OBJECTIVE: The present study was undertaken to investigate the expressions of glucocorticoid receptor-α (GR-α) and -β (GR-β) messenger RNA (mRNA) in normal parotid and adenoma tissues.
STUDY DESIGN AND SETTING: Eighteen pleomorphic adenomas of the parotid gland and 12 parotid gland tissues adjacent to adenomas were studied by using real-time fluorescent quantitative reverse-transcription polymerase chain reaction method.
RESULTS: The expression of both GR-α and GR-β mRNA in parotid adenoma were higher than that in normal parotid glands (P < 0.001), the GR-α/GR-β ratios in parotid adenoma were lower than that in normal parotid glands (P < 0.001), and there were no differences of both GR-α and GR-β mRNA as well as GR-α/GR-β ratios in male and female (P > 0.05).
CONCLUSION AND SIGNIFICANCE: Our results showed that the mRNA expression of both GR-α and GR-β were detectable in all studied specimens. The mRNA levels of these 2 GRs were higher, whereas the GR-α/GR-β ratios were lower in adenomas tissues than that in the parotid gland; no differences of these 2 GRs as well as GR-α/GR-β ratios were found between sexes. These data indicate that the relationship between the expressions of GRs and the clinical significance in parotid adenomas need further and profound investigation.
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