Abstract
Activotec
P12 Accessory for Activo-P11
According to Activotec, the success of solid phase peptide synthesis using 9-fluorenylmethoxycarbonyl amino acids is often limited by deleterious side reactions that occur during TFA peptide–resin cleavage and side-chain deprotection. A majority of these side reactions modify susceptible residues, such as Trp, Tyr, Met, and Cys, with TFA-liberated side-chain protecting groups and linkers. The use of scavengers to suppress these side reactions is well established; however, common scavengers such as EDT and thioanisole are not best used in an open laboratory due to their noxious odor.
To overcome this problem, the new P12 cleavage device has been designed to directly accept the easily removed disposable reactor from the Activo-P11 peptide synthesizer. In this way, the Activo-P11 peptide synthesizer can be maintained in the open lab, whereas cleavage and deprotection procedures can be performed simply, speedily, and safely on the P12 in a fume hood.
For more information, visit www.activotec.com, e-mail
Adept Technology
Python Clean Room Class 1 ESD Modular Cartesian Robots
These new robots from Adept Technology are targeted at precision assembly and handling applications in the solar, disk drive, LCD, semiconductor, and life sciences markets. According to the company, they provide high speed and precision motion while maintaining very clean operation. The Adept Python modules can be configured to fit a wide range of ESD sensitive product applications. The Adept Python modules run on Adept's SmartControllerT CX controls and software platform.
For more information, visit www.adept.com.
Aspectrics
Application Note: Identification of Various Types of Edible Oils Using an Aspectrics MC2750 EP-NIR Spectrometer
A new application note from Aspectrics demonstrates the ability of its MultiComponent 2750 EP-NIR analyzer to achieve unequivocal identification of three different types of edible vegetal oils, without false positive response. Coupled to an external Aspectrics halogen NIR source and a Specac 2 mm path-length process transmission multimode fiber probe, the analyzer allows access to spectral information in the 2000–2600 nm range.
For more information, visit www.aspectrics.com.
Biodiesel Quality Analyzer 1000
Aspectrics extends its biodiesel portfolio with the new Aspectrics Biodiesel Quality Analyzer 1000 (BQA 1000), which incorporates the Aspectrics EP-NIR technology, a robust sampling interface, and an easy-to-use graphical user interface. In addition, the Aspectrics BQA 1000 is precalibrated for a number of biodiesel production applications. This comprehensive at-line system enables users to measure multiple points throughout the biodiesel production process, improving operations and maximizing yields. Providing quick and reliable analyses, the BQA 1000 delivers results in seconds. The integrated sampling interface simplifies analyses for at-line operation. In addition, the new graphical interface provides ease of operation and navigation, with real-time results displayed on the screen. Consequently, the analyzer is easy-to-use, training costs are reduced and there is no need for sample preparation.
For more information, visit www.aspectrics.com, e-mail
Beckman Coulter
nanoVette microliter accessory for DU 800 and DU 730 UV/Vis Spectrophotometers
According to Beckman Coulter, its new nanoVette microliter accessory for DU 800 and DU 730 UV/Vis spectrophotometers is ideal for DNA and protein applications. The cuvette-sized nanoVette accepts sample sizes as small as 0.7 μL, and is offered with interchangeable 0.2-mm and 1-mm path-length lids. Designed for precise fit in the Beckman Coulter spectrophotometers, the nanoVette can be loaded and cleaned without being removed from the instrument. The sample also can be recovered for future analysis.
For more information, visit www.beckmancoulter.com.
Optima MAX-XP Benchtop Ultracentrifuge
According to Beckman Coulter, the Optima MAX-XP benchtop ultracentrifuge delivers fast run times of up to 150,000 RPM (2500 revolutions per second) and is exceptionally quiet—producing only half the sound power of other benchtop models. A new MLA-150 fixed-angle rotor for the Optima MAX-XP has a low k-factor for rapid separation of small volume samples such as subcellular particles, viruses, and proteins.
The Optima MAX-XP features redesigned software with ease-of-use enhancements. The user interface is intuitive and customizable with control via a full-color touch screen. Optional remote monitoring and control of the system is also available. Users can easily switch between RPM and RCF modes. Important data, including detailed run histories, can be easily exported through a USB port. The software supports 21 CFR Part 11, GLP, and GMP compliance and new user ID and login features provide important lab management tools.
The Optima MAX-XP is offered with multiple levels of biocontainment and is designed to fit in a standard biosafety hood. For added protection, this new ultracentrifuge is also offered in a biosafe version featuring high-efficiency particle arresting filtration. A selection of labware and rotors for biosafety requirements is available and all existing Optima MAX and Optima TLX rotors are compatible with the new ultracentrifuge.
