The authors have investigated the immunological rejection responses against allogeneic tendon tissue using two strains of inbred rats.
A complement dependent cytotoxicity test and an absorbing test were used. The results indicate that the rat tendon tissue contained major histo-compatibility antigens, that this was largely present in tendon cell components, and that collagen showed little or no response.
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References
1.
BECKERU., TIMPLR., and KUHNK. (1972) Carboxyterminal Antigenic Determinants of Collagen from Calf Skin: Localization within Discrete Regions of the Nonhelical Sequence.European Journal of Biochemistry, 28: 221–231.
2.
BENJAMINIE., FONGS., ERICKSONC., LEUNGC. Y., RENNICKD., and SCIBIENSKIR. J. (1977) Immunity to Lymphoid Tumors Induced in Syngeneic Mice by Immunization with Mitomycin C-Treated Cells.The Journal of Immunology, 118: 685–693.
3.
GORERP. A., and O'GORMANP. (1956) The Cytotoxic Activity of Isoantibodies in Mice.Transplantation Bulletin, 3: 142–143.
4.
GOTOHDAE., MORIUCHIT., KODAMAT., and KOBAYASHIH. (1979) Stabilized expression of tumor-associated antigens in xenogenized tumor cells to complement-dependent cytotoxicity.GANN Monograph on Cancer Research, 23: 47–56.
5.
GRAHAMW. C., SMITHD. A., and McGUIREM. P.(1955) The Use of Frozen Stored Tendons for Grafting.The Journal of Bone and Joint Surgery, 37A: 624.
6.
GRAUH. R. (1958) The Artificial Tendon: An Experimental Study.Plastic and Reconstructive Surgery, 22: 562–566.
7.
ISELINF. (1975) Preliminary observations on the use of chemically stored tendinous allografts in hand surgery. In Symposium on Tendon Surgery in the Hand.St. Louis.The C. V. Mosby Company: 66–69.
8.
KATAOKAT., OH-HASHIF., TSUKAGOSHIS., and SAKURAIY. (1977) Induction of Resistance to L1210 leukemia in BALB/c x DBA/2Cr F1 Mice, with L1210 Cells Treated with Glutaraldehyde and Concanavalin A.Cancer Research, 37: 964–968.
9.
MINAMIA., MIZUSHIMAY., TAKEICHIN., HOSOKAWAM., and KOBAYASHIH. (1979) Dissociation of Anti-Tumor Immune Responses in Rats Immunized with Solubilized Tumor-Associated Antigens from a Methylcholanthrene-Induced Fibrosarcoma.International Journal of Cancer, 23: 358–365.
10.
MINAMIA., KASAIM., MIZUSHIMAY., TAKEICHIN., HOSOKAWAM., and KOBAYASHIH. (1980) Characterization of Immunosuppressor Cells in Rats Immunized with Solubilized Tumor-associated Antigens Prepared from a Methylcholanthrene-induced Fibrosarcoma.Cancer Research, 40: 2129–2134.
11.
OIKAWAT., GOTOHDAE., AUSTINF. C., TAKEICHIN., and BOONEC. W. (1979) Temperature-dependent Alteration in Immunogenicity of Tumor-associated Transplantation Antigen Monitored via Paraformaldehyde Fixation.Cancer Research, 39: 3519–3523.
12.
PEACOCKE. E.Jr. (1959) Morphology of Homologous and Heterologous Tendon Grafts, Surgery, Gynecology and Obstetrics, 109: 735–742.
13.
PEACOCKE. E.Jr. (1960) Homologous Composite Tissue Grafts of The Digital Flexor Mechanism in Human Beings.Plastic and Reconstructive Surgery, 25: 418–421.
14.
STEFFENC., TIMPLR., and WOLFFI. (1964) Immunogenicity and Specificity of Collagen. II. Investigations about Specificity of Collagen and its Derivatives by Hemagglutination and Hemagglutination-Inhibition of Anti-Collagen and Anti-Parent Gelatine Immune Sera.Journal of Immunology, 93: 656–667.
15.
STEFFENC., TIMPLR., and WOLFFI. (1968) Immunogenicity and Specificity of Collagen. Demonstration of Three Different Antigenic Determinants on Calf Collagen.Immunology, 15: 135–144.
16.
TAKAHASHIT. (1955) Experimental studies on core materials for artificial tendons and ligaments, especially on the superiority of Amilan (Nylon) cores.Journal of the Japanese Orthopedic Association, 29: 535–558.
17.
TAKEICHIN., ECONOMOUG. C., and BOONEC. W. (1976) Accelerated Regeneration of Trypsintreated Surface Antigens of Simian Virus 40-transformed BALB/3T3 Cells Induced by X-irradiation.Cancer Research, 36: 1258–1262.