Neuroanatomic, morphometric, immunocytochemical, neurobiochemical and clinical data support the hypothesis that the suprachiasmatic nucleus of the hypothalamus might be the initial site of migraine attacks. The prodromal phase of a migraine attack could be considered a syndrome of functional suprachiasmatic nucleus insufficiency, and other phases a reactive denervation hypersensitivity with the affection of the visual, nociceptive, antinoacceptive and cranial vasomotor system.
LanceJW.Mechanism and management of headache.
Oxford:
Butterworth-Heinemann,
1993:
68–111
3.
LauritzenM.Regional cerebral blood flow during migraine attacks by Xenon-133 inhalation and emission tomography.
Brain1984;
107:
457–61
4.
SicuteriF.Hypothesis: Migraine, a central biochemical dysnociception.
Headache1976;
16:
145–59
5.
SicuteriF.Endorphins, opiate receptors and migraine headache.
Headache1978;
17:
253–6
6.
SilbersteinSD.Advances in understanding the pathophysiology of headache.
Neurology1992;
42Suppl 2:
6–10
7.
WelchKMA.Migraine.
A biobehavioral disorder, Arch Neurol1987;
44:
323–7
8.
HardeboJE.Migraine—why and how a cortical excitatory wave may initiate the aura and headache.
Headache1991;
31:
213–21
9.
OlsenTS.Migraine with and without aura: the same disease due to cerebral vasospasm of different intensity. A hypothesis based on CBF studies during migraine.
Headache1990;
30:
269–72
10.
BruynGW.The biochemistry of migraine.
Headache1980;
20:
235–46
11.
RaoNSPearceJ.Hypothalamic-pituitary-adrenal axis studies in migraine with special reference to insulin sensitivity.
Brain1971;
94:
289–98
12.
BraakHBraakE.The hypothalamus of the human adult: chiasmatic region.
Anat Embryol1987;
176:
315–30
13.
EdgarDM.Functional role of the suprachiasmatic nuclei in the regulation of sleep and wakefulness.
In:
GuilleminaultCLugaresiEMontagnaPGambettiP,
Fatal familial insomnia, inherited prion diseases, sleep and the thalamus.
New York:
Raven Press,
1994:
203–13
14.
HofmanMAZhouJNSwaabDF.Suprachiasmatic nucleus of the human brain: an immunocytochemical and morphometric analysis.
Amat Rec1996;
244:
552–62
15.
MaiJKKedzioraOTreckhausLSofroniewMV.Evidence for subdivisions in the human suprachiasmatic nucleus.
J Comp Neurol1991;
305:
508–25
16.
HofmanMASwaabDF.The human hypothalamus: comparative morphometry and photoperiodic influences.
In:
SwaabDFHofmanMAMirmiranMRavidRvan LeeuwenFW,
Progress in brain research,
vol. 93:
Amsterdam:
Elsevier,
1992:
133–47
17.
HofmanMASwaabDF.Sexual dimorphism of the human brain: myth and reality.
Exp Clin Endocrinol1991;
98:
2,
161–70
18.
SwaabDFGoorenLJGHofmanMA.The human hypothalamus in relation to gender and sexual orientation.
In:
SwaabDFHofmanMAMirmiranMRavidRvan LeeuwenFW,
Progress in brain research,
vol. 93:
Amsterdam:
Elsevier,
1992:
205–17
19.
SwaabDFHofmanMALucassenPJPurbaJSRaadsheerFCVan de NesJA.Functional neuroanatomy and neurophysiology of the human hypothalamus.
Anat Embryol1993;
187
(4):
317–30
20.
HofmanMAPurbaJSSwaabDF.Annual variations in the vasopressin neuron population of the human suprachiasmatic nucleus.
Neuroscience1993;
53:
4,
1103–12
21.
HofmanMASwaabDF.Effects of light and aging on the human suprachiasmatic nucleus.
In:
NakagawaHOomuraYNagaiK,
New functional aspects of the suprachiasmatic nucleus of the hypothalamus.
London:
J Libbey,
1993:
201–17
22.
NieuwenhuysR.Chemoarchitecture of the brain.
Berlin:
Springer,
1985:
177–81
23.
MooreRY.Functional organization of the suprachiasmatic nucleus.
In:
GuilleminaultCLugaresiEMontagnaPGambettiP,
Fatal familial insomnia, inherited prion diseases, sleep and thalamus.
New York:
Raven Press,
1994:
191–201
24.
MooreRYCardJP.Neuropeptide Y in the circadian timing system.
In:
AllenJMKoenigJI,
Central and peripheral significance of neuropeptide Y and its related peptides.
