This article gives an overview of what is known and unknown about the epidemiology, diagnosis, risk factors, prevention and treatment for osteoporosis in men.
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References
1.
MeltonL.J.III, AtkinsonE.J., O’ConnorM.K., et al.Bone density and fracture risk in men. J Bone Miner Res, 1998; 13:1915–1923.
2.
O’NeillT.W., FelsenbergD., VarlowJ., et al.The prevalence of vertebral deformity in European men and women: The European Vertebral Osteoporosis Study. J Bone Miner Res, 1996; 11:1010–1018.
3.
LauE.M.C., LeeJ.K., SuriwongpaisalP., et al.The incidence of hip fracture in four Asian countries. The Asian Osteoporosis Study (AOS). Osteoporos Int, 2001; 12:239–243.
4.
LauE.M.C., DonnanS.P.B., BarkerD.J.P.Hip fracture in Hong Kong and Britain. Int J Epidemiol, 1990; 19:1119–1121.
5.
LauE.M.C., ChanY.H., ChanM., et al.Vertebral deformity in Chinese men: prevalence, risk factors, bone mineral density and body composition measurements. Calcif Tissue Int, 2000; 66:47–52.
6.
LauE., ChanH., WooJ., et al.Normal ranges for and the prevalence of vertebral fracture in Hong Kong Chinese. J Bone Miner Res, 1996; 11:1364.
KanisJ.A.An update on the diagnosis of osteoporosis. Curr Rheumatol Rep, 2000; 2:62–66.
9.
ChengS., SuominenH., Sakari-RantalaR., et al.Calcaneal bone mineral density predicts fracture occurrence: a five-year follow-up study in elderly people. J Bone Miner Res, 1997; 12:1075–1082.
10.
KanisJ.A., JohnellO., AdenA., et al.Ten-year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds. J Bone Miner Res, 2001; 16:S194.
11.
OrwollE.Assessing bone density in men. J Bone Miner Res, 2000; 15:1867–1870.
12.
National Osteoporosis Foundation. Physicians guide to prevention and treatment of osteoporosis. 2003.
ClowesJA, EastellR. Markers of bone turnover and the laboratory evaluation of secondary osteoporosis. In: Osteoporosis: an evidence-based guide to prevention and management. Philadelphia: American College of Physicians; 2002.
15.
OrwollE., EttingerM., WeissS., et al.Alendronate for the treatment of osteoporosis in men. N Engl J Med, 2000; 343:604–610.
16.
RingeJ.D., FaberH., DorstA.Alendronate treatment of established primary osteoporosis in men; results of a 2-year prospective study. J Clin Endocrinol Metab, 2001; 86:5252–5255.
17.
SaagK.G., EmkeyR., SchnitzerT.J., et al.Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. Glucocorticoid-Induced Osteoporosis Intervention Study Group. N Engl J Med, 1998; 339:292–299.
18.
WallachS., CohenS., ReidD.M., et al.Effects of risedronate treatment on bone density and vertebral fracture in patients on corticosteroid therapy. Calcif Tissue Int, 2000; 67:277–285.
19.
AdachiJ.D., SaagK.G., DelmasP.D., et al.Two-year effects of alendronate on bone mineral density and vertebral fracture in patients receiving glucocorticoids: a randomized, double-blind, placebo-controlled extension trial. Arthritis Rheum, 2001; 44:202–211.
20.
SmithM.R., McGovernF.J., ZietmanA.L., et al.Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer. N Engl J Med, 2001; 345:948–955.
21.
OrwollE.S., OviattS.K., McClungM.R., et al.The rate of bone mineral loss in normal men and the effects of calcium and cholecalciferol supplementation. Ann Intern Med, 1990; 112:29–34.
22.
HeikinheimoR.J., InkovaaraJ.A., HarjuE.J., et al.Annual injection of Vitamin D and fractures of aged bones. Calcif Tissue Int, 1992; 51:105–110.
23.
AndersonF.H., FrancisR.M., FaulknerK.Androgen supplementation in eugonadal men with osteoporosis-effects of 6 months of treatment on bone mineral density and cardiovascular risk factors. Bone, 1996; 18:171–177.
24.
AndersonF.J., FrancisR.M., PeastonR.T., et al.Androgen supplementation in eugonadal men with osteoporosis: effects of six-months’ treatment on markers of bone formation and resorption. J Bone Miner Res, 1997; 12:472–478.
25.
BehreH.M., KlieschS., LeifkeE., et al.Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metab, 1997; 82:2386–2390.
26.
HamdyR.C., MooreS.W., WhalenK.E., et al.Nandrolone decanoate for men with osteoporosis. Am J Ther, 1998; 5:89–95.