Sage Journals: Discover world-class research

Abstract

OBJECTIVE: To evaluate the auditory effects of single, double, and triple semicircular canal fenestration procedures, with and without sealing the labyrinthine defect.

BACKGROUND: Violation of the inner ear remains a feared complication in otologic surgery because it commonly leads to profound sensorineural hearing loss. It has been assumed that the natural history of labyrinthine injury in the guinea pig is similar to that in human beings; however, this assumption has not been rigorously studied.

DESIGN: Prospective, randomized, and controlled animal study.

SUBJECTS: Sixty pigmented guinea pigs.

OUTCOME: Click-evoked electrocochleographic response, with same-ear prefenestration control.

RESULTS: All of the fenestration groups had elevated auditory thresholds at 1 hour when compared with controls (P < 0.01); however, this difference lost statistical significance at 1 and 4 weeks. The degree of labyrinthine injury did not correlate with the degree of hearing loss or with the incidence of anacusis. Hearing remained stable during the study period. Sealing the fenestration had no significant audiologic effect (P > 0.40).

CONCLUSIONS: The guinea pig model of labyrinthine fenestration may not be representative of the human condition.

Get full access to this article

View all access options for this article.

References

Carrasco

Pillsbury

. Complications of mastoidectomy. In: Eisele

, editor. Complications in head and neck surgery. St. Louis: Mosby; 1993. p. 650–5.

Sheehy

Brackmann

. Cholesteatoma surgery: Management of the labyrinthine fistula—a report of 97 cases. Laryngoscope 1979;89:78–87.

Gacek

. The surgical management of labyrinthine fistulae in chronic otitis media with cholesteatoma. Ann Otol 1974;(suppl 10):3–19.

Kobayashi

Sakurai

Okitsu

et al. Labyrinthine fistulae caused by cholesteatoma, improved bone conduction by treatment. Am J Otol 1989;10:5–10.

Sanna

Zini

Gamoletti

et al. Closed versus open technique in the management of labyrinthine fistulae. Am J Otol 1988;9:470–5.

Gamoletti

Sanna

Zini

et al. Inner ear cholesteatoma and the preservation of cochlear function. J Laryngol Otol 1990;104:945–8.

Williams

. The technique, end results and present status of the fenestration operation. In: Schuknecht

, editor. Otosclerosis. Henry Ford Hospital International Symposium. Boston: Little, Brown and Company; 1961. p. 221–50.

Antonelli

Kartush

Lundy

et al. Mechanical versus CO₂ laser occlusion of the posterior semicircular canal in humans. Am J Otol 1996;17:416–20.

Parnes

. Treatment of benign paroxysmal positional vertigo by selective ablation of the posterior semicircular canal. Operative Tech Otolaryngol Head Neck Surg 1992;3:48–50.

10.

Parnes

McClure

. Effect on brainstem auditory evoked responses of posterior semicircular canal occlusion in guinea pigs. J Otolaryngol 1985;14:145–50.

11.

Antonelli

Bouchard

Kartush

. CO₂ laser occlusion of the guinea pig posterior semicircular canal. Otolaryngol Head Neck Surg 1995;113:453–8.

12.

Antonelli

Bouchard

Kartush

et al. Triple semicircular canal occlusion in the guinea pig. Otolaryngol Head Neck Surg 1997;117:509–15.

13.

Antonelli

Briggs

Griffin

. Labyrinthine fenestration in acute otitis media. Presented at the Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach (FL); Feb 1996.

14.

Anthony

. Partitioning the labyrinth for benign paroxysmal positional vertigo: Clinical and histologic findings. Am J Otol 1993;14:334–42.

15.

Smouha

Namdar

Michaelides

. Partial labyrinthectomy with hearing preservation: An experimental study in guinea pigs. Otolaryngol Head Neck Surg 1996;114:777–84.

16.

Lee

Wright

Myerhoff

. Modified occipital approach to the endolymphatic sac and cochlear aqueduct of the guinea pig. Am J Otol 1993;14:165–9.

17.

Suitts

Brummett

Nunley

. Effect of otologic drill noise on ABR thresholds in a guinea pig model. Otolaryngol Head Neck Surg 1993;109:660–7.

18.

Shambaugh

Glasscock

. Surgery of the ear. Philadelphia: WB Saunders; 1980. p. 511.

19.

Shambaugh

Takahara

. A clinical and experimental study of the effect of fenestration on the labyrinthine contents. Acta Otolaryngol (Stockh) 1955;(suppl 123):1–32.

20.

Gjuric

Wigand

Hosemann

. Selective resection of the semicircular canals of rabbits with preservation of hearing. Acta Otolaryngol (Stockh) 1992;112:907–15.

21.

Hirsch

Cass

Sekhar

et al. Translabyrinthine approach to skull base tumors with hearing preservation. Am J Otol 1993;14:533–43.

Labyrinthine Fenestration in the Guinea Pig

Abstract

Get full access to this article

References