For more information, visit www.beckmancoulter.com.
BioTek
MicroFlow Select
According to BioTek, its new MicroFlo Select Dispenser offers superior microplate dispensing flexibility in one compact instrument, and is the first of its kind to offer a wide range of choices in dynamic dispense volumes, plate types, tube styles and sizes, automated dispense heights and cassettes to accommodate your dispensing requirements now and into the future.
The MicroFlo Select uses a specialized peristaltic design to deliver volumes from 1 μL to 10 mL with a higher degree of flexibility than what current technology allows. Three autoclaveable cassettes (1, 5, and 10 μL) each incorporate the appropriate dimension tubing and configuration to accurately produce full incremental volumes of liquid for the best performance within each specified volume range.
Flexibility is further enhanced through automatic dispense height adjustment, automation capability and uncomplicated software. Users can dispense up to eight distinct reagents at a time, and can also choose to dispense into or skip any microplate row or column. A two-stage priming tray can direct liquid to waste, or to recovery, for precious reagents.
For more information, visit www.biotek.com, or e-mail
BioTool
PetriSphere
According to BioTool, its new PetriSphere system offers a flexible, automated and cost-effective alternative for the generation of atmospheres suitable for culturing anaerobic, microaerophilic, and capnophilic bacteria in commonly used anaerobic jars. The PetriSphere consists of a microprocessor-based controller and a diaphragm vacuum pump. A gas reservoir connection allows the user to replace the air with either nitrogen or carbon dioxide.
The level of oxygen depletion desired, gas exchange pressure, and the number of cycles can be specified by the user and easily programmed in advance using a keypad. The automated process is then started by simply pressing a button. Further time-saving is possible as the system uses quick connect adaptors.
For more information, visit www.biotoolswiss.com, or call +41.34.423.5060.
Cellexus Biosystems
CellMaker PLUS Bioreactor
The CellMaker PLUS is Cellexus Biosystem's new flagship single-use bioreactor CellMaker PLUS for the culture of all cell types. In addition to a wealth of new technologies for the culture of all cell types, it is accompanied by the fusion of single-use technologies that are incorporated into a new disposable bag called the HybridBag. According to Cellexus, this is a world first of its kind and unifies the principles of airlift (as applied in the CellexusBag) with those applied in Stirred Tank Reactors in a single-use culture bag. The CellMaker PLUS bioreactor together with the single-use component the HybridBag, can perform several important operations that significantly improve culture growth compared with shaker-flask systems and other bioreactor designs.
For more information, www.cellexusbiosystems.com.
Technical Note: Evaluation of CellMaker PLUS
A technical note describing the evaluation of the CellMaker PLUS with the use of the HybridBag in a study with CHO-S cells is available from Cellexus Biosystems. In addition, the technical note describes how the system can be readily adapted to suit simple batch or complex fed-batch protocols, and the importance of controlling oxygen in the process, particularly when low concentrations of CHO cells are being cultured.
For more information, visit www.cellexusbiosystems.com/index_files/CellMaker%20PLUS%20technical%20note%20CHO-S.pdf.
ESA Biosciences
Measuring System for Sulfur Compounds
According to ESA Biosciences, it has developed the first stable, sensitive, and robust analytical system that enables routine measurement of thiols, thioethers, disulfides, and other sulfur-containing compounds. The new ESA system incorporates a specially developed electrochemical cell with a unique Boron-Doped Diamond working electrode that provides excellent sensitivity and durability, while eliminating the problems (fouling, high background, mobile phase oxidation) associated with earlier ECD systems.
For more information, visit www.esainc.com, e-mail
Low Reporting Limit for Lactose
According to ESA Bioscience, using its proprietary electrochemical technology, that includes both amperometric and coulometric detectors, reporting limits for lactose (0.5 ng/filter), mannitol (1 ng/filter), naproxen (0.25 ng/filter), and acetaminophen (0.5 ng/filter) are now the lowest available.
For more information, visit www.esainc.com/services/analytical_laboratory_services, e-mail
FEI Company
FEI.com for Owners
A new online service for customers is housed on FEI Company's Web site. In addition to delivering custom content on upgrades and accessories and information on FEI UserClubs and training, the new section features FEI Connect. This networking tool provides owners and users of FEI instruments instant access to a network of peers and FEI applications specialists worldwide.
With membership restricted to only owners and users of FEI tools, FEI Connect operates like a “MySpace” environment where members create unique profiles and enter the community to meet and interact with other members who have similar applications expertise and research or industry interests. The community contains topic-focused user groups on microscopy and nanotechnology, as well as real-time chat, personal and community blogs, and more. Members can share their work with others in their personal profile area. Since its release in mid-August, nearly 200 participants have registered their instrument and created a profile within the community.
