Nervous lipofibromatous hamartoma is a rare tumor-like condition involving the peripheral nerves, whereby the epineurium and perineurium are enlarged and distorted by excess of fatty and fibrous tissues that infiltrate between and around nerve boundaries. The median nerve is much more likely to develop a hamartoma than other nerves with a predilection for the carpal tunnel. We present a case of carpal tunnel syndrome in an adult caused by fibrolipomatous hamartoma of the median nerve, successfully removed by excision of the fibrolipomatous tissue and decompression.
AmadioPCReimanHMDobynsJH. Lipofibromatous hamartoma of nerve. J Hand Surg [Am].1988;13:67–75.
2.
AmadioPCReimanHMDobynsJH. Lipofibromatous hamartoma of nerve. J Hand Surg.1988;13A:67–75.
3.
BorenWLHenryREJrWintchK. MR diagnosis of fibrolipomatous hamartoma of nerve: association with nerve territoryoriented macrodactyly (macrodystrophia lipomatosa). Skeletal Radiol.1995;24:296–7.
4.
CavallaroMCTaylorJAGormanJD. Imaging findings in a patient with fibrohpomatous hamartoma of the median nerve. Am J Roentgenol.1993;161:837–8.
5.
CavallaroMCTaylorJAGormanJD. Imaging findings in a patient with fibrolipomatous hamartoma of the median nerve. AJR Am J Roentgenol.1993;161:837–8.
6.
De MaeseneerMJaovisidhaSLenchikL. Fibrolipomatous hamartoma: MR imaging findings. Skeletal Radiol.1997;26:155–60.
7.
EnzingerFWWeiseSW. Soft tissue tumours. St Louis: Mosby; 1988 p. 332–4.
8.
EvansHADonnellyLFJohnsonND. Fibrolipoma of the median nerve: MRI. Clin Radiol.1997;52:304–7.
9.
FletcherCDMUnniKMertensK, editors. WHO classification of tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC; 2002 p. 24–5.
10.
FrykmanGKWoodVE. Peripheral nerve hamartoma with macrodactyly in the hand: report of three cases and review of the literature. J Hand Surg [Am].1978;3:307–12.
11.
HerrickRTGodsilRDJrWidenerJH. Lipofibromatous hamartoma of the radial nerve: a case report. J Hand Surg [Am].1980;5:211–3.
12.
LangaVPosnerMASteinerGE. Lipofibroma of the median nerve: a report of two cases. J Hand Surg [Br].1987;12:221–3.
13.
LangaVPossnerMAStrinerGE. Lipofibroma of the median nerve: a report of two cases. J Hand Surg.1987;12B:221–3.
14.
LouisDSHankinFMGreeneTL. Lipofibromas of the median nerve: long-term follow up of four cases. Am J Hand Surg.1985;10a(3):403–7.
15.
LouisDSHankinFMGreeneTL. Lipofibromas of the median nerve: long-term follow-up of four cases. J Hand Surg.1985;10A:403–8.
16.
LyJQBui-MansfieldLTSanDiegoJWBeamanNAFickeJR. Neural fibrolipoma of the foot. J Comput Assist Tomogr.2003;27:639–40.
17.
MaromEMHelmsCA. Fibrolipomatous hamartoma: pathognomonic on MR imaging. Skeletal Radiol.1999;28:260–4.
18.
MeyerBURorichtS. Fibrolipomatous hamartoma of the proximal ulnar nerve associated with macrodactyly and macrodystrophia lipomatosa as an unusual cause of cubital tunnel syndrome. J Neurol Neurosurg Psychiat.1997;63(6):808–10.
19.
MorleyGH. Intraneural lipoma of the median nerve in the carpal tunnel. Report of a case. J Bone Joint Surg Br.1964;46:734–5.
20.
NogueiraAPenaCMartinezMJ. Hyperostotic macrodactyly and lipofibromatous hamartoma of the median nerve associated with carpal tunnel syndrome [review]. Chir Main.1999;18:261–71.
21.
RanawatCSAroraMMSinghRG. Macrodystrophia lipomatosa with carpal-tunnel syndrome. A case report. Am J Bone Joint Surg Sep.1968;50(6):1242–4.
22.
SilvermanTAEnzingerFM. Fibrolipomatous hamartoma of nerve. A clinicopathologic analysis of 26 cases. Am J Surg Pathol.1985;9:7–14.
23.
Van BreuseghemISciotRPansSGeusensEBrysPDe WeverI. Fibrolipomatous hamartoma in the foot: atypical MR imaging findings. Skeletal Radiol.2003;32:651–5.
24.
WongBZAmramiKKWengerDE. Lipomatosis of the sciaticnerve: typical and atypical MRI features. Skeletal Radiol.2006;35:180–4 [Epub 2005 Nov 8].
