomide with Electrocardiographic, Echocardiographic, and Troponin I Monitoring in Patients with Breast Tumors.” Italia Heart J Off J Ital Fed Cardiol 1 (Suppl 11): 1457—63.

Braun, S.L. , D.E. Pongratz , P. Bialk , S. Liem , B. Schlotter , and W. Vogt (1996). “Discrepant Results for Cardiac Troponin T and Troponin I in Chronic Myopathy Depending on Instrument and Assay Generation .” Clin Chem 42: 2039—41.

Cantwell, R.V. , R.J. Aviles , J. Bjornsson , R.S. Wright , W.K. Freeman , J.K. Oh , J.D. Hoyer , S. Markovic , and A.S. Jaffe (2002). “Cardiac Amyloidosis Presenting with Elevations of Cardiac Troponin I and Angina pectoris.” Clin Cardiol 25(1): 33—7.

Cheesebro, M.J. (1997). “Using Serum Markers in the Early Diagnosis of Myocardial Infarction.” Am Fam Phys 55: 2667—74.

Chiang, V.W. , J.P. Burns , N. Rifai , S.E. Lipshultz , J. Adamson , and D.L. Weiner (2000). “Cardiac Toxicity of Intravenous Terbutaline for the Treatment of Severe Asthma in Children: A Prospective Assessment.” J Ped 137(1): 73—7.

Childs, A.C. , S.L. Phaneuf , A.J. Dirks , T. Phillips , and C. Leeuwenburgh (2002). “Doxorubicin Treatment in vivo Causes Cytochrome C Release and Cardiomyocyte Apoptosis as Well as Increased Mitochondrial Efficiency, Superoxide Dismutase Activity and Bcl-:Bax Ratio.” Cancer Res 62: 4592—8.

Christenson, R.H. , S. Hong Duh , F.S. Apple , G.S. Bodor , D.M. Bunk , J. Dalluge , M. Panteghini , J.D. Potter , M.J. Welch , A.H. Wu and S.E. Kahn (2001). “Standardisation of Cardiac Troponin I Assays: Round Robin of Ten Candidate Reference Materials.” Clin Chem 47: 431—7.

Christenson, R.H. , L.K. Mewby , and E.M. Ohman (1997). “Cardiac Markers in the Assessment of Acute Coronary Syndromes.” Md Med J Suppl: 18—24.

Christansen, S. , K. Redmann , H.H. Scheld , V.R. Jahn , J. Stypmann , M. Fobker , A.D. Gruber , and D. Hammel (2002). “Adriamycin-Induced Cardiomyopathy in the Dog—An Appropriate Model for Research on Partial Left Ventriculectomy . J Heart Lung Transpl 21: 783—90.

Chu, W.W. , R.S. Dieter , and C.K. Stone (2002). “A Review of Clinically Relevant Cardiac Biochemical Markers.” Wisconsin Med J 101: 40—8.

Collinson, P.O. , F.G. Boa , and D.C. Gaze (2001). “Measurement of Cardiac Troponins.” Ann Clin Biochem 38: 423—49.

Collinson, P.O. , N. Wiggins , and D.C. Gaze (2001). “Clinical Evaluation of the ACS: 180 Cardiac Troponin I Assay.” Ann Clin Biochem 38: 509— 19.

Cook, R. (1986). “The Mechanisms of Muscle Contraction.” CRC Crit Rev Biochem 21: 53—118.

Corin, S.J. , O. Juhasz , L. Zhu , P. Conley , L. Keded , and R. Wade (1994). “Structure and Expression of Human Slow Twitch Skeletal Muscle Troponin I Gene.” J Biol Chem 269: 10651—9.

Curtis, B.M. and J.H. O'Keefe (2002). “Autonomic Tone as a Cardiovascular Risk Factor: The Dangers of Chronic Fight or Flight.” Mayo Clin Proc 77: 45—54.