For more information, visit http://owners.fei.com.
Titan3 80-300 S/TEM
According to FEI, the Titan3 80-300 system is designed to deliver the highest stability and performance in a commercial scanning/transmission electron microscope (S/TEM). The Titan3 takes the capabilities of FEI's Titan S/TEM microscope, introduced in 2005, to new levels of performance and enhanced operation, giving users the sub-Ångström imaging capabilities of the world's most powerful commercially available microscope (the width of an average strand of human hair ranges from 500,000 to one million Ångströms) and a lower total cost of ownership for a high-end microscope.
The ultra-high resolution S/TEM performance of this new system is achieved by its all-new design that allows—for the first time ever—the combination of two Cs-abberation correctors and a monochromator on a single instrument. The system's innovative enclosure significantly reduces environmental interference, providing greater stability and eliminating the need for many expensive lab improvements.
For more information, visit www.fei.com.
G-Biosciences/Genotech
Fraction-FOCUS
According to G-Biosciences/Genotech, its new Fraction-FOCUS uses proven technology to fractionate and concentrate all proteomes into multiple fractions, simplifying 2D maps and enhancing detection of low abundant proteins. There is no detectable loss of material total protein during the Fraction-FOCUS procedure. At the end of the fractionation, cellular proteins are in one of many fractions. The entire fractionation is carried out in microscale. Fraction-FOCUS is fully compatible with all downstream protein identification techniques.
For more information, visit www.GBiosciences.com.
Genevac
FTS AirJet XE
The FTS AirJet XE is a precision temperature forcing system for temperature testing of electronic components and assemblies. Capable of temperatures from –75 to 225 °C, Genevac says the AirJet XE is the only compact temperature forcing system that exceeds the full Mil-Spec temperature range. Featuring reliable, dual-stage mechanical refrigeration, the AirJet XE delivers unmatched thermal performance and ultra-quiet operation. The AirJet XE offers the convenience of operating on standard 110- or 220-V mains power.
Configurable for benchtop, rack-mounted or mobile applications, the AirJet XE can produce temperature transitions, from +125 to –55 °C in 20 s. An external DUT sensor enables precise temperature control (0.1 °C) and optimized transition rates. Offering facility to create and store up to 48 temperature/ramp/soak test profiles, the AirJet XE can be used by both occasional and specialist users. An Autotuning feature enables the control algorithm to be optimized for DUT mass.
For more information, visit www.genevac.co.uk, e-mail
Virtis AdVantage Plus Freeze Dryers
The new Virtis AdVantage Plus range of freeze dryers from Genevac is available with up to three fluid-cooled shelves that maintain temperature control precision previously available only in pilot/production scale units. With the additional shelf space, a newly designed condenser coil can hold 6 L before defrosting. As with the previous generation AdVantage model, a choice of condenser temperatures at –53, –75, or –85 °C enables processing a wide range of samples in stoppered vials or bulk drying in freeze-dry flasks or trays. An animated synoptic display provides operational status including alarm information at a glance. An optional Wizard workstation enables all aspects of the lyophilization cycle to be precisely controlled, monitored, recorded, and presented in graphic format.
For more information, visit www.genevac.co.uk, e-mail
Guava Technologies
Guava Cell Cycle Assay
This new version of the Guava Cell Cycle Assay is intended to allow quick, easy determinations of G0/G1, S, and G2/M cell cycle phases, and distinguish without interference commonly occurring aggregates. When used in conjunction with a Guava PCA or EasyCyte platform, the enhanced assay offers cell cycle phase analysis at the benchtop without complicated flow cytometric methods. The cell cycle phase percentages and counts are displayed on the same screen as acquisition, without the requirement for involved software setup, making it to visualize the results in both histogram and statistical formats.
Unlike traditional methods, according to Guava, the cell counts for each sample are direct and absolute, without the use of reference beads. This enables the monitoring of whether changes in cell cycle are a result of treatments and not just changes in cell number due to cell proliferation or cell death. The Guava Cell Cycle Assay is a single, optimized reagent that does not require sample preparation and includes detailed protocols for adherent and suspension cells in both 96-well plates and tubes.
For more information, visit www.guavatechnologies.com/main/library/index.cfm.
Hudson Control Group
AutoReactT Mini-Bioreactor System
The new AutoReactT is a mini-bioreactor system for high-throughput cell culturing and fermentation testing. Using a 24-chamber bioreactor vessel with the footprint of a standard microplate, the system automatically loads, samples, and feeds cells growing under 24 independent reaction conditions simultaneously. The entire system fits easily within a standard biosafety cabinet.
