In a randomized, double-blind cross-over study, 43 patients with classic migraine received 40 mg Nimodipine and placebo as sublingual capsules. There was no significant effect on patients' preference, development of headache, need for escape medicine, duration of headache, severity of headache or headache index. Considerable methodological problems were encountered. Only 54% of the 79 patients selected for the trial could be evaluated. Suggestions for future trials are made.
TowartR.The selective inhibition of serotonin-induced contractions of rabbit cerebral vascular smooth muscle by calcium antagonistic dihydropyridines. An investigation of the mechanism of action of Nimodipine.Circ Res1981;5:650–7.
2.
TowartRWehingerEMeyerHKazdaS.The effects of Nimodipine, its optical isomers and metabolites on isolated vascular smooth muscle.Arzneim-Forsch/Drug Res1982;4:338–46.
3.
WhiteRPCunninghamMPRobertsonJT.Effect of the calcium antagonist Nimodipine on contractile responses of isolated canine basilar arteries induced by serotonin, prostaglandin F2alfa, thrombin, and whole blood.Neurosurg1982;3:344–8.
4.
SteenPANewbergLAMildeJHMichenfelderJD.Nimodipine improves cerebral blood flow and neurologic recovery after complete cerebral ischemia in the dog.J Cereb Blood Flow Metabol1983;1:38–43.
5.
Havanka-KanniainenHMyllylaeVHokkanenE.Nimodipine-a selective calcium antagonist-in the prevention of migraine.Abstract at 1st International Headache Congress1983,Munich.
6.
AuerLMItoZSuzukiAOhtaH.Prevention of symptomatic vasospasm by topically applied Nimodipine.Acta Neurochir1982;63:297–302.
7.
AllenGS, et al.Cerebral arterial spasm-a controlled trial of Nimodipine in patients with subarachnoid hemorrhage.New Engl J Med1983;11:61–24.
8.
Ad Hoc Committee on Classification of Headache of the National Institute of Health.Jama1962;2:717–18.
9.
CohenJ.Statistical power analysis for the behavioral sciences.Rev ed.Academic Press,1977:150–75.
10.
Tfelt-HansenPOlesenJ.Effervescent metoclopramide and aspirin (Migravess) versus effervescent aspirin or placebo for migraine attacks: A double blind study.Cephalalgia1984;2:107–11.
11.
RaemschKDScherlingDBuhnerKSommerJ.Pharmacokinetics and metabolism of Nimodipine.Abstract at the First International Nimotop (R) Symposium. Munich1984.
12.
NimodipineGelmers HJ.A new calcium antagonist in the prophylactic treatment of migraine.Headache1983;3:106–9.
13.
MeyerJSHardenbergJ.Clinical effectiveness of calcium entry blockers in prophylactic treatment of migraine and cluster headache.Headache1983;23:266–77.