Dare, T.O. , H.E. Billings , S.A. Curran , S.A.M. Selway , M.A. Price , T.C. Williams , and M.J. York (1999). “The use of Cardiac Troponin I (cTnI) for the early detection of cardiac damage in Wistar Han Rats.” Abstract in Proc ACB Nat Mtg, Manchester, UK.

Davilla-Roman, V.G. , T.M. Guest , P.G. Tuteur , W.J. Rowe , J.H. Ladenson , and A.S. Jaffe (1997). “Transient Right But Not Left Ventricular Dysfunction After Strenuous Exercise at High Altitude.” J Am Coll Cardiol 30: 468—73.

de Lemos, J.A. , E.M. Antman , and R. Schroder (2000). “Very Early Risk Stratification After Thrombolytic Therapy Using a Bedside Myoglobin Assay and the 12-lead ECG.” Am Heart J 140: 373—8.

Dean, K.J. (1998). “Biochemistry and Molecular Biology of Troponin I and T.” Cardiac Markers. A.H.B. Wu, Humana, Totowa, NJ, pp. 193—204.

Ebashi, S. , T. Wakabayashi , and F. Ebashi (1971). “Troponin and its Components.” J Biochem (Tokyo) 69: 441—5.

Erlacher, P. , A. Lercher , J. Falkensammer , E.L. Nassonov , M.I. Samsonov , V.Z. Shtutman , B. Puschendorf , and J. Mair (2001). “Cardiac (Troponin and Beta-Type Myosin Heavy Chain Concentrations in Patients with Polymyositis and Dermatomyositis .” Clin Chim Acta 306(1—2): 27— 33.

Erwin, M.B. and E.N. Deliargyris (2002). “Cocaine-Associated Chest Pain.” Am J Med Sci 324: 37—44.

Fantoni, M. , C. Autore , and C. Del Borgo (2001). “Drugs and Cardiotoxicity in HIV and AIDS.” Ann NY Acad Sci 946: 179—99.

Farah, C.S. and F.C. Reinach (1995). “The Troponin Complex and Regulation of Muscle Contraction.” FASEB J 9: 755—67.

Ferrans, V.J. (1978). “Overview of Cardiac Pathology in Relation to Anthracycline Cardiotoxicity.” Cancer Treat Rep 62: 955—61.

Fleming, S. , L. O'Byrne , J. Finn , H. Grimes , and K.M. Daly (2002). “False-Positive Cardiac Troponin I in a Routine Clinical Population” Am J Cardiol 89: 1212—3.

Flicker, P.F. , G.N. Phillips Jr. , and C. Cohen (1982). “Troponin and its Interactions with Tropomysin: An Electron Microscopic Study.” J Mol Biol 162: 495—501.

Fredericks, S. , G.K. Merton , M.J. Lerena , P. Heining , N.D. Carter , and D.W. Holt (2001). “Cardiac Troponins and Creatine Kinase Content of Striated Muscle in Common Laboratory Animals.” Clin Chim Acta 304: 65—74.

Frey, N. , M. Muller-Bardorff , and H.A. Katus (1998). “Myocardial Damage: Early Detection by Novel Biochemical Markers.” Myocardial Damage: The Role of Troponin T. J. C. Kaski, and D. W. Holt, Kluwer Academic Publishers, Boston.

Gerhardt, W. and L. Ljungdahl (1998). “Troponin T: A Sensitive and Specific Diagnostic and Prognostic Marker of Myocardial Damage.” Clin Chim Acta 272: 47—57.

Giantris, A. , L. Abdurrahman , A. Hinkle , B. Asselin , and S.E. Lipshultz (1998). “Anthracycline-induced Cardiotoxicity in Children and Young Adults.” Crit Rev Oncol/Hematol 27: 53—68.

Gottlieb, R.A. , K.O. Burleson , R.A. Kloner , B.M. Babior , and R.L. Engler (1994). “Reperfusion injury induces apoptosis in rabbit cardiomyocytes.” J Clin Invest 94: 1621—8.