The fully automated run frees users from manual sampling or monitoring any of its 24 reactions, even for runs lasting days. Users can input an unlimited number of test conditions to trigger automated feeding and/or sampling of the chambers’ contents, while maintaining the sampled amounts in a chilled environment for the entire length of the run.
For more information, visit www.hudsoncontrol.com.
Hudson SOLO
The Hudson SOLO is a low-cost, high-throughput, single-channel robot pipettor able to perform DNA transformations, cherry-picking, and other applications involving the accurate dispensing of liquids.
According to Hudson, the SOLO's compact 14″ × 16″ (355 mm × 400 mm) footprint can easily fit on lab benchtops and into standard fume hoods. Compatible with 96-, 384-, and 1536-well plate formats, it also has the ability for noncontact dispensing into microplates and slides. It also has a very broad dynamic range and the ability to handle reactions in a sterile environment.
The SOLO can be loaded and operated manually, but is also fully compatible with robot-loading systems from most manufacturers, including Hudson Control's own PlateCrane EX. It can also be used in line with the Hudson Control LabLinx high-throughput track system.
For more information, visit http://www.hudsoncontrol.com.
IDBS
E-WorkBook Suite 7.1
Comprising E-WorkBook, BioBook, and ChemBook, E-WorkBook Suite is designed to allow greater productivity for research scientists by automating data capture and storage. E-WorkBook Suite supports the capture of corporate data, information, and knowledge in one secure infrastructure, promoting regulatory compliance and increasing organizational efficiency.
E-WorkBook Suite 7.1 offers greater search flexibility and enhanced graphing and charting within the BioBook module. Furthermore, additional integration points and Web services included in version 7.1 allow organizations to automate the exchange of any data both to and from other systems. In addition, E-WorkBook Suite 7.1 now allows digital signatures to be applied to PDFs and provides associated taskflow support for this process, thereby extending its industry-standard IP protection.
For more information, visit www.idbs.com.
Invetech
Drug Discovery Market Services
Invetech now offers services to the drug discovery market. The company offers expertise in liquid handling, plate handling, robotics, software interfaces, optics, specialized detection systems, miniaturization, and integration. Identifying the best commercial direction for clients is Invetech's principal goal. According to Invetech, it takes a holistic approach from concept to market, working collaboratively with clients to deliver an integrated range of instrument development, custom automation, and systems integration services. Engineering is coupled with in-house application science to enable field representative product testing during the development process. In-house biosafe laboratories are available for testing of early prototypes with real samples in a representative environment, and for subsequently supporting replicated systems at client sites globally.
For more information, visit www.invetech.us.
MagStar Technologies
Q-Stack Quickdraw Conveyor System
MagStar's line of Quickdraw material-handling automation systems now include the Q-Stack, a modular plate automation conveyor specially designed for handling microplates, tip boxes, and deep-well carriers in a broad range of laboratory-based automation applications. The fast, reliable Q-Stack delivers a flexible conveyed product solution with bidirectional operation, removable stack towers with 400 mm of microplate storage in each, and sensors to detect when stacks are full and/or empty. In addition, the Q-Stack easily integrates into existing Microplate processing lines, and it interfaces with serial communication or discrete I/O, allowing users to monitor collected data from a remote location.
For more information, visit visit www.magstar.com, e-mail
XR Series Quickdraw Conveyor System
The new XR Series Conveyor is another new addition to MagStar's Quickdraw Conveyor Systems. The XR offers the same operation of the MR and HD (Heavy Duty) Series conveyor systems, and features a unique load-carrying ability of up to 120 lbs.
The XR Series bridges the capacity gap between the Quickdraw MR Series (capable of conveying up to 20 lbs of product) and the HD Series (capable of conveying loads of up to 200 lbs), and it is easily configured and integrated into existing production lines. The XR features bidirectional operation with an open center, slip-roller design for accumulation and precise product movement, low-profile design, and connects to auxiliary devices.
For more information, visit www.magstar.com, e-mail
Micronic
TraXis TRxD-Coded Tube Reader
Developed for absolute sample security and traceability, the TraXis TRxD is the only tube reader that can simultaneously read both 2D TraXis codes and 1D linear bar codes. It can read a single code in less than 0.5 s, and comes with an easy-to-use Open Database Connectivity compliant software. The TRxD reader may be simply installed through a USB connection onto any Windows platform where data can be exported to almost any software application. Wireless connectivity is available. An Ethernet socket is provided for simple integration into networks.
