The effects of aspirin on the contingent negative variation (CNV) of 16 healthy, right-handed volunteers were studied in accordance with a placebo-controlled double-blind crossover design. Early and late CNV factors were measured. Aspirin caused a statistically significant decrease of the early wave and an increase of mean amplitude of the late wave. A central action of aspirin, affecting noradrenergic and dopaminergic structures, may be responsible for the CNV changes.
WalterWGCooperRAldridgeVJMcCallumWCWinterALContingent negative variation: an electric sign of sensorimotor association and expectancy in the human brain.Nature (Lond)1964;203:360–94
2.
Timsit-BerthierMLes potentiels lents lies aux eveniments.Rev EEG Neurophysiol1976;6:181–5
3.
Timsit-BerthierMApropos de l'interpretation de la variation contingente negative en psychiatrie.Rev EEG Neurophysiol1981;11:236–44
4.
SchoenenJTimsit-BerthierMContingent negative variation: methods and potential interest in headache.Cephalalgia1993;13:28–32
5.
SchoenenJMaertensATimsit-BerthierMTimsitMContingent negative variation (CNV) as diagnostic and physiopathologic tool in headache patients. In:CliffordRose, editor.Migraine. Proc 5th Int Migraine Symp, London 1984. Basel: Karger,1985;17–25
6.
Maertens de NoordhoutATimsit-BerthierMTimsitMSchoenenJContingent negative variation in headache.Ann Neurol1986;19:78–80
7.
Nagel-LeibySWelchKMAD'AndreaGGrunfeldSBrownEEvent-related slow potentials and associated catecholamine function in migraine.Cephalalgia1990;10:317–29
8.
MunteTFHeinzeHJKunkelHUse of endogenous event-related potentials (ERP) in the evaluation of psychotropic substances: towards an ERP profile of drug effects.Neuropsychobiology1986;16:135–45
9.
SchoenenJMaertens de NoordhoutATimsit-BerthierMTimsitMContingent negative variation and efficacy of beta-blocking agents in migraine.Cephalalgia1986;6:229–33
10.
Maertens de NoordhoutATimsit-BerthierMTimsitMSchoenenJEffects of beta-blockade on contingent negative variation in migraine.Ann Neurol1987;21:111–2
11.
SchoenenJBeta-blockers and the central nervous system.Cephalalgia1986:6Suppl 5:47–54
12.
DaviesPTGClifford RoseFThe effect of aspirin in headaches and migraine. In:VaneJRBottingRM, editor.Aspirin and other salicylates.London, New York, Tokyo:Chapman & Hall1992;373–94
13.
VaneJRBottingRMAnalgesic action of aspirin. In:VaneJRBottingRM, editor.Aspirin and other salicylates.London, New York, Tokyo:Chapman & Hall1992;166–212
14.
ShyuKWLinMTWuTCCentral serotoninergic neurons: their possible role in the development of dental pain and aspirin-induced analgesia in monkeys.Exp Neurol1984:84;179–87
15.
ShyuKWLinMTHypothalamic monoaminergic mechanisms of aspirin-induced analgesia in monkeys.J Neural Transm1985;62:285–93
16.
HiguchiSTanakaNShioiriYTwo modes of analgesic action of aspirin, and the site of analgesic action of salicylic acid.Int J Tissue React1986:8;327–31
17.
GöbelHErnstMJeschkeJKeilRWeigleLAcetylsalicylic acid activates antinociceptive brain stem reflex activity in headache patients and in healthy subjects.Pain1992;48:187–96
18.
BrommBRundshaugenISchreinECentral analgesic effects of acetylsalicylic acid in healthy men.Arzneimittelferschung1991;41:1123–9
19.
CataniaAArnoldJMacalusoAInhibition of acute inflammation in the periphery by central action of salicylates.Proc Nail Acad Sci USA1991;88:8544–7
20.
PilettaPPorchetHCDayeaPCentral analgesic effect of acetominophen but not of aspirin.Clin Pharmacol Ther1991;49:350–4
21.
Timsit-BerthierMGeronoARousseauJCMantanusHAbrahamPVerheyFAn international pilot study of CNV in mental illness. Second report.Ann NY Acad Sci1984;71–7
22.
KroppPGerberW-DIs increased amplitude of contingent negative variation in migraine due to cortical hyperactivity or to reduced habituation?Cephalalgia1993;13:37–41
23.
BockerKBETimsit-BerthierMSchoenenJBruniaCHMContingent negative variation in migraine.Headache1990;30:604–9
24.
LanceJWLambertGAGoadsbyPJZagamiASContribution of experimental studies to understanding the pathophysiology of migraine. In:SandlerMCollinsG, editors.Migraine. A spectrum of ideas.Oxford:Oxford University Press,1990:21–36
25.
CyioriniJRSlow potential changes from cat cortex and classical aversive conditioning.Electroencephalogr Clin Neurophysiol1969;26:399–406
26.
BordaRPThe effect of altered drive states on the contingent negative variation (CNV) in rhesus monkeys.Electroencephalogr Clin Neurophysiol1970;29:173–80
27.
YinglingCDSkinnerJEGating of thalamic input to cerebral cortex by nucleus reticularis thalami. In:DesmedtJR, editor.Progress in clinical neurophysiology. Vol. 1: Attention, voluntary contraction and event-related cerebral potentials.New York:Karger,1977:70–96
28.
KroppPGerberW-DContingent negative variation- findings and perspectives in migraine.Cephalalgia1993;13:33–6
29.
GroppettiABragaPCBiellaGEffect of aspirin on serotonin and met-enkephalin in brain: correlation with the antinociceptive activity of the drug.1988;27:499–505