Greaser, M. and J. Gergely (1973). “Purification and Properties of the Components from Troponin.” J Biol Chem 248: 2125—33.

Gulati, J. , A.B. Akella , S.D. Nikolic , V. Starc , and F. Siri (1994). “Shifts in Contractile Regulatory Protein Subunits Troponin T and Troponin I in Cardiac Hypertrophy. Biochem Biophys Res Commun 202: 384—90.

Haller, C. , J. Zehelein , A. Remppis , M. Muller-Bardorff , and H.A. Katus (1998). “Cardiac Troponin T in Patients with Endstage Renal Disease: Absence of Expression in Truncal Skeletal Muscle.” Clin Chem 44: 930—8.

Herman, E.H. and V.J. Ferrans (1998). “Preclinical Models of Cardiac Protection from Anthracycline-Induced Cardiotoxicity.” Semin Oncol 25 (Suppl 10): 15—21.

Herman, E.H. and V.J. Ferrans (2001). “The Use of Cardiac Biomarkers for the Detection of Drug-Induced Myocardial Damage.” Markers in Cardiology: Current and Future Clinical Applications, J. E. Adams III, F. S. Apple, A. S. Jaffe, and A. H. B. Wu Futura Publishing Co, Armonk, New York.

Herman, E.H. , S.E. Lipshultz , N. Rifai , J. Zhang , T. Papoian , X. Yuz , K. Takeda , and V.J. Ferrans (1998). “Use of Cardiac Troponin T Levels as an Indicator of Doxorubicin-Induced Cardiotoxicity.” Cancer Res 58: 195—7.

Herman, E.H. , J. Zhang , S. Lipshultz , N. Rifai , D. Chadwick , K. Takeda , Z.X. Yu and V.J. Ferrans (1999). “Correlation Between Serum Levels of Cardiac Troponin-T and the Severity of the Chronic Cardiomypoathy Induced by Doxorubicin .” J Clin Oncol 17: 2237—43.

Herman, E.H. , J. Zhang , N. Rafai , S.E. Lipshultz , B.B. Hasinoff , D.P. Chadwick , A. Knapton , J. Chai , and V.J. Ferrans (2001). “The use of Serum Levels of Cardiac Troponin T to Compare the Protective Activity of Dexrozoxane Against Doxorubicin- and Mitoxantrone-Induced Cardiotoxicity. Cancer Chemother Pharmacol 48: 297—304.

Jaffe, A.S. (2001) “Elevations in Cardiac Troponin Measurements: False False-Positives. The Real Truth.” Cardiovasc Toxicol 1: 87—92.

Jaffe, A.S. , J. Ravkilde , R. Roberts , U. Naslund , F.S. Apple , M. Galvani , and H. Katus (2000). “It's Time for a Change to a Troponin Standard .” Circulation 102: 1216—20.

Joint European Society of Cardiology/American College of Cardiology Committee (2000a). “Myocardial Infarction Redefined—A Consensus Document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction .” J Amer Coll Cardiol 36: 959—68.

Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction ( 2000b). “Myocardial Infarction Redefined—A Consensus Document.” Eur Heart J 21: 1502— 13.

Karczewski, P. , S. Bartel , and E.-G. Krause (1993). “Protein Phosphorylation in the Regulation of Cardiac Contractibility and Vascular Smooth Muscle Tone.” Curr Opin Nephrol Hypertens 2: 33—40.

Katrukha, A.G. , A.V. Bereznikova , T.V. Esakova , K. Petterson , T. Lovgren and M.E. Severina (1997). “Troponin I is Released in Bloodstream of patients with Acute Myocardial Infarction Not in Free Form but as a Complex .” Clin Chem 43: 1379—85.

Katus, H.A. , A. Remppis , T. Scheffold , K.W. Diederich , and W. Kuebler (1991). “Intracellular Compartmentation of Cardiac Troponin T and its Release Kinetics in Patients with Reperfused and Nonreperfused Myocardial Infarction.” Am J Cardiol 67: 1360—7.

