Flunarizine was tested for prophylactic efficacy and for side effects in 10- to 13-year-old patients with severe migraine (> 2 attacks per month). The 13 preadolescents received a single 5-mg dose at night for 2 months. The attack frequency decreased significantly, and the effect was maintained over time. The endocrine status, investigated before and after treatment, showed no significant interference with pituitary, beta-pancreatic, or gonadal function.
AmeryWKFlunarizine a calcium channel blocker: a new prophylactic drug in migraine.Headache1983; 23: 70–4
2.
SörensenSHansenKOlesenJFlunarizine in common migraine prophylaxis. A double blind cross-over study.Cephalalgia1985; 5(suppl 3): 540–1
3.
CentonzeVAttoliniSMacinagrossaGCam-panozziFMagroneDTesaroPLoysyCAlbonoO5 mg flunarizine in preventive therapy of migraine: efficacy and tolerance. Cephalalgia1985; 5(suppl 3): 5367
4.
SorgeFDe SimoneRMaranoSOreficeGCarrieriPEfficacy of flunarizine in the prophylaxis of migraine in children: a double blind, cross-over, controlled study.Cephalalgia1985; 5
(suppl 3): 172
5.
CortelliPSantucciMRighettiFPirazzoliPAlboniFBoldratiADe CarolisPBaruzziASacquegnaTCacciariEHormonal and metabolic changes induced by flunarizine therapy.Cephalalgia1985; 5(suppl 3): 358–9
6.
Ad Hoc Committee on Classification of Headache of the NIH. JAMA1962; 179: 7178
7.
NelsonWBTextbook of pediatrics. 12th ednPhiladelphia: WB Saunders1983: 140
8.
National Heart, Lung and Blood Institute. Recommendations of the task force on blood pressure control in children. Pediatrics1977; 59
(suppl): 797820
9.
YalowRSBersonSAImmunoassays of endogenous plasma insulin in man. J Clin Invest1960; 39: 115760
10.
RatleAJSPunnellDRWilliamPIMSidleKForrestJCNew separation method for monoclonal immunoradiometric assays for tyrothropin human corion haemotrophic.Clin Chem1984; 30(9): 1457–61
11.
RotaGFerlinGDosaggi radioimmunologici nella pratica clinica. Standardizzazione di parametri operativi.Sorin Biomed Torino1979; 27–36
12.
SchnekAGSchoroedeWTest combination HBA1.J Am Chem Soc1961; 83: 1472–8
13.
MalvenoRRosaVCurrent status of standardization of steroid radioimmunoassay.J Nucl Biol Med1972; 16: 90–101
14.
BonoGManzoniGCMartucciNSacquegnaTMicieliGNappiGAgnoliAFlunarizine treatment in migraine syndrome: long term follow-up in common migraine and preliminary results in migraine with interparoxismal headache.Cephalalgia1985; 5(suppl 2): 538–9
15.
NappiGMartignoniGFlunarizina e depressione.G Neuropsicofarmacol1986; 1: 5
16.
GovoniSTrabucchiMMagnoniMSBattainiFPaolettiRAbnormal neurotransmitter release and calcium entry blockers. In:GodfraindT, eds Calcium entry blockers and tissue protection. New York: Raven Press1985: 15162
17.
GuidettiVLa terapia delle cefalee in etá evolutiva.Pediatria Oggi1986; 6: 211–21
18.
PrenskyALDodgePRBarlowCFFrenchJJohnsonSDRossDLDisorders of the hypothalamus and pituitary gland in adolescence and childhood. In:SwaimanKFWrightFS eds. The practice of pediatric neurology. St Louis: C V Mosby1982; 1: 632–47
19.
HockadayJMManagement of migraine in children. In:CarrollJDPfaffenrathVSjaastadO, eds. Migraine and beta-blockade. Uddevalla, Sweden: Bohusläningens Boktryckeri AB Press1985: 22832
20.
SillsMCongdonPForsytheIClonidine and childhood migraine: a pilot and double-blind study.Dev Med Child Neurol1982; 24: 837–41
21.
ForsytheWIGilliesDSillisMAPropanolol (Inderal) in the treatment of childhood migraine.Dev Med Child Neurol1984; 26: 737–41
