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Abstract

Objectives

To compare urinary leukotriene E4 (ULT) level in patients with nasal polyposis (NP) with and without aspirin intolerance and allergic rhinitis (AR), and correlate it with disease severity.

Study Design and Setting

Prospective study from November 2005 to November 2006. Patients with NP (n = 30) and AR (n = 35) were included. The concentration of ULT was measured in both groups. Oral provocation test with aspirin was performed to patients with NP. ULT level between both groups was compared and correlated with NP disease severity.

Results

ULT concentration was elevated on NP and AR. The patients with NP and aspirin intolerance (n = 4) presented higher levels of ULT compared to aspirin-tolerant patients. Leukotriene concentration was not correlated with NP severity.

Conclusions

Patients with NP and aspirin intolerance have increased ULT excretion; thus their measurement can be used as an indicator of arachidonic acid metabolism alteration.

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References

Hedman

Kaprio

Poussa

Prevalence of asthma, aspirin intolerance and chronic obstructive pulmonary disease in a population based study. Int J Epidemiol 1999; 28:717–22.

Spada

Nieves

Krauss

Comparison of leukotriene B4 and D4 effects on human eosinophil and neutrophil motility in vitro.

J Leukoc Biol 1994; 55(2):183–91.

Pedersen

Bochner

Undem

BJ.

Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. J Pharmacol Exp Ther 1997; 281:655–62.

O'Byrne

PM.

Leukotrienes in the pathogenesis of asthma [Review].

Chest 1997; 111(2 Suppl):27S–34S.

Naclerio

Baroody

Togias

AG.

The role of leukotrienes in allergic rhinitis: a review.

Am Rev Respir Dis 1991; 143(5 Pt 2):S91–5.

Donnelly

Glass

Minkwitz

The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis. Am J Respir Crit Care Med 1995; 151:1734–9.

Steinke

Bradley

Arango

Cysteinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: importance to eosinophilia and asthma. J Allergy Clin Immunol 2003; 111:342–9.

Sampson

Siddiqui

Buchanan

Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast.

Thorax 2000; 55(Suppl 2): S28–31.

Cook

The role of aspirin sensitivity and nasal polyposis. Curr Opin Otolaryngol Head Neck Surg 2002; 10:213–6.

10.

Samter

Beers

Jr.

Intolerance to aspirin. Clinical studies and consideration of its pathogenesis. Ann Intern Med 1968; 68:975–83.

11.

Gosepath

Mann

Aspirin intolerance and nasal polyps. Curr Opin Otolaryngol Head Neck Surg 2002; 10:3–7.

12.

Higashi

Taniguchi

Mita

Clinical features of asthmatic patients with increased urinary leukotriene E4 excretion (hyperleukotrienuria): involvement of chronic hyperplastic rhinosinusitis with nasal polyposis. J Allergy Clin Immunol 2004; 113:277–83.

13.

Micheletto

Visconti

Tognella

Aspirin induced asthma (AIA) with nasal polyps has the highest basal LTE4 excretion: a study vs AIA without polyps, mild topic asthma, and normal controls.

Allerg Immunol (Paris) 2006; 38(1):20–3.

14.

Manning

Rokach

Malo

Urinary leukotriene E4 levels during early and late asthmatic responses. J Allergy Clin Immunol 1990; 86:211–20.

15.

Lund

Kennedy

DW.

Staging for rhinosinusitis.

Otolaryngol Head Neck Surg 1997; 117(3 Pt 2):S35–40.

16.

Lund

Kennedy

DW.

Quantification for staging sinusitis. The Staging and Therapy Group. Ann Otol Rhinol Laryngol Suppl 1995; 167:17–21.

17.

Swierczynska

Nizankowska-Mogilnicka

Zarychta

Nasal versus bronchial and nasal response to oral aspirin challenge: Clinical and biochemical differences between patients with aspirin-induced asthma/rhinitis. J Allergy Clin Immunol 2003; 112:995–1001.

18.

Bateman

Fahy

Woolford

TJ.

Nasal polyps: still more questions than answers. J Laryngol Otol 2003; 117:1–9.

19.

Ragab

Parikh

Darby

An open audit of montelukast, a leukotriene receptor antagonist, in nasal polyposis associated with asthma. Clin Exp Allergy 2001; 31:1385–91.

20.

Grundmann

Topfner

Treatment of ASS-Associated Polyposis (ASSAP) with a cysteinyl leukotriene receptor antagonist—a prospective drug study on its antiinflammatory effects. Laryngorhinootologie 2001; 80:576–82.

Urinary leukotrienes in patients with nasal polyposis