For more information, visit www.micronic.com, e-mail
Millipore
Cell Signaling Products and Applications Guide
The new, free guide includes dozens of cell signaling pathways, more than 100 pages of technical articles, an extensive troubleshooting section, as well as thousands of Upstate cell signaling products, including antibodies, enzymes, and kits. The guide covers Millipore's complete range of cell signaling research tools, including kinases, phosphatases, and G-proteins; epigenetics and chromatin function; transcription factors and nuclear receptors; multiplexing and drug discovery services; and pathways, protocols, and troubleshooting tips.
For more information, visit www.millipore.com/guides or call 800.645.5476.
Beadlyte Human Cancer Biomarker Panel
This new panel from Millipore includes a 5-plex containing the biomarkers: macrophage, migration inhibitory factor, prolactin, CA-125, leptin, and osteopontin; and a single-plex IGF-II assay. Each of the biomarkers has been identified in various tumor types including lung, breast, prostate, and colorectal.
The assays can be used to quantify these biomarkers in serum, plasma, and cell/tissue culture supernatant samples. Each panel includes all components to run the assay, standards and quality controls for each plex, and can be easily adapted for high-throughput automation. The panel is considered highly sensitive, offering excellent intra- (<11%) and interassay (<10%) precision.
For more information, visit www.millipore.com.
PANalytical
MiniPal 4 Sulfur
The new MiniPal 4 Sulfur is the latest addition to PANalytical's line of compact, benchtop, energy dispersive X-ray fluorescence spectrometers. The easy-to-use MiniPal 4 Sulfur is designed for the accurate and precise analysis of petrochemicals. The instrument performs nondestructive analysis of elements from sodium to lead, in concentrations from 100% down to ppm levels. MiniPal 4 Sulfur meets the requirements for sulfur analysis according to the international norms ASTM D4294-2007, ASTM D6841, ASTM D6445, ISO 20847, and ISO 8754. The spectrometer can also determine product compliance with other relevant standards, such as German Institute for Standardization (DIN) and U.S. Environmental Protection Agency (EPA).
The MiniPal 4 Sulfur is one of the smallest full-function spectrometers available. It is equipped with a 12-position sample changer; three tube filters, a helium gas attachment for light element analysis, and a 15-kV silver anode tube, the latter selected to give optimum performance for phosphorous, sulfur, and chlorine analysis in petrochemicals. The system also features a new silicon drift detector, improved sensitivity, high maximum count rates, excellent resolution, and lower limits of detection.
For more information, visit www.panalytical.com, e-mail
PerkinElmer
Series 200EP PDA Detector
According to PerkinElmer, its new Series 200EP (Enhanced Performance) Photo Diode Array (PDA) detector expands the capabilities of its Series 200 HPLC offering. The new detector provides deeper insights into results through superior linearity and best-in-class spectral integrity, allowing uncompromised quali-quantitative analysis of complex mixtures. With its wide linear dynamic range and low drift, the Series 200EP PDA detector is considered by PerkinElmer to be the ideal tool for demanding quantitative analyses such as impurities in drug or environmental samples with wide variation in compound concentration.
Coupled with TotalChrom Chromatography Data Systems, the Series 200EP PDA detector is fully network compatible. In addition, IRIS Spectral Processing Software provides intuitive spectral data processing, all protected under a fully 21 CFR Part 11-compliant architecture.
For more information, please visit www.perkinelmer.com/Series200EPPDA.
EcoAnalytix
According to PerkinElmer, its new EcoAnalytix is a problem-solving initiative that addresses the global imperatives of food safety, water quality, and biofuels development by combining high-performance instrumentation with an unprecedented level of technical, application, and regulatory support.
In addition to comprehensive product solutions, each EcoAnalytix platform includes the applications, methodologies, standard operating procedures and training required to complete specific analyses. Plus, thought leadership and public outreach programs bring insights from top scientists and government agencies directly to PerkinElmer customers.
PerkinElmer's latest food safety analyzers include the new Melamine Analyzer, based on the Clarus 600T Gas Chromatograph/Mass Spectrometer; and the new Polycyclic Aromatic Hydrocarbons (PAH) Analyzer, which is based on the Series 200 UV/VIS/Fluorescent HPLC.
The newest EcoAnalytix water quality analyzer is the Trace Metal Analyzer based on the ELAN 9000 ICP-MS and ESI SC-FAST Sample Introduction System for drinking water method 200.8 and other environmental analyses with specific water analysis methods built into the platform.
EcoAnalytix solutions for biodiesel testing, include Biodiesel Gas Chromatography (GC) Turnkey Systems; and LABWORKS Green, a preconfigured lab management and reporting application.
To further support its EcoAnalytix initiative, PerkinElmer has established four global application development centers in Shelton, Connecticut; Seer Green, England; Shanghai, China; and Mumbai, India. Each location serves as a Center of Excellence, focusing on the development of new applications and methods for specific EcoAnalytix platforms.