Katus, H.A. , T. Scheffold , A. Remppis , and J. Zehlein (1992). “Proteins of the Troponin Complex.” Lab Med 23: 311—7.

Kawakami, T. , C. Lowbeer , G. Valen , and J. Vaage (1999). “Post-Ischemic Dysfunction Does Not Correlate with Release of Cardiac Troponin T in Isolated Rat Hearts.” Acta Physiol Scand 167: 23—7.

Keefe, D.L. (2002). “Trastuzumab-Associated Cardiotoxicity.” Cancer 95(7): 1592—600.

Kim, M. and K. Kim (1999). “Elevation of Cardiac Tropnin I in the Acute Stage of Kawasaki Disease.” Pedia Cardiol 20: 184—8.

Kitsis, R.N. and J. Scheuer (1996). “Functional Significance of Alterations in Cardiac Contractile Protein Isoforms.” Clin Cardiol 19: 9—18.

Knoblock, R.J. , C.M. Lehman , R.A. Smith , F.S. Apple , and W.L. Roberts (2002). “False-positive AxSYM cardiac Troponin I Results in a 53-Year old Woman.” Arch Pathol Lab Med 126: 606—9.

Kontos, M.C. , F.P. Anderson , J.P. Ornato , J.L. Tatum , and R.L. Jesse (2002). “Utility of Troponin I in Patients with Cocaine-Associated Chest Pain.” Acad Emerg Med 9: 1007—13.

Krischer, J.P. , S. Epstein , D.D. Cuthbertson , A.M. Goorin , M.L. Epstein , and S.E. Lipshultz (1997). “Clinical Cardiotoxicity Following Anthracycline Treatment for Childhood Cancer: The Pediatric Oncology Group Experience.” J Clin Oncol 15(4): 1544—52.

Krishan, K. and G.K. Dhoot (1996). “Changes in Some Troponin and Insulin-Like Growth Factor Messenger Ribonucleic Acids in Regenerating and Denervated Skeletal Muscles.” J Muscle Res Cell Motil 17: 513— 21.

Kruit, W.H. , K. J. Punt, S.H. Goey, P.H. de Mulder, D.C. van Hoogenhuyze S. C. Henzen-Logmans , and G. Stoter (1994). “Cardiotoxicity as a Dose-Limiting Factor in a Schedule of High Dose Bolus Therapy with Interleukin-2 and Alpha-interferon . An Unexpectedly Frequent Complication.” Cancer 74(10): 2850—6.

Leavis, P. and J. Gergely (1984). “Thin Filament Proteins and Thin Filament Linked Regulation of Vertebrate Muscle Contraction.” CRC Crit Rev Biochem 16: 235—305.

Levin, E.R. , D.G. Gardner , and W.K. Samson (1998). “Natriuretic Peptides.” New Engl J Med 339: 321—8.

Lindahl, B. , H. Toss , A. Siegbahn , P. Venge , and L. Wallentin (2000). “Markers of Myocardial Damage and Inflammation in Relation to Long-Term Mortality in Unstable Coronary Artery Disease. New Engl J Med 343: 1139—47.

Lipshultz, S.E. , N. Rafai , S.E. Sillan , S.R. Lipsitz , V. Dalton , D.B. Socks , and M.E. Ottlinger (1997). “Predictive Value of Cardiac Troponin T in Pediatric Patients at Risk for Myocardial Injury.” Circulation 96(8): 2641— 48.

Lobetti, R. , E. Dvir , and J. Pearson (2002). “Cardiac Troponins in Canine Babesiosis .” J Vet Intern Med 16: 63—8.

Lodish, H. , A. Berk , L. Zipursky , P. Matsudiara , D. Baltimore and J. Darnell (1995). Molecular Cell Biology. 3rd ed, WH Freeman, New York, pp. 1021—1032.

