Abstract
Objectives
Increase in serum insulin-like growth factor-1(IGF-1)level is one of the proposed mechanisms for growth improvement after adenotonsillectomy, but time period for this increase is unclear. This study was conducted to determine the effect of adenotonsillectomy on serum IGF1 level in early postoperative period.
Methods
Children 3 to 10 years of age who underwent adenotonsillectomy because of upper airway obstruction entered the study; weight and height were recorded at the time of surgery. Serum IGF-1 level was measured before and 3 weeks after surgery. Wilcoxon test was used for comparison of preoperative and postoperative IGF-1 levels.
Results
The study population included 14 boys and 9 girls with the mean age of 6.74±1.76 years. Serum IGF-1 levels increased significantly (p<0.001)from 159.08± 79.83 ng/ml before adenotonsillectomy to 252.26± 131.17 ng/ml three weeks after surgery. All patients (3 girls and 3 boys) with serum levels below normal range had normal values 3 weeks after surgery.
Conclusions
This study showed that the effect of adenotonsillectomy on growth improvement based on hormonal factor is initiated in early stage after surgery.
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