For more information on the PerkinElmer EcoAnalytix initiative, visit http://www.perkinelmer.com/ecoanalytix.
PAH Analyzer
This new preconfigured system is for the analysis of polycyclic aromatic hydrocarbons (PAH), organic pollutants widely distributed in the environment that can be carcinogenic at certain levels. The PAH Analyzer provides laboratories conducting high-performance liquid chromatography (HPLC) analyses for environmental and food testing with a complete system to expedite ramp-up and increase uptime for challenging PAH sample analyses that require specific regulated methods. The PAH Analyzer will support contract laboratories in the environmental and food safety sectors, along with government and academic laboratories.
For more information, visit www.perkinelmer.com/PAH.
Melamine Analyzer
PerkinElmer now offers a complete analyzer that uses gas chromatography/mass spectrometry (GC/MS) for the determination of melamine adulteration in protein-based foods. PerkinElmer's Melamine Analyzer includes all instrumentation, consumables, and application resources needed to screen for melamine contamination. The method for the Melamine Analyzer was developed in collaboration with Flora Research Laboratories, an U.S. Food and Drug Administration (FDA) and U.S. Drug Enforcement Agency (DEA) registered independent testing laboratory specializing in natural products.
The Melamine Analyzer includes a Clarus 600T GC/MS with autosampler and TurboMass GC/MS software, all consumables needed for analysis, and an application CD for rapid ramp-up. The application CD includes methods and sample data, a library of derivatized compounds spectra of melamine and related compounds, a melamine application guidebook and an application note that describes the analytical method in detail.
For more information, visit www.perkinelmer.com/melamine.
Clarus 400 Gas Chromatograph
The new Clarus 400 GC is designed to meet the needs of industrial and analytical laboratories in price-sensitive environments and academic laboratories globally.
The Clarus 400 GC offers an optional autosampler for increased productivity and has a number of features to support laboratories in global markets including a choice of keypad user interfaces in five languages. It is designed for an easy installation supported by localized documentation. Also, as with all other GCs in the Clarus family, the Clarus 400 GC can be coupled with PerkinElmer's TurboMatrix Headspace Samplers and Thermal Desorbers for added application capabilities.
For more information, visit www.perkinelmer.com/Clarus400GC.
Promega
HaloCHIP System
According to Promega, its new HaloCHIP System is the first antibody-free alternative to chromatin immunoprecipitation (ChIP). ChIP is a method used to determine where, in vivo, a given protein binds to DNA. The major challenge of the ChIP method is the requirement for highly specific antibodies for each protein to be tested. The HaloCHIP System is the first to work without the use of antibodies.
In addition to being antibody-free, Promega says its HaloCHIP delivers results in less time than standard ChIP (2 days vs. 4 days), and improves signal-to-noise ratios, enabling higher sensitivity for detection of even small changes in protein-binding patterns from a reduced number of cells.
The HaloCHIP System is based on HaloTag Technology from Promega. The HaloTag reporter protein has been engineered to form a covalent interaction with a series of specific ligands, including one for immobilization, HaloLink Resin. In HaloCHIP, DNA-binding proteins of interest are expressed in cells as HaloTag fusion proteins, crosslinked to DNA with formaldehyde, and then covalently captured on HaloLink Resin. After the captured complexes are rigorously washed to remove any nonspecific interactions, crosslinks are reversed, and the specific DNA is released for downstream analysis.
For more information, visit www.promega.com.
Radleys
PC VARIO 3001 Chemistry Pumping Unit
The PC VARIO 3001 Chemistry Pumping Unit is a new generation of diaphragm pumping system for small- to medium-scale chemistry applications including evaporation, sample concentration, drying, and distillation. It combines the performance and reliability, even in tough operating conditions, of its predecessor (the PC VARIO 2001) with a new highly intuitive vacuum controller. The new controller provides time-saving through simplified operation resulting from easy-to-use jog wheel operation and clear text menus.
Using proven low vacuum chemistry pumping technology, Radleys says its PC VARIO 3001 sets the standard for reliability, reproducibility, efficiency, and low operational noise in a compact benchtop unit. Providing vacuum down to 2 mbar and a pumping speed of up to 1.7 m3/h, the PC VARIO 3001 delivers fast, continuously high evaporation rates even with high boiling point solvents. High performance combined with fully automatic adaptation of the vacuum to the actual process parameters means that process times with the PC VARIO 3001 are typically 30% shorter and without the need for any user programming.
The PC VARIO 3001 with automatic boiling point detection and antibumping technology as standard means that it is no longer necessary to constantly monitor the process. Low cost of ownership is ensured through use of PC VARIO 3001 “no stress” chemically resistant PTFE and fluorinated plastic head design for all parts coming into contact with the pumped media with service intervals typically exceeding well in excess of 20,000 running hours. For more information, visit www.radleys.co.uk.