Luchner, A. , T.L. Stevens , D.D. Borgeson , M. Redfield , C.M. Wei , and J.C. Brunett Jr (1998). “Differential Atrial and Ventricular Expression of Myocardial BNP During Evolution of Heart Failure.” Am J Physiol 274: H1684—9.

Machackova J. , M. Adamcova , Y. Mazurova , R. Hrdina , and M. Noblis (2001). “Evaluation of Cardiac Effects of the New Antineoplastic Drug Dimethoxybenfluron in the Rabbit.” Physiol Res 50: 491—9.

Maeda, K. , T. Tsutomoto , A. Wada , T. Hisanaga , and M. Kinoshita (1998). “Plasma Brain Natriuretic Peptide as a Biochemical Marker of High Left Ventricular End-Diastolic Pressure in Patients with Symptomatic Left Ventricular Dysfunction.” Am Heart J 135: 825—32.

Mahla, E. , K. Tiesenhausen , P. Rehak , S. Fruhwald , P. Purstner , and H. Metzler (2000). “Perioperative Myocardial Cell Injury: The Relationship Between Troponin T and Cortisol.” J Clin Anes 12: 208—12.

Mair, J. (1997). “Progress in Myocardial Damage Detection: New Biochemical Markers for Clinicians.” Crit Rev Clin Lab Sci 34: 1—66.

Mair, J. , I. Wagner , B. Morass , L. Fridrich , P. Lechleitner F. Dienstl C. Calzolari , C. Larue , and B. Puschendorf (1995). “Cardiac Troponin I Release Correlates with Myocardial Infarction Size.” Eur J Clin Chem Clin Biochem 33: 869—72.

Maisel, A.S. , P. Krishnaswamy , R.M. Nowak , J. McCord , J.E. Hollander , P. Duc , T. Omland , A.B. Storrow , W.T. Abraham , A.H.B. Wu et al. (2002). “Rapid Measurement of B-type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure.” New Engl J Med 347: 161—7.

Malouf, N.N. , D. McMahon , A.E. Oakeley , and P.A. Anderson (1992). “A Cardiac Troponin T Epitope Conserved Across Phyla.” J Biol Chem 267: 9269—74.

Martin, A.F. (1981). “Turnover of Cardiac Troponin Subunits.” J Biol Chem 256: 964—8.

Masuda, T. , K. Sato , S. Yamamoto , N. Matsuyama , T. Shimohama , A. Matsunaga , S. Obuchi , Y. Shiba , S. Shimizu , and T. Izumi (2002). “Sympathetic Nervous Activity and Myocardial Damage Immediately after Subarachnoid Hemorrhage in a Unique Animal Model .” Stroke 33: 1671—6.

McDonough, J.L. , D.K. Arrell , and J.E. VanEyk (1999). “Troponin I Degradation and Covalent Complex Formation Accompanies Myocardial Ischemia/Reperfusion Injury.” Circ Res 84: 9—20.

McLeurin, M. , F.S. Apple , T.D. Henry et al. (1996). “Cardiac Troponin I and T Concentrations in Patients with Cocaine-Associated Chest Pain.” Ann Clin Biochem 33: 183—6.

McLeurin, M.D. , F.S. Apple , E.M. Voss , C.A. Herzog , and S.W. Sharkey (1997). “Cardiac Troponin I, Cardiac Troponin T and Creatine Kinase MB in Dialysis Patients Without Ischemic Heart Disease: Evidence of Cardiac Troponin T Expression in Skeletal Muscle.” Clin Chem 43: 976— 82.

Mesnard, L. , F. Samson , I. Espinasse , J. Durand , J.Y. Neveux , and J.J. Mercadier (1993). “Molecular Cloning and Developmental Expression of Human Cardiac Troponin T.” FEBS Lett 328: 139—44.

Messner, B. , H. Baum , P. Fischer , S. Quasthoff , and D. Neumeier (2000). “Expression of Messenger RNA of the Cardiac Isoforms of Troponin T and I in Myopathic Skeletal Muscle.” Clin Chem 114: 544—9.

