Clinical as well as radiologic diagnosis of infantile fibrosarcoma (IFS) is often a challenging problem due to similarities with tumors of vascular origin. Consequently, in the majority of cases, histological and immunohistochemical studies are considered gold standards for the final diagnosis. The two case reports and the review of literature discussed should increase the important features in the history and the presentation that increase the index of suspicion for IFS, as well as it highlights the important characteristics of imaging and laboratory studies that confirm its diagnosis.
AkyuzC.SariN.VargelI.A newborn with infantile fibrosarcoma of foot: treatment with chemotherapy and extremity-sparing surgery. J Perinatal.2010;30:63–5.
2.
BoonL.M.FishmanS.J.LundD.P.Congenital fibrosarcoma masquerading as congenital hemangioma: report of two cases. J Pediatr Surg.1995;30:1378–81.
3.
CanaleS.VanelD.CouanetD.Infantile fibrosarcoma: magnetic resonance imaging findings in six cases. Eur J Radiol.2009;72:30–7.
4.
CelkanT.ÖzkanA.ApakH.Two different clinical presentations of infantile fibrosarcoma. Turkish Journal of Cancer.2000;30:81–6.
5.
CoffinC.M.FletcherJ.A.Infantile fibrosarcoma. In: FletcherC.D.M.UnniK.K.MertensF., editors. World health organization classification of tumours. Pathology and genetics of the tumours of soft tissues and bones. Lyon: IARC Press; 2002. p. 98–100.
6.
DubusP.CoindreJ.M.GroppiA.The detection of Tel-TrkC chimeric transcripts is more specific than TrkC immunoreactivity for the diagnosis of congenital fibrosarcoma. J Pathol.2001;193:88–94.
7.
GulhanB.KupeliS.YalcnB.An unusual presentation of infantile fibrosarcoma in a male newborn. Am J Perinatol.2009;26:331–3.
8.
KagawaK.ParkS.TaniguchiK.Infantile fibrosarcoma: report of two cases. Scand J Plast Reconstr Surg Hand Surg.1999;33:105–9.
9.
KonezO.BurrowsP.E.MullikenJ.B.Angiographic features of rapidly involuting congenital hemangioma (RICH). Pediatr Radiol.2003;33:15–9.
10.
KurkchubascheA.G.HalvorsonE.G.FormanE.N.The role of preoperative chemotherapy in the treatment of infantile fibrosarcoma. J Pediatr Surg.2000;35:880–3.
11.
LiuQ.SchwallerJ.KutokJ.Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12,15)(p13, q25) in congenital fibrosarcoma and 239 acute myelogenous leukemia. EMBO J.2000;19:1827–38.
12.
LohM.L.AhnP.Perez-AtaydeA.R.Treatment of infantile fibrosarcoma with chemotherapy and surgery: results from the Dana-Farber Cancer Institute and Children's Hospital, Boston. J Pediatr Hematol Oncol.2002;24:722–6.
MuzaffarA.R.FriedrichJ.B.LuK.K.Infantile fibrosarcoma of the hand associated with coagulopathy. Plast Reconstr Surg.2006;117:81e–6.
15.
NiekerkM.L.NelW.A.SlavikT.Infantile fibrosarcoma of the ileum presenting with congenital bowel obstruction. J Pediatr Surg.2010;45:461–4.
16.
OrbachD.ReyA.CecchettoG.Infantile fibrosarcoma: management based on the European experience. J Clin Oncol.2010;28:318–23.
17.
PoustiT.J.UptonJ.LohM.Congenital fibrosarcoma of the upper extremity. Plast Reconstr Surg.1998;102(4):1158–62.
18.
RaoS.I.UppinS.G.RatnakarK.S.Infantile *rhabdomyofibrosarcoma: a distinct variant or a missing link between fibrosarcoma and rhabdomyosarcoma?Indian J Cancer.2006;43:39–42.