Syrris
Orbit Parallel Chemistry Module
The Atlas family of products now includes the Orbit Parallel Chemistry Module. This new parallel reaction station is designed with flexibility in mind and readily fits the Atlas Hotplate, Hot and Cold Circulator Plate, or any regular third party equivalent. Orbit can accommodate different numbers of tubes, and with a wide temperature range, it allows reactions to be heated to 280 °C with reflux or cooled to –40 °C. Reactions are magnetically stirred in an inert atmosphere, and as all operations are tool-free, the Orbit is a safe and easy-to-use synthesis station.
Available in two different sizes, Orbit can accommodate up to 6 × 45 mL tubes or 12 × 10 mL tubes, and incorporates a quick, twist-and-click lid seal which when closed, immediately applies an inert atmosphere to all tubes. When the Orbit lid is removed, the septa are automatically resealed and the tubes are free to be safely transported. The septa covering each vessel are reusable and simply replaced. In addition, Orbit's unique design allows the gas and water supplies to remain connected to the reflux unit and the rack of tubes to be removed independently.
For more information, visit www.syrris.com.
Lara Reactor Control Software
For laboratories looking to perform medicinal and process scale-up, scale-down or optimization experiments, an improved version of Lara reactor control software is now available. The software can be used with the Radleys Lara Controlled Lab Reactor (CLR), and can also function as a standalone package to control/automate other nonautomated reaction systems. The software provides reactor users with a wide range of functionality, including third party equipment control, automated data logging, graphing functions, and postexperimental analysis.
Designed to enable any chemist to use intuitively, the version 2.0 Lara control software offers enhanced flexibility, expanded safety features, and simple operation. To enable on-the-fly control, the new software provides users with direct access to editing parameters including temperature, stirring speed, and pump/additions rate while an experiment/recipe is running. New feedback loops allow users to set limits enabling precise automated control of reactions using data from external sensors attached to the system, such as temperature, pH, and turbidity. Also available are expanded options for third party equipment integration and a suite of new recipe control functions. The new version 2.0 Lara control software is offered as a free upgrade to all existing Radleys Lara CLR users, or can be purchased separately for control of a traditional reactor system.
For more information, visit www.syrris.com.
The Automation Partnership
Capit-All
Capit-All is a new system for automatically removing and replacing screw caps from microtubes. Capit-All can simultaneously unscrew and recap 96 tubes held in standard 96-way tube racks. Each cap is replaced concurrently and individually tightened to an excellent seal, avoiding the risk of putting the wrong lid back on a tube and eliminating a source of cross-contamination.
Capit-All can process common tube types including Nunc's CryoBank and Bank-It cryotubes, Micronic's Tracker and TraXis tubes, and Matrix's TrackMate range. Because the system uses an SBS standard rack format, the rack can be transferred to most commercial liquid handlers, making it easy to add Capit-All into an automation workflow. With a small footprint, Capit-All can fit on any bench or in laboratory or microbiological safety cabinets and is light enough to be portable.
For more information, visit www.automationpartnership.com.
Thermo Fisher Scientific
Online Demo: AA Spectrometers
A new Web tool by Thermo is designed to serve as a fast and convenient evaluation tool for high-throughput elemental analysis laboratories in a variety of application areas including environmental, food and beverage, petrochemical and metallurgy industries.
The demo focuses on six key benefits of the Thermo Scientific S Series Atomic Absorption (AA) spectrometers—performance, ease-of-use, ease-of-learning, application-tailored configuration, regulatory compliance, and small footprint. Real-time video footage demonstrates ease-of-operation of the instruments’ automatic lamp carousel and sample introduction system. In addition, it provides step-by-step navigation of the SOLAAR software wizards. The demo also offers a comprehensive list of the accessories available for use with the S Series AA spectrometers.
For more information, visit www.thermo.com/aa.
Atlas CDS Control Software
The new Atlas Chromatography Data System (CDS) add-on instrument control software for the Thermo Scientific Accela High-Speed LC integrates full instrument control and chromatography data handling for the Accela high-speed pump, autosampler, and PDA detector, and is designed to marry the rapid data analysis, processing, and reporting of Atlas with the High-Speed LC separations of the Accela.
For more information, visit www.thermo.com/lc, e-mail
Nautilus LIMS Version 8.0
Now installed with Data Manager, Thermo Scientific Nautilus can capture, archive, and store both derived and raw instrument data, permitting users instant access and manipulation of the data without the original software.