Nadal-Ginard, B. and V. Mahdaui (1989). “Molecular Basis of Cardiac Performance .” J Clin Invest 84: 1693—700.

Nosanchuk, J.S. (1999). “False Increases of Troponin I Attributable to Incomplete Separation of Serum. Clin Chem 45: 714.

O'Brien, P.J. , G.W. Dameron , M.L. Beck Y.J. Kang , B.K. Erickson , and T. H. Di Battista K.E. Miller K.N. Jackson and S. Mittelstadt (1997a). “ Cardiac Troponin T is a Sensitive, Specific Biomarker of Cardiac Injury in Laboratory Animals.” Lab Anim Sci 47: 486—95.

O'Brien, P.J. , G.W. Dameron , M.L. Beck , and M. Brandt (1998). “Differential Reactivity of Cardiac and Skeletal Muscles from Various Species in Two Generations of Cardiac Troponin T Immunoassays.” Res Vet Sci 65: 135—7.

O'Brien, P. , Y. Lanott , and J. Ladenson (1997b). “Differential Reactivity of Cardiac and Skeletal Muscle from Various Species in a Cardiac Troponin-I Immunoassay.” Clin Chem 43: 2333—8.

Ooi, D.S. , P.A. Isotalo , and J.P. Veinot (2000). “Correlation of Antemortum Serum Creatine Kinase, Creatine Kinase-MB, Troponin I, and Troponin T with Cardiac Pathology .” Clin Chem 46: 338—44.

Patel, V.B. , R. Ajmal , R.A. Sherwood , A. Sullivan , P.J. Richardson , and V.R. Preedy (2001). “Cardioperotective Effect of Propanolol from Alcohol Induced Heart Muscle Damage as Assessed by Plasma Cardiac Troponin, T. Alcohol. Clin Exp Res 25: 882—9.

Pearlstone, J.R. , M.R. Carpenter , and L.B. Smille (1986). “Amino Acid Sequence of Rabbit Cardiac Troponin T.” J Biol Chem 261: 16795—810.

Pinelli, A. , S. Trivulzio , L. Tomasoni , B. Bertolini , S. Brenna , and E. Bonacina (2002). “Cardiac Necrosis Markers Associated with Low Nitric Oxide Levels in the Plasma of Rabbits after Treatment with Vasopression: Protective Effects of Nitroglycerin Administration.” Pharmacol Res 45: 427—34.

Plebani, M. , M. Mion , S. Altinier , M.A. Girotto , G. Baldo , and M. Zaninotto (2002). “False-Positive Troponin I Attributed to a Macrocomplex.” Clin Chem 48: 677—8.

Potter, J.D. , Z. Sheng , B.- S. Pan , and J. Zhao (1995). “A Direct Regulatory Role for Troponin T and a Dual Role for Troponin C in the Ca+2 Regulation of Muscle Contraction .” J Biol Chem 270: 2557—62.

Quirk, P.G. , V.B. Patchell , Y. Gao , B.A. Levine , and S.V. Perry (1995). “Sequential Phosphorylation of Adjacent Serine Residues on the n-Terminal Region of Cardiac Troponin-I: Structure Activity Implications of Ordered Phosphorylation.” FEBS Lett 370: 175—8.

Remme, W.J. and K. Swedberg (2002). “Comprehensive Guidelines for the Diagnosis and Treatment of Chronic Heart Failure. Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology.” Eur J Heart Fail 4: 11—22.

Remppis, A. , P. Ehlermann , E. Giannitis , T. Greten , P. Most , M. Muller-Bardoff , and H.A. Katus (2000). “Cardiac Troponins at 96 Hours Reflect Myocardial Infarct Size: A Pathoanatomical Study.” Cardiology 93: 249—53.

