OBJECTIVE: To determine the effect of intradermal and topical mitomycin C (MMC) on skin wound healing.
STUDY DESIGN/SETTING: A prospective, controlled study in a rat wound model performed in an academic medical center.
RESULTS: Intradermal and topical MMC application decreased wound integrity when compared with saline-treated animals at 1 week, 2 weeks, 1 month, and 6 months. Skin necrosis occurred in animals that received intradermal MMC. Hemotoxylin and eosin and immunohistochemical staining showed no consistent difference between treatment arms. Fibrosis and collagen deposition were reduced in MMC-treated wounds on trichrome staining.
CONCLUSIONS: MMC-treated wounds showed decreased wound strength compared with controls. Intradermal MMC can cause skin necrosis. Histologic findings did not always correspond with clinical data.
SIGNIFICANCE: The data suggest cautious use of MMC in clinical situations when wound breaking strength is critical.
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