Data Manager is a complete storage and retrieval system that understands and preserves analytical data, documents, and PDF files. It is able to view, search, and manipulate real data and its metadata without the original application. It is designed to address long-term storage issues by being platform and manufacturer independent.
Thermo Scientific Nautilus 8.0 is designed to give scientists a comprehensive instrument-unified view of all relevant data directly from the LIMS rather than at the lab bench via multiple software packages. Drawing on technology from Thermo Scientific's GRAMS Suite for visualizing, processing, and managing spectroscopy data, the Data Manager module converts instrument data to a vendor-neutral XML format and allows automatic linking to LIMS entities for instant investigation of suspect results.
For more information, visit www.thermo.com/informatics, e-mail marketing.
LIMS
Thermo has Web-enabled its laboratory information management systems (LIMS) with Microsoft's ClickOnce deployment technology to create a solution that combines the functionality and performance of the desktop client delivered via the simplicity of a Web interface.
For more information, visit www.thermo.com/informatics, e-mail
Velocity11
Automated Microplate Spin-Down Station
A new automated microplate spin-down station from Velocity11 enables batches of microplates to be spun down in parallel. Integrating the Velocity11 BenchCel Microplate Handling System and VSpin Access2 Automated Microplate Centrifuge, the new workstation provides walk-away convenience for handling up to 320 microplates. A simple software interface allows users to specify the centrifugation settings.
According to Velocity11, the VSpin-Automated Microplate Centrifuge is the smallest robotic-accessible automated centrifuge on the market. It provides unmatched vibration and noise control in a small, low-maintenance package. Considered ideal for high or medium throughput applications, the VSpin features a dual position design to accommodate two standard microplates at a time. The VSpin is capable of rapid acceleration and deceleration (a customizable setting), minimizing the required cycle time. The VSpin is the perfect tool for filtration protocols, air bubble removal in high-density plates and spin-downs including cells and cellular debris. VSpin units can be stacked to save space. The door design allows access to the bucket by a range of articulated arm robots. For robots that cannot reach through the door, the Access2 plate loader allows unobstructed accessibility. With a 3-s loading time and robust motion control, the VSpin Access2 is the only universally accessible microplate centrifuge.
For more information, visit www.velocity11.com.
Viscotek
Applications Poster: Characterization of Branched Copolymers by Tetra Detection GPC/SEC
Using samples provided by Unilever Research and Strathclyde University, this report discusses characterization of polymers that are complex both in terms of structure and composition, and that present many difficulties for conventional GPC/SEC techniques.
In the report, the analysis of four copolymers samples (one linear and three branched) on a Viscotek Tetra Detector system with OmniSEC software is discussed. Results are presented showing how molecular weight, intrinsic viscosity, and molecular size data are obtained directly and how using the OmniSEC software, the amount of branching is determined in the three samples relative to the linear reference. Ratioing the response from the two concentration detectors (RI and UV), the report also is able to determine chemical composition differences in the branched samples.
For more information, visit www.viscotek.com, e-mail
Zinsser Analytic
Formula X
Formula X is a new combinatorial workbench system to automate the search for new formulations and for the optimization of existing formulations in pharmaceuticals. Formula X is equipped with four standard pipetting probes for liquid handling and a variable volume precision powder-dispensing pipette for the distribution of solid compounds. Highly viscous reagents (2000–10,000 cps) are distributed under active temperature control. Gravimetric distribution of all reagents and samples gives maximum precision.
The entire process, sample storage, liquid handling, stirring, and vortexing of samples are temperature controlled. Capping and decapping, crimping of HPLC vials can be supplied as options.
For more information, visit www.zinsser-analytic.com.
More news
Death Valley was selected as the site for Mission #3 of Mr. Carlos Montero, a certified microbiologist, joined the BioTek Instruments team as a product specialist, and will travel extensively within Latin America to provide technical, educational, and sales support to researchers and BioTek's existing distribution network within the area. Likewise, Mr. John Fiducia was named director of global service operations, responsible for supporting all of BioTek's customers and distribution partners in areas including service, technical support and technical training. BioTek Instruments President and CEO Briar Alpert was elected to the Board of Directors of the According to According to IDBS announced a strategic partnership with Thermo Fisher Scientific's iCAP 6500 emission spectrometer was used by Thermo Fisher Scientific announced an internal process improvement initiative within its global laboratory informatics (LIMS) line of business. According to Thermo, its new CARES Initiative ( The
Call for Papers
Share your work with other lab automation professionals!
JALA publishes six peer-reviewed issues each year, and accepts manuscripts on an ongoing basis from ALA members and nonmembers. Lab automation professionals are invited to showcase their achievements by submitting method-focused scientific papers for publication consideration. Manuscript guidelines and submission information are available at www.labautomation.org/journal/submissions.cfm.