Remppis, A. , T. Scheffold , J. Greten , M. Haass , T. Greten , W. Kubler , and H.A. Katus (1995). “Intracellular Compartmentation of Troponin T: Release Kinetics After Global Ischemia and Calcium Paradox in the Isolated Perfused Rat Heart.” J Mol Cell Cardiol 27(2): 793—803.

Ricchiuti, V. , E.M. Voss , A. Ney , M. Odland , P.A.W. Anderson , and F.S. Apple (1998). “Cardiac Troponin T Isoforms Expressed in Renal Diseased Skeletal Muscle will not Cause False-Positive Results by the Second Generation Cardiac Troponin T Assay by Boehringer Mannheim.” Clin Chem 44: 1919—24.

Ridker, P.M. , N. Rifai , L. Rose , J.E. Buring , and N.R. Cook (2002). “Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events .” New Engl J Med 347: 1557—65.

Roberts, R. (1990). “Enzymatic Estimation of Infarct Size: Thrombolysis Induced its Demise: Will it Now Rekindle its Renaissance?” Circulation 81: 707—10.

Saggin, L. , L. Gorza , S. Ausoni , and S. Schiaffino (1990). “Cardiac Troponin T in Developing, Regenerating and Denervated Rat Skeletal Muscle.” Development 110: 547—54.

Sakamoto, H. , H. Nishimura , K. Imataka K. Ieki , T. Horie , and J. Fujii (1996). “Abnormal Q Wave, ST-Segment Elevation, T-Wave Inversion, and Widespread Focal Myocytolysis Associated with Subarachnoid Hemorrhage.” Jpn Circ J 60(4): 254—7.

Sakr, Y.L. , I. Ghosn , and J.L. Vincent (2002). “Cardiac Manifestations after Subarachnoid Hemorrhage: A Systematic Review of the Literature.” Prog Cardiovasc Dis 45(1): 67—80.

Sasse, S. , N.J. Brand , P. Kyprianou , G.K. Dhoot , R. Wade , M. Arai , M. Periasamy M.H. Yacoub , and P.J. Barton (1993). “Troponin I Gene Expression During Human Cardiac Development and in End-Stage Heart Failure.” Circ Res 72: 932—8.

Scripps (1994). SCRIPPS Reports: Drug Withdrawal from Sale. 2nd ed. PJB Publications, Richmond, Surrey, UK.

Seino, Y. , Y. Tomita , Y. Nagai , Y. Kusama , H. Hayakawa , T. Sasaki , and I. Horii (1993). “Cardioprotective Effects of ACE-Inhibitor (cilazapril) on Adriamycin Cardiotoxicity in Spontaneously Hypertensive Rats .” Circulation 88: 1633.

Smith, S.C. , J.H. Ladenson , J.W. Mason , and A.S. Jaffe AS (1997). “Elevations of Cardiac Troponin I Associated with Myocarditits. Experimental and Clinical Correlates.” Circulation 95(1): 163—8.

Sutherland, C.J. , K.A. Esser , V.L. Elsom , M.L. Gordon , and E.C. Hardeman (1993). “Identification of a Program of Contractile Protein Gene Expression Initiated Upon Skeletal Muscle Differentiation.” Dev Dyn 196: 25—36.

Thomas, S.A. , J.A. Fallavollita , T.C. Lee et al. (1999). “Absence of Troponin I Degradation of Altered Sarcoplasmic Reticulum Uptake Protein Expression after Reversible Ischemia in Swine.” Circ Res 85: 446—56.

Tobacman, L.S. and R. Lee (1987). “Isolation and Functional Comparison of Bovine Cardiac Troponin Isoforms.” J Biol Chem 262: 4059—64.

Townsend, P.J. , H. Farza , C. MacGeoch , K.N.K. Spurr , R. Wade , R. Gahlaman , M. Yocoub , and P.J. Barton (1994). “Human Cardiac Troponin T Identification of Fetal Isoforms and Assignment of the TNNT2 Locus to Chromosome 1q.” Genomics 21: 311—6.

