Mild traumatic brain injury (MTBI) is a transient disturbance of neuronal function and may include symptoms ranging from temporary and mild to disabling problems that can affect social relationships, employment, and daily functions. Because symptoms of MTBI vary and are sometimes subtle, persons who sustain the injury do not always report their injury or are not diagnosed. Differing outcomes have been attributed to failure to diagnose MTBI. This article describes the prevalence of MTBI in psychiatric patients; discusses the clinical course following MTBI; and provides guidelines for assessment, diagnosis, and treatment. Lastly, implications for psychiatric nursing are highlighted.