Nasal polyp diseases in allergic and nonallergic patients and steroid therapy

Abstract

Objective

To investigate widespread disease causes, cellular-structural differences, and steroid response of nasal polyps (NPs).

Method

Study group consisted of NPs, allergic-NPs, NPs with steroid therapy (ST), antrochoanal polyp (ACP), and controls. We investigated stromal eosinophil, mast cell, CD4⁺ and CD8⁺ cell counts and presence of squamous metaplasia, Ki-67 expression, intraepithelial eosinophils-mast cells, epithelial damage, edema, fibrosis, hyalinization, polymorphonuclear leukocyte, and glandular hyperplasia.

Results

In allergic-NPs, intraepithelial eosinophils and epithelial damage CD4⁺ were significantly higher than NPs and also, eosinophils, mast cells, intraepithelial eosinophils, and epithelial damage were significantly higher than ACP. Only stromal eosinophilic infiltration was significantly higher in NPs than ACP. There was significant increased glandular hyperplasia and decreased intraepithelial eosinophils, mast cells, CD4⁺ cells, squamous metaplasia, and epithelial damage with ST in allergic-NPs. There were no significant differences with ST in NPs.

Conclusion

NPs in allergic and nonallergic patients may differ in their histology and in their histologic responses to ST.

EBM rating: B-3b