Ann NY Acad Sci1990;
611:
247–57
25.
InouyeSITShinokaraKTominagaKTakeuchiJNagasakiHIsobeYCircadian rhythms in peptides and their precursor messenger RNAs in the suprachiasmatic nucleus.
In:
NakagawaHOomuraYNagaiK,
New functional aspects of the suprachiasmatic nucleus of the hypothalamus.
London:
J Libbey,
1993:
219–33
26.
BrayGASakaguchiTYoshidaT.The suprachiasmatic and ventromedial nucleus: sympathetic activity and food intake are reciprocally related.
In:
NakagawaHOomuraYNagaiK,
New functional aspects of the suprachiasmatic nucleus of the hypothalamus.
London:
J Libbey1993:
61–74
MooreRYCardP.Visual afferents and suprachiasmatic nucleus pacemaker function.
In:
NakagawaHOomuraJNagaiK,
New functional aspects of the suprachiasmatic nucleus of the hypothalamus.
London:
J Libbey,
1996:
1–13
29.
SwansonLWCanterasNSWattsAG.Organization of supra chiasmatic inputs to forebrain circuitry.
In:
NakagawaHOomuraJNagaiK,
New functional aspects of the suprachiasmatic nucleus of the hypothalamus.
London:
J Libbey,
1993:
35–42
30.
OkamuraHKawakamiFTamadaYGeffardMNishiwakiTIbataYInouyeST.Circadian change of VIP mRNA in the rat suprachiasmatic nucleus following p-chlorophenylalanine (PCPA) treatment in constant darkness.
Brain Res Mol Brain Res1995;
29
(2):
358–64
31.
CardJPMooreRY.Identification of retinorecipient neurons by transneuronal transport of alpha herpes virus.
In:
NakagawaHOomuraYNagaiK,
New functional aspects of the suprachiasmatic nucleus of the hypothalamus.
London:
J Libbey,
1993:
15–25
32.
CassoneVMWarrenWSBrooksDSLuJ.Melator in, the pineal gland, and circadian rhythms.
J Biol Rhythms1993;
8Suppl 8:
73–81
33.
JanJEEspezelHAppletonRE.The treatment of sleep disorders with melatonin.
Dev Med Child Neurol1994;
36:
97–107
34.
ShiotaniY.The suprachiasmatic nucleus and the pinea gland.
In:
NakagawaHOomuraYNagaiK,
New functional aspects of the suprachiasmatic nucleus of the hypothalamus.
London:
J Libbey,
1993:
235–9
35.
ReppertSMWeaverDRRivkeesSAStopaEG.Futative melatonin receptors in a human biological clock.
Science1988;
242:
78–81
36.
ReppertSMGodsonCMahleCDWeaverDRSlauge thauptSAGusellaJF.Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mellb melatonin receptor.
Proc Natl Acad Sci USA1995;
92:
8:
34–8
37.
OkataniYSagaraY.Enhanced nocturnal melatonin secretion in women with functional secondary amenorrhea: relationship to opioid system and endogenous estrogen levels.
Horm Res1995;
43:
194–9
38.
TouitouY.Effects of ageing on endocrine and neuroendocrine rhythms in humans.
Horm Res1995;
43:
12–9
39.
WaldhauserFWeiszenbacherGZeitlhuberUWaldhauserMWurtmanJR.Fall in nocturnal serum melatonin during pre-puberty and pubescence.
Lancet1984;
i:
362–5
40.
WetterbergLArendtJPaunierLSizonenkoPCDonsellarVWHeydenT.Human serum melatonin changes during the menstrual cycle.
J Clin Endocrinol Metab1976;
42:
185–8
41.
WebleyGELeidenbergerF.The circadian pattern of melatonin and its positive relationship with progesterone in women.
J Clin Endocrinol Metab1986;
63:
323–8
42.
ProsserRAHellerHCMillerJD.Serotonergic phase advances of the mammalian circadian clock involve protein kinase A and K+ channel opening.
Brain Res1994;
64
(1):
67–73
43.
CarlssonASvennerholmLWinbladB.Seasonal and circadian monoamine variations in human brains examined post mortem.
Acta Psychiatr Scand1980;
61Suppl 280:
75–86
44.
LeibowitzSF.Diurnal rhythms in neurochemical neuroendocrine systems controlling nutrient intake and energy metabolism.
In:
NakagawaHOomuraYNagaiK,
New functional aspects of the suprachiasmatic nucleus of the hypothalamus.
London:
J Libbey,
1993:
59–67
45.
FerrariMDSaxenaPR.On serotonin and migraine: a clinical and pharmacological review.
