The relative proportion of collagen type I and type III in the aponeurosis of twenty-four patients with Dupuytren's disease was determined and compared with the aponeurosis of normal persons. The presence of considerable amounts of type III collagen was found in the Dupuytren's disease patients. The sera of the patients were screened for circulating anti-collagen antibodies using a sensitive radioimmunoassay. In seven out of the twenty-four patients low concentrations of these antibodies were found.
Get full access to this article
View all access options for this article.
References
1.
BAILEYA. J., BAZINS., SIMST. J., LeLOUSM., NICOLETISC., and DELAUNAYA (1975). Characterisation Of The Collagen Of Human Hypertrophic And Normal Scars.Biochimica et Biophysica Acta405: 412–421.
2.
BAILEYA. J., SIMST. J., GABBIANIG., BAZINS., and LeLOUSM. (1977). Collagen of Dupuytren's Disease.Clinical Science and Molecular Medicine53: 499–502.
3.
BAZINS., LeLOUSM., DELAUNAYA., BZOWSKIA., BAILEYA., d'ANDIRANG., and GABBIANIG. (1977). Le collagéne des aponévroses palmaires chez les sujets atteints de maladie de Dupuytren.Comptes Rcnuus Hebaomaires Des Séances De L'Académie Des Sciences, Paris285: 439–442.
4.
CALNANJ. (1977) Keloid and Dupuytren's contracture.Annals of Rheumatic Diseases36 (Suppl. 2): 18–22.
5.
CHUNGE., and MILLERE. J. (1974). Collagen Polymorphism: Characterization of Molecules with the Chain Composition (∝1(III)3 in Human Tissues.Science183: 1200–1201.
6.
DUPUYTRENG. (1831). De la rétraction des doigts par suite d'une affection de l'aponévrose palmaire.Journal de l'Université, Médecine et Chirurgie, Paris, 5: 352–355.
7.
EPSTEINE. H. J. (1974). (∝1(III)3 Human Skin Collagen. Release by pepsin digestion and preponderance in fetal life.The Journal of Biological Chemistry249: 3225–3231.
8.
GayS., and GayB. (1972). Ist die Dupuytrensche Kontraktur eine Autoimmunerkrankung?Zenlralblatt für Chirurgie97: 728–733.
9.
HUESTONJ. T., and TUBIANAR., Editors, Dupuytren's Disease.Edinburgh and London, Churchill Livingstone (1974).
10.
HUNTERJ. A. A., OGDONC., and NORRISM. G. (1975). Dupuytren's Contracture I. Chemical Pathology.British Journal of Plastic Surgery28: 10–18.
11.
LUDWIGH., and KNAPPW. (1974). Immunfluoreszenzdiagnose innerer Erkrankungen.Wiener klinische Wochenschrift86: 709–716.
12.
MENZELJ. (1977). Radioimmunoassay for anticollagen-antibodies using 14C-Labelled Collagen.Journal of Immunological Methods15: 77–95.
13.
MENZELJ., STEFFENC., KOLARZG., KOJERM., and SMOLENJ. (1978). Demonstration Of Anticollagen Antibodies In Rheumatoid Arthritis Synovial Fluids By 14C-Radioimmunoassay.Arthritis and Rheumatism21: 243–248.
14.
MILLESIH. (1959). Neue Gesichtspunkte in der Pathogenese der Dupuytrenschen Kontraktur.Bruns’ Beiträge zur klinischen Chirurgie198: 1–25.
15.
MILLESIH. (1965). Zur Pathogenese und Therapie de Dupuytrenschen Kontraktur. Eine Studie an Hand von mehr als 500 Fällen).Ergebnisse der Chirurgie und Orthopädie47: 51–101.
16.
NOEVAK., KARAGANTCHEVAS., and TOSHKOVA. S. (1977). Antigamma Globulin Factors And Levels Of IgG, IgA and IgM In Sera Of Patients With Dupuytren's Contracture.Acta Chirurgiae Plasticae19: 56–62.
17.
STEFFENC. (1970). Consideration of pathogenesis of rheumatoid arthritis as collagen autoimmunity.Zeitschrift fur Immunitätsforschung Allergie und Klinische Immunologie139: 219–227.
18.
STEFFENC., LUDWIGH., THUMBN., FRANKO., EBERLR., and TAUSCHF. (1973). Nachweis von Antikörpern mit verschiedener Kollagenspezifität bei progressiv chronischer Polyarthritis und Vergleich von Humankollagen und Kalbskollagen als Testantigen.Klinische Wochenschrift, 51: 222–229.
19.
STEGEMANNH., and STALDERK. (1967). Determination Of Hydroxyproline.Clinica Chimica Acta18: 267–273.
20.
STEVENF. S., and JACKSOND. S. (1967). Purification and Amino Acid Composition of Monomeric and Polymeric Collagens.Biochemical Journal104: 534–536.