Tsung, J.S. and S.S. Tsung (1986). “Creatine Kinase Isoenzymes in Extracts of Various Human Skeletal Muscles.” Clin Chem 32: 1568—70.

Uettwiller-Geiger, D. , A.H. Wu , F.S. Apple , A.W. Jevans , P. Nenge , M.D. Olson , C. Dartte , D.L. Woodrum , and S. Roberts Chan (2002). “Multicenter Evaluation of an Automated Assay for Troponin I. Clin Chem 48: 869—76.

Vallins, W.J. , N.J. Brand , N. Dabhade , G. Butler-Browne , M.H. Yacoub , and P.J.R. Barton (1990). “Molecular Cloning of Human Cardiac Troponin I Using Polymerase Chain Reaction.” FEBS Lett 270: 57—61.

Venema, R.C. and J.F. Kao (1993). “Protein Kinase C Mediated Phosphorylation of Troponin I and C-Protein in Isolated Myocardial Cells is Associated with Inhibition of Myofibrillar Actinomysin Mg ATPase.” J Biol Chem 268: 2705—11.

Von Hoff, D.D. , M. Rozencweig , and M. Piccart (1982). “The Cardiotoxicity of Anticancer Agents .” Semin Oncol 9: 23—33.

Voss, E.M. , S.W. Sharkey , A.E. Gernert , M.M. Murakami , R.B. Johnston , C.C. Hsieh , and F.S. Apple (1995). “Human and Canine Cardiac Troponin T and Creatine Kinase MB Distribution in Normal and Diseased Myocardium: Infarct Sizing Using Serum Profiles.” Arch Pathol LAB Med 119: 799—806.

Wade, R. , R. Eddy , T.B. Shows , and L. Kedes (1990). “cDNA Sequence, Tissue Specific Expression and Chromosomal Mapping of the Human Slow-Twitch Skeletal Muscle Isoform of Troponin I.” Genomics 7: 346—57.

Wade, R. and L. Kedes (1989). “Developmental Regulation of Contractile Protein Genes.” Ann Rev Physiol 51: 179—88.

Welsh, T.M. , G.D. Kukes , and L.M. Sandweiss (2002). “Differences of Creatine Kinase MB and Cardiac Troponin I Concentrations in Normal and Diseased Human Myocardium.” Ann Clin Lab Sci 32(1): 44—9.

Wilkinson, J.M. and R.J.A. Grand (1978). “Comparison of Amino Acid Sequences of Troponin I from Different Striated Muscles.” Nature 271: 31—5.

Wu, A.H. (1994). “Cardiac Troponin T: Biochemical, Analytical and Clinical Aspects.” J Clin Immmunoassay 17: 45—8.

Wu, A.H. (1999a). “Biochemical Markers of Cardiac Damage: Form Traditional Enzymes to Cardiac Specific Proteins.” Scand J Clin Lab Invest 50 (Suppl. 230): 74—82.

Wu, A.H. , F.S. Apple , W.B. Gibler , R.L. Jesse , M.M. Warshaw , and R. Valdes Jr (1999b).” National Academy of Clinical Biochemistry Standards of Laboratory Practice: Recommendations for the Use of Cardiac Markers in Coronary Artery Diseases.” Clin Chem 45: 1104—21.

Wu, A.H. , Y.J. Feng , R. Moore , F.S. Apple , P.H. Mcpherson , K.F. Buechler , and G. Bodor (1998). “Characterisation of Cardiac Troponin Subunit Release into Serum after Acute Myocardial Infarction and Comparison of Assays for Troponin T and I.” Clin Chem 44: 1198—208.

Wu, H.B. and L. Ford (1999). “Release of Cardiac Troponin in Acute Coronary Syndromes: Ischemia or Necrosis?” Clin Chim Acta 284: 161—74.

Zot, A.S. and J.D. Potter (1987). “Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction.” Ann Rev Biophys Chem 16: 535—59.