Cephalalgia1993;
13:
151–65
46.
SamaninRGarattiniS.Serotonin and the pharmacology of eating disorders.
In:
SchneiderLHCooperSJHalmiKA,
The psychobiology of human eating disorders.
Ann N Y Acad Sci1989;
575:
194–207
47.
BrewertonTMullerEBrandtH.LesemMHeggAMurphyDJimersonD.Dysregulation of 5HT function in bulimia nervosa.
In:
SchneiderLHCooperSJHalmiKA,
The psychobiology of human eating disorders.
Ann NY Acad Sci1989;
575:
500–2
48.
FornariVSandbergDELachenmeyerJCohenDMatthewsMMonteroG.Seasonal variations in bulimia nervosa.
In:
SchneiderLHCooperSJHalmiKA,
The psychobiology of human eating disorders.
Ann NY Acad Sci1989;
575:
509–11
49.
RogackiNWeissGFFuegASuhJSPalSStanleyBGImpact of hypothalamic serotonin on macronutrient intake.
In:
SchneiderLHCooperSJHalmiKA,
The psychobiology of human eating disorders.
Ann NY Acad Sci1989;
575:
619–21
50.
SteffensABStrubbeJHScheurinkAJW.Circadian rhythmicity in autonomic nervous system functioning.
In:
NakagawaHOomuraYNagaiK,
New functional aspects of the suprachiasmatic nucleus of the hypothalamus.
London:
J Libbey,
1993:
241–7
51.
RuggieroDAFeinsteinDL.The autonomic nervous system.
In:
MraovitchSSercombeR,
In:
Neurophysiological basis of cerebral blood flow control: an introduction.
London:
J Libbey1993:
1–46
52.
LydicRSchoeneWCCzeislerCAMoore-EdeMC.Supra-chiasmatic region of the human hypothalamus: homolog to the primate circadian pacemaker?.
Sleep1980;
2
(3):
355–61
53.
CohenRAAlbersHE.Disruption of human circadian and cognitive regulation following a discrete hypothalamic lesion: a case study.
Neurology1991;
41:
726–9
54.
SchwartzWJBusisNAHedley-WhyteET.A discrete lesion of ventral hypothalamus and optic chiasm that disturbed the daily temperature rhythm.
J Neurol1986;
233:
1–4
WilkinsonM.Clinical features of migraine.
In:
VinkenPJBruynGWRoseFC,
Handbook of clinical neurology, vol. 4(48): Headache.
Amsterdam:
Elsevier,
1986:
117–33
57.
NappiG.Hormone changes in headache disorders.
Megrim1994;
12:
12–4
58.
BilleB.Migraine in school children.
Acta Paediatr Scand1962;
51Suppl 136:
1–151
59.
McGregorEA.“Menstrual” migraine: towards a definition.
Cephalalgia1996;
16:
11–21
60.
SahotaPKDexterJD.Sleep and headache syndromes: a clinical review.
Headache1990;
30:
80–4
61.
SolomonGD.Circadian variation in the frequency of headache.
Megrim1994;
12:
6–7
62.
GoadsbyPJ.Migraine, autonomic dysfunction and the physiology of the cerebral vessels.
In:
MraovitchSSercombeR,
Neurophysiological basis of cerebral blood flow control: an introduction.
London:
J Libbey,
1996:
376–83
63.
SicuteriFNicolodiM.Redundant pain transmission from functional deafferentation.
In:
RoseFC,
Advances in headache research.
London:
J Libbey,
1987:
11–18
64.
LeaoAAP.Spreading depression of activity in cerebral cortex.
J Neurophysiol1944;
7:
359–90
65.
LeaoAAP.On the inferred relationship of migraine and spreading depression.
In:
RoseFC,
London:
J Libbey,
1987:
19–24
66.
OlesenJLarsenBLauritzenM.Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine attacks.
Ann Neurol1981;
9:
344–52
67.
SimkinsRTTepleyNBarkleyGLWelchKMA.Spontaneous neuromagnetic fields in migraine: possible link to spreading cortical depression.
Neurology1989;
39Suppl 1:
325
68.
LauritzenM.Pathophysiology of the migraine aura. The spreading depression theory.
Brain1994;
117
(Pt 1):
199–210
69.
WelchKMBarkleyGLTepleyNRamadanNM.Central neurogenic mechanism of migraine.
Neurology1993;
436Suppl 3:
S21–5
70.
KaubeHGoadsbyPJ.Anti-migraine compounds fail to modulate the propagation of cortical spreading depression in the cat.
Eur Neurol1994;
34:
30–5
