Glucocorticoid receptors were detected in the human inner ear. The highest concentration
of glucocorticoid receptor protein was measured by enzyme-linked immunosorbent assay in
the spiral ligament tissues; the lowest concentration of glucocorticoid receptors was
measured in the macula of the saccule. The demonstration of the presence of glucocorticoid
receptors in human inner ear tissues provides a basis to consider the direct effects of
glucocorticoid action on select inner ear cells, rather than assuming a systemic
antiinflammatory or immunosuppressive effect during the therapeutic treatment of patients
with given inner ear disorders.
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