OBJECTIVE: The aim of this study was to report the clinicopathological features of 18 epithelial tumors of the lacrimal gland treated in a single institution.
STUDY DESIGN AND SETTING: Clinical data and treatment were recorded and histological features reviewed.
RESULTS: Twelve tumors (66.7%) were adenoid cystic carcinoma (ACC), 5 (27.8%) pleomorphic adenoma (PA), and 1 (5.5%) carcinoma ex pleomorphic adenoma. All patients with ACC presented with advanced clinical stage, and most were treated by wide surgical resection followed by adjuvant radiotherapy. No recurrence was observed in 4 cases of ACC; however, 7 patients died from persistence of disease or by local and/or distant recurrence. All PA patients were successfully treated by surgical resection.
CONCLUSIONS: Epithelial lacrimal gland tumors are mainly PA and ACC, and malignancies are more common than benign tumors. Although ACC presented typically with advanced clinical stage, 33% of the patients survived without tumor recurrence or metastasis.
EBM rating: C-4
Get full access to this article
View all access options for this article.
References
1.
ShieldsJAShieldsCLScartozziR. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology2004;111:997–1008
2.
FontRLShannonLSBryanRG. Malignant epithelial tumors of the lacrimal glands. A clinicopathologic study of 21 cases. Arch Ophthalmol1998;116:613–6
3.
PaulinoAFGHuvosAG. Epithelial tumors of the lacrimal glands: A clinicopathologic study. Ann Diagn Pathol1999;3:199–204
4.
ChuoNPing-KuanKDryjaTP. Histopathological classification of 272 primary epithelial tumors of the lacrimal gland. Chin Med J1992;6:481–5
5.
McLeanIWBurnierMNZimmermanLE: Atlas of Tumor Pathology: Tumors of the Eye and Ocular Adnexa.Washington, DC; AFIP, 1994; p. 215–32
6.
EsmaeliBAhmadiMAYoussefA. Outcomes in patients with adenoid cystic carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg2004;20:22–6
7.
SobinLHWittekindCh. UICC TNM Classification of Malignant Tumors.6th ed.New York: John Wiley & Sons, Inc., 2002. p. 272
8.
VangveeravongSKatzSERootmanJ. Tumors arising in the palpebral lobe of the lacrimal gland. Ophthalmology1996;103:1606–12
9.
ShieldsCLShieldsJA. Review of lacrimal gland lesions. Trans Pa Acad Ophthalmol Otolaryngol1990;42:925–30
10.
WrightJERoseGEGarnerA. Primary malignant neoplasms of the lacrimal gland. Br J Ophthalmol1992;76:401–7
11.
FontRLGamelJW. Epithelial tumors of the lacrimal gland: An analysis of 265 cases. In:JakobiecFA, ed. Ocular and Adnexal Tumors.New York, NY: Aescolapius Publishers Inc; 1978. p. 787–805
12.
CatesCAMannersRMRoseGE. Pleomorphic adenoma of the lacrimal gland in a 10-year-old girl. Br J Ophthalmol2002;86:249–50
13.
BreceliJStim-KranjcBSkrbecM. Visual electrophysiology in children with tumors affecting the visual pathway. Case reports. Doc Ophthalmol2000;101:125–54
14.
FaktorovichEGCrawfordJBCharDH. Benign mixed tumor (pleomorphic adenoma) of the lacrimal gland in a 6-year-old boy. Am J Ophthalmol1996;122:446–7
15.
ChandrasekharJFarrDRWhearNM. Pleomorphic adenoma of the lacrimal gland: Case report. Br J Oral Maxillofac Surg2001;39:390–3
16.
SturgisCDSilvermanJFKennerdellJS. Fine-needle aspiration for the diagnosis of primary epithelial tumors of the lacrimal gland and ocular adnexa. Diagn Cytopathol2001;24:86–9
17.
PerzinKHJakobiecFALivolsiVA. Lacrimal gland malignant mixed tumors (carcinomas arising in benign mixed tumors): A clinicopathologic study. Cancer1980;45:2593–606
18.
OstrowskiMLFontRLHalpernJ. Clear cell epithelial-myoepithelial carcinoma arising in pleomorphic adenoma of the lacrimal gland. Ophthalmology1994;101:925–30
19.
FriedrichREBleckmannV. Adenoid cystic carcinoma of salivary and lacrimal gland origin: Localization, classification, clinical pathological correlation, treatment results and long-term follow-up control in 84 patients. Anticancer Res2003;23:931–40
20.
PolitoELeccisottiA. Epithelial malignancies of the lacrimal gland: Survival rates after extensive and conservative therapy. Ann Ophthalmol1993;25:422–26
21.
MeldrumMLTseDTBenedettoP. Neoadjuvant intracarotid CT for the treatment of advanced adenocystic carcinoma of the lacrimal gland. Arch Ophthalmol1998;116:315–21
22.
GamelJWFontRL. Adenoid cystic carcinoma of the lacrimal gland: The clinical significance of a basaloid histologic pattern. Hum Pathol1982;13:219–25
