Expression of p63 and 14-3-3σ in Normal and Hyperdifferentiated Mucosa of the Upper Aerodigestive Tract

Abstract

OBJECTIVE:

Our goal was to analyze p63 and 14-3-3σ expression in normal and hyperdifferentiated head and neck mucosa.

STUDY DESIGN:

Compare the in vivo expression of p63 and 14-3-3σ by immunohistochemistry in normal mucosa and oral lichen planus, a benign mucosal lesion marked by hyperdifferentiation and apoptosis.

RESULTS AND CONCLUSION:

p63 is underexpressed and 14-3-3σ is overexpressed in lichen planus on immunohistochemical analysis.

SIGNIFICANCE:

The findings support the hypothesis that p63 plays an antidifferentiation role, whereas 14-3-3σ plays a prodifferentiation role in the upper aerodigestive tract epithelium. Lichen planus is a valuable model for the study of p63, 14-3-3σ, and mucosal differentiation. p63 and 14-3-3σ may be molecular markers for oral lichen planus.

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