Background
High altitude exposure is increasing owing to the constantly rising numbers of mountaineers and trekkers, and it is a clinically relevant cause of complex pathophysiological events leading to alterations in all parts of the body, including the visual system. Previous reports on intraocular pressure (IOP) changes during high altitude exposure have provided inconsistent and even conflicting results.
Objective
The purpose of our study was to investigate the effect of acute high altitude exposure on IOP using state-of-the-art Goldmann applanation tonometry and to assess a correlation with AMS and vital parameters.
Methods
Fourteen healthy lowlanders ascended from Tübingen, Germany (341 m), to the Capanna Margherita, Italy (4559 m), during the Tübingen High Altitude Ophthalmology research study within 24 hours, including 1 overnight stay at 3647 m. The IOP measurements using a Goldmann tonometer (Haag-Streit, Switzerland) and AMS scores (Lake Louise and AMS-c scores) were assessed twice daily; oxygen saturation (Sp
Results
The IOP was decreased on day 2 by an average of −0.57 mm Hg (mean intraindividual difference; 95% CI: −1.71 to 0.56 mm Hg) and remained decreased during high altitude exposure; all values were statistically not significant compared with baseline. Incidence of AMS according to AMS scores was 50% on day 2. Subjects with AMS had lower Sp
Conclusions
No significant change of IOP was noted during high altitude exposure over 4 days spent at high altitude compared with baseline. However, a tendency for a decreased IOP during high altitude exposure was noted. No correlation between IOP and AMS scores or clinical parameters was observed.