We measured serum interleukin-I beta (IL-1 beta) in 24 episodic cluster headache (CH) patients and 45 normal controls using a specific ELISA method. There was an increase in IL-1 beta in all CH patients compared to controls. IL-1 beta was further increased during the ictal phase of CH compared to patients between attacks and normal individuals. Between attacks, IL-1 beta was also significantly increased compared to controls. We suggest that these results represent an activation of the immune system in CH.
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References
1.
MartellettiPAdrianiEBoniniSCelestinoDLentiLArmaleoCDi PastenaAMisasiRGiacovazzoMBasophil histamine release and leukotriene (LTB4--LTC4) production in cluster headache.Headache1989;29:46–9
2.
MartellettiPAlteriEPesceARinaldi-GaraciCGiacovazzoMDefect of serotonin binding to mononuclear cells from episodic cluster headache patients.Headache1987;27:23–6
3.
MartellettiPStirparoGDe StefanoLDi SabatoFGiacovazzoMRinaldi-GaraciCDefective expression of IL-2 receptors on peripheral blood lymphocytes from patients with cluster headache.Headache1990;30:228–31
4.
StirparoGMartellettiPMorroneSSavareseAGiacovazzoMImpaired natural killer activity in PBLs from cluster headache patients is restored by interleukin 2.Int J Immunotherapy1990;6:181–6
5.
MartellettiPStirparoGDe StefanoLRinaldi-GaraciCGiacovazzoMStudies on lymphokine-activated killer cells and natural killer cells in cluster headache: increased sensitivity to RIL-2 and IFN-B. In:Clifford Rose edNew advances in headache research.London:Smith Gordon,1989:139–44
6.
Headache Classification Committee of the International Headache Society:classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain.Cephalalgia1988;8(suppl 7):1–96
7.
Rordorf-AdamCLazdinsJWoods-CookKAlteriEHennRGeigerTFeigeUTowbinHErardFAn assay for the detection of interleukin-1 synthesis inhibitors: effects of antirheumatic drugs.Drugs Exptl Clin Res1989;15:355–62
8.
DinarelloCInterleukin 1: amino acid sequences, multiple biological activities and comparison with tumor necrosis factor (cachectin).Year Immunol1986;2:68–71
9.
FarrarWLKilianPLRuffMRHillJMPertCBVisualization and characterization of interleukin-1 receptor in the brain.J Immunol1987;139:459–63
10.
GiulianDLachmanLBInterleukin-1 stimulation of astroglial proliferation after brain injury.Science1985;228:497–9
11.
GalloPFreiKRordorf-AdamCLazdinsJTavolatoBFontanaAHuman immunodeficiency virus type-1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid.J Neuroimmunology1989;23:109–16
12.
StirparoGMartellettiPDe StefanoLGiacovazzoMRinaldi-GaraciCIL-2 induces PHA proliferation in peripheral blood mononuclear cells from cluster headache patients.Cephalalgia1991;11(suppl 11):270–1
13.
MartellettiPStirparoGDe StefanoLBonmassarEGiacovazzoMReduced activity of the NK cells from patients with cluster headache and the “in vitro” response to beta-IFN.Headache1987;27:548–51
14.
DunnAJInterleukin-1 as a stimulator of hormone secretion.PNEI1990;3:26–31
15.
WeigentDACarrDJJBlalockJEBidirectional communication between the neuroendocrine and immune systems.Ann NY Acad Sci1990;579:1340–51
16.
SharpBMMattaSGPetersonPKNewtonRChaoCMcAllenKTumor necrosis factor-alpha is a potent ACTH secretagogue: comparison to interleukin-beta.Endocrinology1989;124:3131–6
17.
HardeboJEThe involvement of trigeminal substance P in cluster headache. An hypothesis.Headache1984;24:294–304
18.
FanciullacciMFuscoBMAlessandriVCampagnoloVSicuteriFUnilateral impairment of pupillary response to trigeminal nerve stimulation in cluster headache.Pain1989;36:185–9
19.
SicuteriFFanciullacciMGeppettiPNicolodiMFuscoBMMarabiniSAlessandriMCampagnoloVSubstance P theory, a unicus focus on the pathogenesis of cluster headache.Headache1990;30:145–54
20.
LotzMVaughanJHCarsonDAEffect of neuropeptides on production of inflammatory cytokines by human monocytes.Science1988;241:1218–21
21.
RothwellNJFunctions and mechanisms of interleukin I in the brain.TIPS1991;12:430–6
22.
FerreiraSHLorenzettiBBBristowAFPooleSInterleukin-1 beta as a potent agent antagonized by a tripeptide analogue.Nature1988;334:698–700
23.
LonnemanGEndresSVan der MeerJWCannonJGKochKMDinarelloCADifferences in the synthesis and kinetics of release of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor from human mononuclear cells.Eur J Immunol1989;19:1531–6
