Given the widespread use of caffeine and its potential nonoptimal effects during pregnancy, it is remarkable and distressing that almost nothing is known about the long-term effects of prenatal caffeine exposure in humans. Research on nonhumans reveals that prenatal caffeine exposure is associated with an enduring tendency toward a profile of fearfulness, hypoactivity, and exaggerated stress in uncertain situations. A similar pattern of behavioral inhibition has been observed in humans and has been attributed to various causes such as inborn temperament or environmental influences. The author's conjecture is that prenatal caffeine exposure could be an additional factor contributing to the tendency toward behavioral inhibition. One mechanism for this effect is that caffeine causes an upregulation of adenosine receptors, thus creating a vulnerability to adenosine-induced inhibition of neuronal firing and neurotransmitter release.
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